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Astragalus Extract Cycloastragenol: A Growing Botanical Active for Healthy-Aging and Longevity Research Quick Answer Cycloastragenol is a naturally occurring triterpenoid sapogenin associated with Astragalus species, particularly Astragalus membranaceus. It is closely related to astragaloside compounds and has attracted scientific interest because of its reported effects on telomerase activity and cellular aging-related pathways.  In the United States, Cycloastragenol occupies an interesting position between botanical research, nutraceutical ingredients, healthy-aging products and longevity-focused formulations. The U.S. market already shows commercial and research activity around Cycloastragenol. Major scientific suppliers including Sigma-Aldrich, TCI America, Cayman Chemical and distributors such as VWR list Cycloastragenol for research and natural-product applications. Consumer-facing U.S. products also market Cycloastragenol as a longevity- and telomere-oriented ingredient. For B2B buyers, however, the most important question is not simply whether a supplier offers “Cycloastragenol 98%.” Buyers should evaluate chemical identity, purity, analytical method, botanical source, batch consistency, COA documentation, heavy metals, residual solvents, microbiological specifications and regulatory positioning. For manufacturers and ingredient distributors looking to enter the U.S. healthy-aging market, high-purity Cycloastragenol derived from Astragalus is a specialized botanical ingredient with applications spanning research, nutraceutical development and longevity-oriented product concepts.     Key Takeaways · Cycloastragenol is a triterpenoid sapogenin associated with Astragalus. · It is particularly associated with Astragalus membranaceus research. · Cycloastragenol is structurally related to Astragalus saponins, including astragaloside compounds. · Telomerase activation is one of the most important research areas surrounding Cycloastragenol. · Preclinical studies have investigated Cycloastragenol in cellular aging, oxidative stress, immune-cell function and other biological pathways. · U.S. scientific suppliers already offer Cycloastragenol, including ≥98% HPLC products. · U.S. consumer products also demonstrate commercial interest in Cycloastragenol as a healthy-aging ingredient. · FDA records show that a concentrated Astragalus extract containing >95% Cycloastragenol was the subject of a U.S. New Dietary Ingredient notification in 2010. This does not mean that FDA approved Cycloastragenol as a drug or dietary ingredient; NDI notifications have specific regulatory meanings. · Product identity should be verified carefully because different databases and suppliers may associate Cycloastragenol with different CAS numbers. · For B2B buyers, purity + analytical documentation + batch consistency are more meaningful than a simple “98%” marketing statement.     1. What Is Cycloastragenol? Cycloastragenol is a naturally occurring pentacyclic triterpenoid and sapogenin associated with the roots of Astragalus species. It is particularly relevant to research involving Astragalus membranaceus, a botanical traditionally used in Asian herbal medicine. Chemically, Cycloastragenol is closely associated with Astragalus triterpene saponins. PubChem describes it as an aglycone derivative of astragaloside IV and identifies it as a pentacyclic triterpenoid sapogenin. Typical chemical information includes: Property Cycloastragenol Common Name Cycloastragenol Botanical Source Astragalus species Key Source Astragalus membranaceus Chemical Class Pentacyclic triterpenoid Category Sapogenin Molecular Formula C₃₀H₅₀O₅ Molecular Weight 490.72 g/mol Physical Form Powder Common Research Purity ≥98% HPLC Commercial research suppliers in the U.S. market list Cycloastragenol at ≥98% HPLC, demonstrating that high-purity material is already established within the research-chemical supply chain.     2. Cycloastragenol and Astragalus Extract: What Is the Difference? This distinction is particularly important for B2B buyers. Astragalus Extract is a botanical extract containing multiple naturally occurring constituents. Cycloastragenol is a specific purified triterpenoid constituent associated with Astragalus. Therefore, the terms should not be used interchangeably. Astragalus Extract A standardized Astragalus extract may contain: · Astragalosides · Polysaccharides · Flavonoids · Saponins · Other botanical constituents Cycloastragenol Cycloastragenol represents a more specifically defined chemical constituent. This makes it more appropriate when a formulation or research project requires: · defined chemical identity · high-purity active material · analytical quantification · reproducible experimental conditions · controlled concentration · mechanistic research For this reason, CQHERB can position the product not simply as an ordinary Astragalus root extract, but as a specialized high-purity Astragalus-derived active ingredient.     3. Why Is Cycloastragenol Attracting Attention in the U.S.? The U.S. market shows interest in Cycloastragenol from several different directions. 3.1 Research Chemical Market Cycloastragenol is already available through major U.S.-facing scientific suppliers. For example: · Sigma-Aldrich lists Cycloastragenol ≥98% HPLC. · TCI America lists Cycloastragenol as a research chemical. · Cayman Chemical offers Cycloastragenol for research use. · VWR lists multiple Cycloastragenol products from research suppliers. This creates a clear B2B opportunity for suppliers capable of offering: high purity + consistent batches + analytical documentation + competitive bulk pricing.     4. Cycloastragenol and the U.S. Healthy-Aging Market Beyond laboratory research, Cycloastragenol has become associated with the broader healthy-aging and longevity ingredient category. Current U.S. consumer products illustrate this positioning. For example, ProHealth Longevity markets a Cycloastragenol product at 10 mg per capsule and positions it around telomere and healthy-aging research. Other U.S.-market products emphasize: · telomere support · longevity · cellular health · healthy aging · antioxidant-related positioning · high-purity Cycloastragenol These commercial products demonstrate that Cycloastragenol is not limited to the laboratory-reagent market. Instead, it sits at the intersection of: Botanical Ingredients → Nutraceuticals → Healthy Aging → Longevity Research → Cellular Biology This makes Cycloastragenol particularly interesting for ingredient manufacturers and distributors targeting premium U.S. markets.     