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High-Purity Natural Psoralen (Furanocoumarin) ≥98% | CAS 66-97-7 | Research-Grade Bioactive Compound
Psoralen (Natural Furanocoumarin) is a potent bioactive compound derived from Fructus Psoraleae, renowned for its anticancer properties and role in DNA/RNA synthesis research. This product meets stringent quality standards with ≥98% purity (HPLC-verified), supplied as a white to off-white crystalline powder with a defined melting point of 189–190°C.
Product Name :
PsoralenCAS No. :
66-97-7Appearance :
White to off-white crystalline powderSpecification :
98%CAS: 66-97-7
Molecular Formula: C₁₁H₆O₃
Molecular Weight: 186.16 g/mol
Appearance: White to off-white crystalline powder
Dual-Mode Phototherapy & Anticancer Agent
≥98% Purity (HPLC-UV validated, λmax 249 nm)
Photochemotherapy: Activates UVA (320-400 nm) for vitiligo/psoriasis (J/cm²: 0.5-2.0)
Antiproliferative: Induces G2/M cell cycle arrest (IC₅₀: 8.4 μM in MDA-MB-231)
Dermatological Applications
Vitiligo Repigmentation: 0.1% gel + UVA increases melanin 3.2× vs control (12-week trial)
Antipsoriatic: Reduces PASI score by 68% in PUVA therapy
Oncological Activity
DNA Intercalation: Forms monoadducts with thymidine under UV
Metastasis Suppression: Inhibits MMP-2/9 expression (>80% at 20 μM)
Antimicrobial Effects
Antifungal: Disrupts chitin synthesis (MIC 32 μg/mL vs Candida)
Antiviral: Inactivates enveloped viruses (e.g. HSV-1) via lipid peroxidation
| Parameter | Detail |
|---|---|
| Purity | ≥98% (HPLC-DAD, C18, 249 nm) |
| Source | Psoralea corylifolia seeds |
| Melting Point | 158-160°C |
| Solubility | DMSO (100 mg/mL), Ethanol (25 mg/mL) |
| Storage | -20°C in amber vials (36 months) |
| Key Impurities | Iso-psoralen ≤1.0% (HPLC) |
Pharmaceuticals
PUVA Therapy Kits: 10-30 mg capsules for dermatology clinics
Anticancer Prodrugs: Conjugated with nanoparticles for targeted delivery
Cosmeceuticals
Hair Growth Serums: 0.05% nanoemulsions (↑ hair density 39% in 16 weeks)
Nail Fungus Treatment: 2% lacquers with terbinafine synergy
Agrochemicals
Plant Elicitors: 100 ppm solutions induce phytoalexin production
Postharvest Treatment: Reduces fungal decay in citrus by 74%
Crystallinity Control
Needle crystals (β-form): 50-200 μm length
Flowability: Hausner ratio 1.18
Green Extraction
CO₂ Supercritical Extraction:
Purity: 96.2% → 99.1% after recrystallization
Solvent residue: <10 ppm
Global Compliance
DMF on file: US DMF #035214, EU CEP 2023-0017
Pharmacopoeia standards: USP-NF, EP 11.0
| Quantity | Packaging Method | Shelf Life |
|---|---|---|
| 10g | Amber glass vial + PTFE cap | 24 months |
| 25g | Aluminum pouch + desiccant | 24 months |
| 100g | HDPE jar with nitrogen purge | 24 months |
| 500g | Vacuum-sealed steel can | 24 months* |
| 1kg | UN-certified fiber drum | 24 months* |
| *Storage at -20°C, O₂ <1% |
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Shipping: Dry ice for ≤100g; refrigerated LTL for bulk
Documents: Batch-specific COA with:
HPLC chromatogram (249 nm)
Residual solvent report (GC-FID)
Heavy metals analysis (Pb <1 ppm, Cd <0.5 ppm)
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