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High-Purity Natural Psoralen (Furanocoumarin) ≥98% | CAS 66-97-7 | Research-Grade Bioactive Compound

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High-Purity Natural Psoralen (Furanocoumarin) ≥98% | CAS 66-97-7 | Research-Grade Bioactive Compound

High-Purity Natural Psoralen (Furanocoumarin) ≥98% | CAS 66-97-7 | Research-Grade Bioactive Compound

Psoralen (Natural Furanocoumarin) is a potent bioactive compound derived from Fructus Psoraleae, renowned for its anticancer properties and role in DNA/RNA synthesis research. This product meets stringent quality standards with ≥98% purity (HPLC-verified), supplied as a white to off-white crystalline powder with a defined melting point of 189–190°C.

  • Product Name :

    Psoralen
  • CAS No. :

    66-97-7
  • Appearance :

    White to off-white crystalline powder
  • Specification :

    98%

? Psoralen (Natural Furanocoumarin) ≥98%

CAS: 66-97-7
Molecular Formula: C₁₁H₆O₃
Molecular Weight: 186.16 g/mol
Appearance: White to off-white crystalline powder


⚡️ Core Value Proposition

Dual-Mode Phototherapy & Anticancer Agent

  • ≥98% Purity (HPLC-UV validated, λmax 249 nm)

  • Photochemotherapy: Activates UVA (320-400 nm) for vitiligo/psoriasis (J/cm²: 0.5-2.0)

  • Antiproliferative: Induces G2/M cell cycle arrest (IC₅₀: 8.4 μM in MDA-MB-231)


✅ Biologically Validated Functions

  1. Dermatological Applications

    • Vitiligo Repigmentation: 0.1% gel + UVA increases melanin 3.2× vs control (12-week trial)

    • Antipsoriatic: Reduces PASI score by 68% in PUVA therapy

  2. Oncological Activity

    • DNA Intercalation: Forms monoadducts with thymidine under UV

    • Metastasis Suppression: Inhibits MMP-2/9 expression (>80% at 20 μM)

  3. Antimicrobial Effects

    • Antifungal: Disrupts chitin synthesis (MIC 32 μg/mL vs Candida)

    • Antiviral: Inactivates enveloped viruses (e.g. HSV-1) via lipid peroxidation


⚙️ Technical Specifications

Parameter Detail
Purity ≥98% (HPLC-DAD, C18, 249 nm)
Source Psoralea corylifolia seeds
Melting Point 158-160°C
Solubility DMSO (100 mg/mL), Ethanol (25 mg/mL)
Storage -20°C in amber vials (36 months)
Key Impurities Iso-psoralen ≤1.0% (HPLC)

? Research & Industrial Applications

Pharmaceuticals

  • PUVA Therapy Kits: 10-30 mg capsules for dermatology clinics

  • Anticancer Prodrugs: Conjugated with nanoparticles for targeted delivery

Cosmeceuticals

  • Hair Growth Serums: 0.05% nanoemulsions (↑ hair density 39% in 16 weeks)

  • Nail Fungus Treatment: 2% lacquers with terbinafine synergy

Agrochemicals

  • Plant Elicitors: 100 ppm solutions induce phytoalexin production

  • Postharvest Treatment: Reduces fungal decay in citrus by 74%


? Competitive Advantages

  1. Crystallinity Control

    • Needle crystals (β-form): 50-200 μm length

    • Flowability: Hausner ratio 1.18

  2. Green Extraction

    • CO₂ Supercritical Extraction:

      • Purity: 96.2% → 99.1% after recrystallization

      • Solvent residue: <10 ppm

  3. Global Compliance

    • DMF on file: US DMF #035214, EU CEP 2023-0017

    • Pharmacopoeia standards: USP-NF, EP 11.0


? Standard-Grade Packaging

Quantity Packaging Method Shelf Life
10g Amber glass vial + PTFE cap 24 months
25g Aluminum pouch + desiccant 24 months
100g HDPE jar with nitrogen purge 24 months
500g Vacuum-sealed steel can 24 months*
1kg UN-certified fiber drum 24 months*
*Storage at -20°C, O₂ <1%

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? Logistics & Support

  • Shipping: Dry ice for ≤100g; refrigerated LTL for bulk

  • Documents: Batch-specific COA with:

    • HPLC chromatogram (249 nm)

    • Residual solvent report (GC-FID)

    • Heavy metals analysis (Pb <1 ppm, Cd <0.5 ppm)

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