5. Cycloastragenol and Telomerase Research One of the most frequently studied characteristics of Cycloastragenol is its relationship with telomerase activity. Scientific research has reported that Cycloastragenol can stimulate telomerase activity in experimental systems. For example, research published in PubMed reported Cycloastragenol-associated telomerase activation in neuronal and cellular models. Another review described Cycloastragenol as a small-molecule telomerase activator and discussed its potential relevance to age-associated conditions, while also noting that further research is needed to clarify efficacy and potential adverse effects. This makes telomerase one of the most important scientific keywords associated with Cycloastragenol. Important distinction Telomerase research does not mean that a Cycloastragenol ingredient has been proven to reverse aging or extend human lifespan. For responsible B2B marketing, CQHERB recommends using language such as: “Cycloastragenol has been investigated for its effects on telomerase activity and cellular aging-related pathways.” rather than: “Cycloastragenol reverses aging.” This distinction is important for scientific credibility and regulatory risk management.     6. Emerging Research Areas Scientific literature has explored Cycloastragenol across multiple biological research areas. 6.1 Telomerase and Telomere Research This is currently one of the most recognizable research directions. Researchers have investigated: · telomerase activity · hTERT expression · telomere biology · cellular replicative capacity · aging-related cellular pathways     6.2 Oxidative Stress Research Research has also investigated the relationship between Cycloastragenol and oxidative stress pathways. A study reported that Cycloastragenol increased NRF2 nuclear localization and activity and affected downstream cytoprotective pathways in experimental models. This provides a scientific basis for investigating Cycloastragenol in: · oxidative stress research · cellular defense pathways · aging biology · NRF2-related research     6.3 Immune Cell Research Earlier research investigated Cycloastragenol-related telomerase activity and cellular function in human CD8+ T lymphocytes. Cayman Chemical's research documentation references work examining telomere loss, proliferative capacity and antiviral functions of CD8+ T cells. This area may be relevant to researchers studying: · immune-cell biology · T-cell function · cellular aging · telomere biology     6.4 Bone and Osteogenic Research Experimental studies have also examined Cycloastragenol in bone-related models. One study reported effects on osteogenic differentiation and mineralization through a telomerase-associated mechanism in cell and zebrafish models. This remains an area of preclinical research, rather than established clinical treatment.     7. U.S. Market Evidence: Is There Real Commercial Interest? Rather than relying on unsupported market-size estimates, several concrete indicators can be observed. Indicator 1: Major U.S. Research Suppliers Cycloastragenol is commercially listed by multiple established scientific suppliers serving the U.S. market. Examples include: · Sigma-Aldrich · TCI America · Cayman Chemical · VWR/Avantor distribution channels Indicator 2: U.S. Consumer Products Cycloastragenol is also sold in U.S.-market supplements positioned around longevity and healthy aging. Indicator 3: Historical U.S. Regulatory Activity FDA's public list of New Dietary Ingredient notifications includes a 2010 notification concerning a concentrated Astragalus membranaceus extract containing more than 95% Cycloastragenol for TA-65®. This is an important historical market signal because it shows that Cycloastragenol-rich Astragalus ingredients have been considered within the U.S. dietary-ingredient regulatory framework. However, an NDI notification should not be described as FDA approval. FDA explains that when an ingredient qualifies as a new dietary ingredient, manufacturers or distributors may have notification obligations and must establish a reasonable expectation of safety under the proposed conditions of use.     8. What Are U.S. Buyers Looking for in Cycloastragenol? For CQHERB, this is perhaps the most important commercial section. Based on the current U.S. supplier landscape, buyers can be divided into several groups. 1. Nutraceutical Ingredient Companies These companies may be looking for: · bulk Cycloastragenol · standardized Astragalus extract · high-purity material · stable supply · documentation · private-label ingredient support 2. Dietary Supplement Manufacturers Potential applications include formulations positioned around: · healthy aging · longevity research · cellular health · telomere research 3. Research Institutions Researchers may require: · ≥98% purity · analytical characterization · COA · HPLC data · MS data · NMR data · SDS · batch traceability 4. Ingredient Distributors Distributors typically prioritize: · competitive pricing · MOQ flexibility · reliable lead time · export documentation · repeatable specifications · private-label or OEM support     9. Why High-Purity Cycloastragenol Matters For a specialized botanical active, purity is only one part of quality. A professional supplier should be able to provide evidence for: Chemical Identity · Correct botanical source · Correct chemical identity · CAS/reference number · Molecular formula · Molecular weight Purity HPLC or another validated analytical method should be used to quantify the target compound. Commercial U.S. suppliers currently list Cycloastragenol products at ≥98% HPLC, establishing this as a recognizable research-grade specification. Batch-to-Batch Consistency For commercial formulation, consistent purity between batches is critical. Contaminant Control Depending on the intended market, buyers may request: · Heavy metals · Residual solvents · Microbial testing · Pesticide residues · Mycotoxins · Other botanical contaminants Documentation A professional B2B package may include: · COA · Specification Sheet · SDS · HPLC chromatogram · MS data · NMR data · Certificate of Origin · Manufacturing information     10. Cycloastragenol CAS Number: An Important Buyer Check This deserves a separate section because it can cause confusion during international sourcing. Different scientific databases and commercial suppliers currently display different CAS associations for Cycloastragenol. For example: · FDA's Substance Registration System identifies Cycloastragenol with UNII X37D9F2L0V and lists 78574-94-4 among its synonyms/mappings. · Sigma-Aldrich lists a Cycloastragenol product under CAS 78574-94-4. · NLM's MeSH database associates Cycloastragenol with 84605-18-5. · Sigma-Aldrich also has a separate product record under 84605-18-5. Therefore, professional buyers should verify CAS, stereochemical identity, InChIKey, analytical data and supplier documentation together, rather than relying on the CAS number alone. For CQHERB's final product page, I recommend using the exact identity appearing on your own: COA + Specification + HPLC + MS/NMR documentation. This will make the product page much more credible to U.S. technical buyers.     11. Cycloastragenol vs Astragaloside IV These two ingredients are often confused because they are both associated with Astragalus. Feature Cycloastragenol Astragaloside IV Category Triterpenoid sapogenin Triterpenoid saponin Botanical association Astragalus Astragalus Molecular Formula C₃₀H₅₀O₅ Different molecular structure Research focus Telomerase, cellular aging, signaling Saponin/pharmacological research Typical positioning High-purity active / longevity research Astragalus saponin research Commercial form Powder / high-purity compound Powder / standardized extract Buyer priority Purity & chemical identity Purity & standardized content Cycloastragenol is particularly attractive when a customer wants a defined active molecule rather than a broad-spectrum Astragalus extract.     12. Potential Applications for Cycloastragenol CQHERB can position Cycloastragenol for several B2B applications. Nutraceutical Research · Healthy-aging formulations · Longevity-oriented products · Cellular health formulations · Botanical active research Research & Development · Telomerase research · Telomere biology · Cellular aging · Oxidative stress · NRF2-related research · Immune-cell research Cosmetic Research Potential research interest may include: · skin aging · cellular protection · skin barrier research · oxidative stress · fibroblast/keratinocyte models These should be described as research and formulation applications, not as established disease-treatment claims.     13. How to Choose a Cycloastragenol Supplier When sourcing Cycloastragenol internationally, buyers should ask at least the following questions: 1. What is the exact chemical identity? Ask for: · CAS · Molecular formula · Molecular weight · Structure · InChIKey if available 2. What is the actual purity? Do not rely only on: “98% Cycloastragenol” Ask: 98% by which analytical method? 3. Can the supplier provide HPLC data? A chromatogram provides substantially more information than a simple specification statement. 4. Is the product botanical-derived or synthetic? This distinction can be commercially important depending on the application. 5. What is the source plant? For botanical material, buyers should confirm: Astragalus membranaceus and the relevant plant part, such as root. 6. Can the supplier provide batch documentation? A professional B2B supplier should be able to provide relevant documentation upon request.     14. Why Work With CQHERB for Cycloastragenol? At CQHERB, our positioning is not simply: “We sell Cycloastragenol.” Our goal is to provide research-oriented botanical ingredients with transparent specifications and professional technical support. For Cycloastragenol buyers, CQHERB can support projects requiring: High-Purity Cycloastragenol Suitable for research, ingredient development and specialized formulation projects. Astragalus-Based Botanical Ingredients For customers who need broader Astragalus extracts rather than isolated Cycloastragenol. Technical Documentation Available documentation can include: · COA · Specification Sheet · SDS · Analytical information · Botanical source information · Batch information Flexible B2B Supply We can support different purchasing requirements, from: Laboratory Samples → Small R&D Orders → Pilot Projects → Commercial Bulk Supply International B2B Support CQHERB is positioned to support overseas buyers with: · Product selection · Technical documentation · Sample evaluation · Packaging · Export support · Bulk quotation     15. CQHERB Technical Insight Why Cycloastragenol Is Different From a Conventional Astragalus Extract A conventional botanical extract contains a complex mixture of compounds. Cycloastragenol provides a more specific chemical target. This distinction can be important for: Research reproducibility and formulation standardization. For research applications, a defined compound allows researchers to better control: · concentration · dose · experimental conditions · analytical measurement · batch comparison For commercial formulations, a defined active may also make it easier to establish a consistent ingredient specification. This is one reason high-purity Cycloastragenol can occupy a different commercial position from a conventional Astragalus root extract.     16. U.S. Market Positioning Strategy for Cycloastragenol For the U.S. market, we recommend positioning Cycloastragenol around four major themes: 01 — Healthy Aging The strongest consumer-facing category. 02 — Telomerase Research The strongest scientific keyword. 03 — Premium Botanical Active The strongest ingredient-industry positioning. 04 — High-Purity B2B Supply The strongest commercial positioning for CQHERB. This creates a clear product story: Astragalus → Cycloastragenol → Telomerase Research → Healthy Aging → Premium Botanical Ingredient → B2B Supply     17. Regulatory Considerations for the U.S. Market This point should be handled carefully on a professional B2B website. FDA distinguishes dietary supplements from drugs. Dietary supplements fall under the food regulatory framework, while products intended to diagnose, cure, mitigate, treat or prevent disease may fall into drug territory. For ingredients that qualify as new dietary ingredients, FDA's NDI framework may require premarket notification and information supporting a reasonable expectation of safety under the proposed conditions of use. Therefore, CQHERB should avoid statements such as: ❌ “Cycloastragenol treats aging.” ❌ “Cycloastragenol cures age-related diseases.” ❌ “Clinically proven to extend human lifespan.” Instead, use: ✅ “Cycloastragenol has been investigated for telomerase activity.” ✅ “Cycloastragenol is a research-active compound associated with Astragalus.” ✅ “Research has explored its potential relevance to cellular aging pathways.” This approach makes the website more suitable for both scientific audiences and international B2B buyers.     18. Frequently Asked Questions What is Cycloastragenol? Cycloastragenol is a naturally occurring triterpenoid sapogenin associated with Astragalus species, particularly Astragalus membranaceus. Is Cycloastragenol the same as Astragalus extract? No. Astragalus extract is a complex botanical preparation, while Cycloastragenol is a specific triterpenoid constituent associated with Astragalus. What is Cycloastragenol used for? Cycloastragenol is studied in areas including telomerase activity, cellular aging, oxidative stress and immune-cell biology. Is Cycloastragenol popular in the U.S.? There is clear commercial and research activity in the U.S. market. Major scientific suppliers and U.S. nutraceutical companies currently offer Cycloastragenol products. What purity should I buy? For research and specialized ingredient applications, ≥98% HPLC is a commonly encountered high-purity specification among commercial research suppliers. Can Cycloastragenol be used in dietary supplements? The regulatory status depends on the exact ingredient, formulation, intended use, labeling and applicable U.S. requirements. Buyers should conduct a product-specific regulatory review rather than assuming that commercial availability equals FDA approval. FDA's NDI framework is relevant where an ingredient qualifies as a new dietary ingredient. Does Cycloastragenol extend human lifespan? Current scientific literature does not establish that Cycloastragenol extends human lifespan. Research has primarily focused on biological mechanisms such as telomerase activity and cellular pathways. What documents should I request from a supplier? At minimum: · COA · Specification Sheet · HPLC · SDS · Botanical source · Batch information · Heavy-metal testing where applicable · Residual-solvent testing where applicable     19. Why Choose CQHERB Cycloastragenol? If you are sourcing Cycloastragenol for nutraceutical development, botanical research, healthy-aging formulations or commercial ingredient applications, CQHERB can provide a professional B2B supply solution. Our focus is: High Purity Consistent Quality Transparent Documentation Reliable Supply Technical Support Global B2B Service Whether you need a laboratory sample, a development batch or commercial-volume supply, our team can work with you to determine the appropriate Cycloastragenol specification for your project.     20. Conclusion Cycloastragenol represents an important specialized ingredient at the intersection of Astragalus botanical science, telomerase research, healthy aging and the growing longevity-oriented ingredient market. The U.S. market already provides several signals of commercial interest: Cycloastragenol is listed by established scientific suppliers, appears in U.S. nutraceutical products and has a history of regulatory interaction through an NDI notification involving a Cycloastragenol-rich Astragalus extract. For B2B buyers, however, the opportunity is closely connected to quality and documentation. A reliable Cycloastragenol supplier should provide more than a purity number. Buyers should evaluate chemical identity, analytical methodology, botanical source, batch consistency and supporting documentation. CQHERB aims to provide Cycloastragenol and Astragalus-derived botanical ingredients for international research, nutraceutical and ingredient-development markets, with a focus on quality, transparency and reliable B2B supply.  

Dimethylcurcumin (ASC-J9) CAS 52328-98-0: Chemical Properties, Androgen Receptor Research, Applications & Buying Guide A Research-Oriented Guide to a Curcumin Analogue and Androgen Receptor Degradation Enhancer CAS No. 52328-98-0 | Molecular Formula C23H24O6 | Molecular Weight 396.43 g/mol     Quick Answer Dimethylcurcumin, commonly known as ASC-J9 or GO-Y025, is a synthetic curcumin analogue that has been extensively investigated in laboratory and preclinical research related to androgen receptor (AR) signaling. Its chemical identity is associated with CAS No. 52328-98-0, molecular formula C23H24O6, and molecular weight 396.43 g/mol. Unlike conventional androgen receptor antagonists that primarily interfere with androgen binding or receptor signaling, ASC-J9 has been investigated as an androgen receptor degradation enhancer. Research has examined its ability to promote degradation of androgen receptor proteins and thereby alter AR-dependent signaling in experimental models. Published studies have investigated ASC-J9 in a range of experimental systems, including prostate cancer models, androgen receptor-associated disorders, bladder cancer models, and spinal and bulbar muscular atrophy research. These studies include in vitro cellular experiments and in vivo animal models; such findings should not be interpreted as evidence of established clinical efficacy in humans. For researchers and organizations sourcing Dimethylcurcumin, important purchasing considerations include chemical identity, purity, analytical characterization, batch consistency, storage conditions, and supporting technical documentation.     Key Takeaways · Dimethylcurcumin is also known as ASC-J9 and GO-Y025. · CAS Number: 52328-98-0. · Molecular Formula: C23H24O6. · Molecular Weight: 396.43 g/mol. · It is a synthetic curcumin analogue, rather than native curcumin itself. · ASC-J9 has been investigated as an androgen receptor degradation enhancer. · Published research has examined its effects on AR protein degradation and AR-related signaling. · Research has included prostate cancer, bladder cancer, spinal and bulbar muscular atrophy, and other AR-associated experimental models. · Research-grade ASC-J9 is commonly supplied as a solid/powder and may require low-temperature storage depending on the supplier's specification. · Analytical verification is important when purchasing high-purity Dimethylcurcumin for research. · ASC-J9 should be presented on a research-oriented website as a research compound, not as an approved therapeutic product.     1. What Is Dimethylcurcumin (ASC-J9)? Dimethylcurcumin is a synthetic compound structurally related to curcumin and is widely known in the scientific literature as ASC-J9. The compound is identified chemically as: (1E,4Z,6E)-1,7-bis(3,4-dimethoxyphenyl)-5-hydroxyhepta-1,4,6-trien-3-one Public chemical databases list Dimethylcurcumin, ASC-J9, and GO-Y025 among its synonyms. PubChem identifies CAS No. 52328-98-0 and molecular formula C23H24O6, with a molecular weight of approximately 396.4 g/mol. Commercial research suppliers also identify ASC-J9 using the same CAS number and molecular formula and commonly describe high-purity material as a research-grade powder. Although its name contains "curcumin," Dimethylcurcumin should not be treated as simply another commercial grade of curcumin. It is a distinct synthetic curcumin analogue with its own molecular structure and research profile. This distinction is particularly important for purchasing, analytical testing, literature searches, and regulatory documentation.     2. Dimethylcurcumin vs. Curcumin The relationship between Dimethylcurcumin and curcumin is an important point for researchers. Curcumin is a naturally occurring diarylheptanoid associated with Curcuma longa. Dimethylcurcumin, by contrast, is a chemically modified analogue that contains methoxy-substituted aromatic groups and has a different molecular formula and molecular weight. Property Dimethylcurcumin / ASC-J9 Curcumin Common Name Dimethylcurcumin Curcumin CAS 52328-98-0 458-37-7 Formula C23H24O6 C21H20O6 Molecular Weight 396.43 g/mol 368.38 g/mol Relationship Synthetic curcumin analogue Naturally occurring curcuminoid Research Focus AR degradation and AR-related signaling Broad pharmacological and biochemical research Research Status Experimental/research compound Widely studied natural compound The two compounds therefore should not be substituted for one another simply because they belong to the broader curcumin-analogue research area.     3. Chemical Identification of ASC-J9 Accurate chemical identification is particularly important for research compounds because different suppliers may use overlapping synonyms. Core Chemical Information Property Information Product Name Dimethylcurcumin Common Research Name ASC-J9 Alternative Name GO-Y025 CAS Number 52328-98-0 Molecular Formula C23H24O6 Molecular Weight 396.43 g/mol Chemical Class Curcumin analogue IUPAC Name (1E,4Z,6E)-1,7-bis(3,4-dimethoxyphenyl)-5-hydroxyhepta-1,4,6-trien-3-one Physical Form Solid / powder Research Target Androgen receptor-related research The identity and molecular information above are supported by PubChem and commercial analytical product records.     4. Why Is ASC-J9 Important in Research? The scientific interest surrounding ASC-J9 largely comes from its unusual relationship with the androgen receptor. The androgen receptor (AR) is a nuclear receptor that regulates gene transcription in response to androgen hormones. AR signaling has important physiological roles and has also been extensively investigated in diseases and biological conditions in which androgen signaling is altered. ASC-J9 attracted research attention because studies indicated that it could promote AR protein degradation, rather than simply competing with androgens for receptor binding. This creates an important conceptual distinction: ASC-J9 research focuses on changing the abundance and activity of AR protein, while conventional antiandrogen research often focuses on blocking receptor activation. Early research demonstrated that ASC-J9 could disrupt interactions between AR and selected coregulators and increase AR degradation in experimental systems. Subsequent studies expanded this research into additional AR-associated models.     5. How Does ASC-J9 Work in Experimental Research? AR Degradation as a Research Mechanism One of the defining characteristics of ASC-J9 is its reported ability to enhance degradation of androgen receptor protein. Research has suggested that ASC-J9 can interfere with interactions between AR and selected coregulators, leading to increased AR degradation. Experimental work has also linked ASC-J9-mediated AR degradation to proteasome-dependent processes. This mechanism is different from simply reducing androgen production. The conceptual pathway can be simplified as: ASC-J9 ↓ Alteration of AR–coregulator interactions ↓ Enhanced AR degradation ↓ Reduced AR protein abundance ↓ Changes in AR-dependent transcription ↓ Changes in downstream cellular responses This model has been investigated primarily through laboratory and animal studies.     6. What Does the Scientific Literature Show? Research on ASC-J9 spans more than a decade. An early study published in Nature Medicine investigated ASC-J9 in a model of spinal and bulbar muscular atrophy. The study reported that ASC-J9 disrupted interactions between androgen receptor and coregulators and increased degradation of the mutant androgen receptor in experimental systems. The researchers also investigated the compound in transgenic mice. Later research examined ASC-J9 in prostate cancer models. Studies reported degradation of both full-length AR and an AR splice variant in experimental prostate cancer cell models, accompanied by reduced AR transcriptional activity and cell growth. Additional preclinical studies investigated ASC-J9 in combination with other experimental approaches, including radiation and chemotherapy models. For example, research published in Cancer Letters examined the combination of ASC-J9 with docetaxel in castration-resistant prostate cancer models. A review published in 2021 summarized research involving ASC-J9 across multiple AR-associated disease models, including prostate cancer, benign prostatic hyperplasia, bladder cancer, liver disease, spinal and bulbar muscular atrophy, ovarian cancer, and melanoma. Important Scientific Qualification These publications demonstrate research interest and preclinical findings, not established clinical efficacy. Therefore, CQHERB's website should describe ASC-J9 in terms such as: · Research compound · Research chemical · Curcumin analogue · AR degradation research · Experimental compound · Preclinical research and should avoid presenting ASC-J9 as an approved medicine or making direct therapeutic claims.     7. Research Applications of Dimethylcurcumin ASC-J9 has been investigated in several research areas. 7.1 Androgen Receptor Research This is the most characteristic research application. Researchers use ASC-J9 to investigate: · AR protein degradation · AR signaling · AR transcriptional activity · AR–coregulator interactions · AR-dependent cellular pathways     7.2 Prostate Cancer Research ASC-J9 has been investigated in multiple prostate cancer cell and animal models, including models of castration-resistant prostate cancer. Studies have examined whether AR degradation can alter tumor-cell proliferation and AR-dependent signaling. These findings remain within the context of experimental research and should not be presented as evidence that ASC-J9 is an approved cancer treatment.     7.3 Spinal and Bulbar Muscular Atrophy Research ASC-J9 has also been studied in models of spinal and bulbar muscular atrophy, a condition associated with mutant androgen receptor aggregation. The original study reported that ASC-J9 reduced mutant AR aggregation and improved disease-related phenotypes in experimental mice.     7.4 Bladder Cancer Research Research has also investigated ASC-J9 in bladder cancer models, particularly in relation to AR and NF-κB signaling and chemotherapy response.     8. Analytical Considerations for ASC-J9 For research-grade Dimethylcurcumin, chemical identity and purity should be verified through appropriate analytical methods. Commonly relevant analytical techniques include: HPLC HPLC can be used to evaluate chromatographic purity and batch consistency. LC-MS / MS Mass spectrometry can support molecular identity confirmation and quantitative analysis. A published analytical method specifically developed LC-MS/MS determination of ASC-J9 in mouse serum and tissues. NMR NMR can provide structural characterization and is particularly useful when confirming the identity of research compounds. COA A Certificate of Analysis should identify the product, batch, assay/purity, analytical method, and relevant quality parameters. For high-value research compounds, buyers should ideally review analytical documentation before placing larger orders.     CQHERB Technical Insight For Dimethylcurcumin and other research-oriented botanical or bioactive compounds, identity and analytical traceability should be considered alongside purity. A reliable research-material supplier should be able to clearly distinguish: Product identity → analytical method → purity → batch information → storage → documentation This is especially important for ASC-J9 because the compound is known under several names, including Dimethylcurcumin, ASC-J9 and GO-Y025. Using the CAS number 52328-98-0 together with the molecular formula and analytical documentation can help minimize purchasing and identification errors.     9. Storage and Handling Publicly available research-product specifications commonly recommend storing ASC-J9 at low temperature, with −20°C being specified by several commercial research suppliers. For commercial research material, customers should follow the supplier-specific COA, SDS and storage instructions rather than relying on a generic recommendation. Recommended purchasing documentation should include: · Product specification · COA · SDS/MSDS · Storage conditions · Batch number · Retest or expiry information where applicable · Analytical data upon request     10. Who Uses Dimethylcurcumin? ASC-J9 is primarily relevant to organizations conducting laboratory and preclinical research. Potential users include: · University research laboratories · Pharmaceutical research organizations · Biotechnology companies · Molecular biology laboratories · Cancer biology research groups · Androgen receptor research laboratories · Drug discovery teams · Academic research institutions The appropriate use and regulatory status depend on the customer's jurisdiction, research protocol, and intended application.     11. Buyer Guide: How to Evaluate an ASC-J9 Supplier When sourcing Dimethylcurcumin, buyers should not evaluate suppliers based solely on the advertised purity number. A more complete evaluation should include: 1. Correct Chemical Identity Confirm: CAS 52328-98-0 and cross-check the molecular formula and analytical data. 2. Purity Method Ask whether the stated purity is determined by HPLC or another analytical method. 3. Batch Documentation Request a current COA corresponding to the actual batch. 4. Structural Confirmation For research-grade material, MS and/or NMR data can provide additional confidence in chemical identity. 5. Storage Confirm storage temperature and packaging conditions. 6. Supply Consistency For repeated research programs, batch-to-batch consistency can be more important than obtaining the lowest initial quotation.     12. Why Research Buyers Should Distinguish ASC-J9 From Curcumin One common purchasing error is assuming that Dimethylcurcumin can be substituted with curcumin simply because ASC-J9 is a curcumin analogue. This is incorrect. The two compounds have different molecular formulas, molecular weights, structures, and research profiles. Therefore, research protocols specifying: ASC-J9 / Dimethylcurcumin / CAS 52328-98-0 should not automatically be replaced with curcumin or another curcuminoid. For reproducible experimental research, the exact compound specified in the protocol should be sourced and analytically verified.     13. Frequently Asked Questions What is ASC-J9? ASC-J9 is a research name for Dimethylcurcumin, a synthetic curcumin analogue investigated particularly for its ability to enhance androgen receptor degradation. What is the CAS number of ASC-J9? The CAS number is 52328-98-0. What is the molecular formula of Dimethylcurcumin? The molecular formula is C23H24O6. What is the molecular weight of ASC-J9? The molecular weight is approximately 396.43 g/mol. Is ASC-J9 the same as curcumin? No. ASC-J9 is a distinct synthetic curcumin analogue with a different molecular structure and molecular formula. What is ASC-J9 mainly researched for? ASC-J9 has been extensively investigated in androgen receptor-related research, particularly research involving AR degradation and signaling. Is ASC-J9 a conventional androgen receptor antagonist? Its research mechanism is distinct from conventional AR antagonists. ASC-J9 has primarily been investigated as an AR degradation enhancer, affecting AR protein abundance rather than simply blocking androgen binding. What research models have been used? Published research includes cell-based studies and animal models involving prostate cancer, spinal and bulbar muscular atrophy, bladder cancer, and other AR-associated conditions. How should ASC-J9 be stored? Several commercial research specifications recommend storage at approximately −20°C, but buyers should follow the storage instructions supplied with the specific batch. What documents should I request when purchasing ASC-J9? At minimum, buyers should consider requesting a COA and SDS/MSDS. For research applications, HPLC, MS and/or NMR information may also be useful.     14. References & Further Reading For the published scientific basis of this guide, useful starting points include: 1. Yang Z, et al. ASC-J9 ameliorates spinal and bulbar muscular atrophy phenotype via degradation of androgen receptor. Nature Medicine. 2. Lai KP, et al. Research on ASC-J9 and androgen receptor degradation in prostate cancer models. 3. Cheng MA, et al. Androgen receptor degradation enhancer ASC-J9® in an FDA-approved formulated solution suppresses castration resistant prostate cancer cell growth. Cancer Letters. 4. Hu H, Zhou H, Xu D. A review of the effects and molecular mechanisms of dimethylcurcumin (ASC-J9) on androgen receptor-related diseases. Chemical Biology & Drug Design. 2021. 5. Research on LC-MS/MS determination and pharmacokinetic distribution of ASC-J9 in experimental animals. 6. Research investigating ASC-J9 in combination with chemotherapy in experimental prostate cancer models.     Looking for Dimethylcurcumin (ASC-J9) for Research? CQHERB provides botanical extracts and research-oriented bioactive compounds for international customers, with technical documentation available according to product and batch. For Dimethylcurcumin (ASC-J9), CAS 52328-98-0, customers can discuss requirements such as: · Required purity · Research quantity · COA · HPLC analytical data · MS/NMR documentation where available · SDS/MSDS · Packaging · Storage requirements · International shipment requirements For research and formulation development, please contact the CQHERB technical sales team with your required quantity and specification.

Methyl Maslinate CAS 22425-82-7 | Maslinic Acid Methyl Ester Methyl Maslinate, also known as Maslinic Acid Methyl Ester or Crategolic Acid Methyl Ester, is a defined pentacyclic triterpenoid derivative identified by CAS No. 22425-82-7. It has the molecular formula C31H50O4 and a molecular weight of approximately 486.73 g/mol. For B2B buyers, Methyl Maslinate is best understood as a defined research compound associated with natural-product chemistry, rather than as a conventional multi-component botanical extract. CQ HERB supplies Methyl Maslinate for research, analytical and development applications with batch-specific documentation according to the agreed specification.     Quick Answer What is Methyl Maslinate? Methyl Maslinate is the methyl ester form of maslinic acid and is also known as Maslinic Acid Methyl Ester and Crategolic Acid Methyl Ester. The compound is identified by: CAS: 22425-82-7 Molecular Formula: C31H50O4 Molecular Weight: 486.73 g/mol Chemical Class: Pentacyclic triterpenoid derivative PubChem lists Methyl Maslinate under CID 3082208 and records its molecular structure, formula, synonyms and natural-product occurrence data.     Key Takeaways Product Name: Methyl Maslinate Chinese Name: 马斯里酸甲酯 Alternative Name: Maslinic Acid Methyl Ester Other Name: Crategolic Acid Methyl Ester CAS No.: 22425-82-7 Molecular Formula: C31H50O4 Molecular Weight: 486.73 g/mol Chemical Class: Pentacyclic triterpenoid derivative Form: Powder Typical Research Specification: ≥99% HPLC*, subject to batch specification Positioning: Research and analytical compound Documentation: COA, HPLC, SDS and TDS PubChem's current record confirms the chemical identity and reports natural-product occurrence data for Methyl Maslinate.     1. Chemical Identity Methyl Maslinate is a defined triterpenoid derivative rather than a generic plant extract. Basic Information Property Information Product Name Methyl Maslinate CAS Number 22425-82-7 Molecular Formula C31H50O4 Molecular Weight 486.73 g/mol Alternative Name Maslinic Acid Methyl Ester Other Name Crategolic Acid Methyl Ester Chemical Class Pentacyclic triterpenoid derivative Product Form Powder The molecular formula and molecular weight are supported by PubChem and other chemical reference sources.     2. Methyl Maslinate and Maslinic Acid Methyl Maslinate and maslinic acid are structurally related compounds, but they should not be treated as identical materials. Property Maslinic Acid Methyl Maslinate Chemical Type Pentacyclic triterpenoid Triterpenoid ester derivative CAS 4373-41-5 22425-82-7 Molecular Formula C30H48O4 C31H50O4 Molecular Weight Approx. 472.70 g/mol Approx. 486.73 g/mol Key Structural Feature Carboxylic acid Methyl ester Research Positioning Natural-product research Triterpenoid derivative research For procurement, researchers should always confirm the exact CAS number rather than relying on the generic term "maslinic acid."     3. Natural-Product Background Methyl Maslinate is associated with natural-product chemistry and has been reported in several plant-related datasets. PubChem's LOTUS-linked information records Methyl Maslinate or maslinic acid methyl ester in organisms including Isodon japonicus, Cunila lythrifolia and Prunella vulgaris. This information is useful for natural-product researchers, but natural occurrence should not automatically be interpreted as the manufacturing source of a commercial batch. Therefore, suppliers should clearly distinguish between: Natural occurrence and Manufacturing source For CQ HERB, the actual source and manufacturing route should be stated according to the specific product and production process.     4. Structural Information Methyl Maslinate belongs to the pentacyclic triterpenoid family. Its molecular formula is: C31H50O4 and its molecular weight is: 486.73 g/mol PubChem provides detailed structural information, including the compound's InChI, InChIKey, SMILES and systematic chemical name. This information can be useful when researchers compare Methyl Maslinate with related triterpenoids.     5. Why CAS 22425-82-7 Matters The term "maslinate" can be confusing because multiple related triterpenoid compounds may appear in natural-product literature. For procurement, buyers should confirm: CAS No.: 22425-82-7 and cross-check: Molecular formula Molecular weight Chemical structure HPLC purity COA Batch information This provides a more reliable basis for material identification.     6. Research Applications Methyl Maslinate can be positioned for several research contexts without making therapeutic or health claims. Natural-Product Chemistry Methyl Maslinate can be used as a defined triterpenoid-related compound in natural-product chemistry research. Analytical Research A characterized Methyl Maslinate material can be used where an analytical compound or reference material is required. Structural Research Its defined molecular structure allows researchers to compare it with related pentacyclic triterpenoids and ester derivatives. Biochemical Research Methyl Maslinate has appeared in scientific research involving biochemical and molecular systems. For commercial communication, these should be described as research contexts, rather than as evidence of a health benefit.     7. Methyl Maslinate as a Research Compound A key distinction between Methyl Maslinate and a conventional botanical extract is chemical definition. A botanical extract may contain multiple compounds, while an isolated Methyl Maslinate product is intended to provide a specific chemical entity with a defined molecular identity. This makes parameters such as: CAS number Purity HPLC profile Molecular formula Molecular weight Batch number particularly relevant to researchers.     8. HPLC and Quality Control For research-grade Methyl Maslinate, analytical characterization is an important part of supplier evaluation. CQ HERB can provide quality documentation according to the agreed specification, including: COA HPLC purity HPLC chromatogram SDS TDS Product specification Batch information Storage recommendations For customers requiring a specific analytical method, the testing requirements should be confirmed before production or shipment.     9. Appearance and Physical Form Methyl Maslinate is generally supplied as a powder or solid material. Public chemical databases and commercial references describe the compound as a solid material, while specific color descriptions may vary between suppliers. For CQ HERB's official product specification, the appearance and color should always correspond to the actual production batch. Recommended wording: Appearance: Powder If a specific color is confirmed by your current COA, that color can be added to the specification.     10. Storage and Handling Methyl Maslinate should be stored in a tightly sealed container under controlled conditions. General storage recommendations include: Keep dry. Protect from moisture. Protect from excessive light. Minimize prolonged exposure to air. Follow the storage conditions stated on the product SDS and COA. For long-term storage, the actual validated storage recommendation for the supplied batch should be followed.     11. How to Select a Methyl Maslinate Supplier 1. Confirm CAS Number 22425-82-7 2. Confirm Molecular Formula C31H50O4 3. Confirm Molecular Weight 486.73 g/mol 4. Check HPLC Purity Ask for the actual batch HPLC result rather than relying solely on a website specification. 5. Request COA A professional COA should identify the material and corresponding batch. 6. Request Supporting Documentation Depending on the application, buyers may require: COA HPLC chromatogram SDS TDS Product specification Batch information Export documentation     12. Methyl Maslinate vs. Other Triterpenoids Methyl Maslinate belongs to a broad group of pentacyclic triterpenoid-related compounds. For research procurement, compounds should not be selected solely by a general category such as "triterpenoid." Researchers should confirm the exact chemical identity. Parameter Methyl Maslinate CAS 22425-82-7 Formula C31H50O4 MW 486.73 g/mol Chemical Class Pentacyclic triterpenoid derivative Form Powder Research Position Defined research compound     13. Why Choose CQ HERB? CQ HERB supplies Methyl Maslinate for professional B2B research and development applications. Our supply support can include: Research-grade material Batch-specific COA HPLC testing SDS TDS Flexible packaging Small research quantities Bulk supply Export documentation Customized analytical requirements For customers evaluating Methyl Maslinate for a new project, we recommend confirming purity, quantity, packaging and documentation requirements before quotation.     Frequently Asked Questions What is Methyl Maslinate? Methyl Maslinate is a pentacyclic triterpenoid derivative also known as Maslinic Acid Methyl Ester or Crategolic Acid Methyl Ester. What is the CAS number of Methyl Maslinate? The CAS number is 22425-82-7. What is the molecular formula? The molecular formula is C31H50O4. What is the molecular weight? The molecular weight is approximately 486.73 g/mol. Is Methyl Maslinate the same as maslinic acid? No. Methyl Maslinate is a methyl ester derivative of maslinic acid and has a different molecular formula and molecular weight. Is Methyl Maslinate a plant extract? No. Methyl Maslinate is a defined chemical compound associated with natural-product chemistry. It should not be described simply as a conventional botanical extract. What is Methyl Maslinate used for? It is supplied primarily for research, analytical and natural-product chemistry applications. Can CQ HERB provide an Methyl Maslinate sample? Sample quantities can be discussed according to research requirements and current availability. What documentation is available? Typical documentation includes COA, HPLC data, SDS and TDS according to the applicable product specification.     Technical Data Summary Item Information Product Methyl Maslinate Alternative Name Maslinic Acid Methyl Ester Other Name Crategolic Acid Methyl Ester CAS 22425-82-7 Formula C31H50O4 Molecular Weight 486.73 g/mol Chemical Class Pentacyclic triterpenoid derivative Form Powder Purity ≥99% HPLC* Application Research & analytical use Documentation COA / HPLC / SDS / TDS * Subject to actual batch specification.     Research Use Disclaimer For Research Use Only. This product is supplied as a research and analytical material. It is not intended for human or veterinary use, diagnosis, treatment, cure, prevention of disease, or use as a pharmaceutical or dietary supplement unless separately authorized under applicable regulations.

Dimethylcurcumin (ASC-J9): Chemical Identity, Research Applications and Buyer Guide Dimethylcurcumin, also known as ASC-J9 or GO-Y025, is a defined chemical compound associated with curcumin-related chemical research. With CAS No. 52328-98-0, molecular formula C23H24O6, and molecular weight 396.43 g/mol, it is supplied as a research material for laboratory, analytical, biochemical, and chemical research. For researchers and B2B buyers evaluating Dimethylcurcumin, understanding its chemical identity, analytical specifications, documentation, and supply form is more important than relying on biological activity claims. CQ HERB supplies research-grade Dimethylcurcumin with batch-specific quality documentation according to the agreed specification.     Quick Answer What is Dimethylcurcumin (ASC-J9)? Dimethylcurcumin is a synthetic curcumin-related compound identified by CAS 52328-98-0. It is also known as: · ASC-J9 · ASC J9 · GO-Y025 · Dimethylcurcumin According to PubChem, Dimethylcurcumin has the molecular formula C23H24O6 and a molecular weight of approximately 396.43 g/mol. PubChem also records ASC-J9 and GO-Y025 among its synonyms. Unlike conventional curcumin obtained from botanical sources, Dimethylcurcumin should be described as a defined synthetic chemical compound, rather than as a conventional Curcuma longa extract.     Key Takeaways · Product Name: Dimethylcurcumin · Research Code: ASC-J9 · Alternative Name: GO-Y025 · CAS No.: 52328-98-0 · Molecular Formula: C23H24O6 · Molecular Weight: 396.43 g/mol · Appearance: Powder · Chemical Category: Curcumin-related synthetic compound · Typical Research Grade: ≥98% HPLC, subject to batch specification · Primary Positioning: Research and analytical material · Documentation: COA, HPLC data, SDS and TDS according to specification Commercial research suppliers also list ASC-J9 under CAS 52328-98-0 with ≥98% HPLC specifications.     1. Chemical Identity of Dimethylcurcumin Chemical identity is one of the most important factors when sourcing research compounds. Basic Information Property Information Product Name Dimethylcurcumin CAS Number 52328-98-0 Molecular Formula C23H24O6 Molecular Weight 396.43 g/mol Synonyms ASC-J9; GO-Y025 Chemical Type Synthetic curcumin-related compound Appearance Powder Research Use Laboratory and analytical research The molecular identity, CAS number, formula and molecular weight are supported by PubChem and other chemical reference databases.     2. Dimethylcurcumin vs. Curcumin Although the names are related, Dimethylcurcumin and conventional curcumin are different chemical compounds. Property Dimethylcurcumin Curcumin Common Name Dimethylcurcumin Curcumin CAS 52328-98-0 458-37-7 Molecular Formula C23H24O6 C21H20O6 Molecular Weight 396.43 g/mol 368.38 g/mol Chemical Position Synthetic curcumin-related compound Natural curcuminoid Typical Source Description Defined chemical compound Botanical-associated compound Research Positioning Research compound Natural-product / biochemical research This distinction is particularly important when purchasing material for analytical or laboratory work. A supplier should not describe Dimethylcurcumin simply as "curcumin" because the two compounds have different chemical identities.     3. Why CAS 52328-98-0 Matters A product name can sometimes be used inconsistently between suppliers. For procurement and laboratory work, the most reliable starting point is the CAS number: CAS No.: 52328-98-0 Buyers should cross-check the CAS number against: · Molecular formula · Molecular weight · Structural information · HPLC specification · COA · Batch information This helps reduce the risk of receiving a related but chemically different curcuminoid or research compound.     4. Structural Information Dimethylcurcumin is a defined organic molecule with the molecular formula C23H24O6. Its systematic chemical name is: (1E,4Z,6E)-1,7-bis(3,4-dimethoxyphenyl)-5-hydroxyhepta-1,4,6-trien-3-one PubChem records the structure, InChI, InChIKey, SMILES and related chemical identifiers for CAS 52328-98-0. For research projects involving structure-based analysis, these identifiers can be more useful than a commercial product name alone.     5. Research Context ASC-J9 has appeared in scientific and biochemical research involving molecular signaling and androgen receptor-related mechanisms. However, the presence of published research does not mean that a commercial Dimethylcurcumin product should be described as a therapeutic product. For responsible B2B communication, CQ HERB recommends describing ASC-J9 using neutral terminology such as: "Dimethylcurcumin is a research compound investigated in laboratory studies involving molecular signaling pathways." This wording identifies the scientific context without presenting experimental findings as a product benefit.     6. Research Applications Dimethylcurcumin may be relevant to several laboratory research contexts. Chemical Research Researchers can use Dimethylcurcumin as a defined chemical material for studies involving curcumin-related molecular structures and derivatives. Analytical Research A characterized Dimethylcurcumin material can be used where a defined analytical compound or reference material is required. Biochemical Research ASC-J9 has been investigated in laboratory research involving molecular and biochemical pathways. Comparative Research Dimethylcurcumin can also be included in comparative studies involving structurally related compounds. These descriptions refer to research contexts only and do not constitute therapeutic or medical claims.     7. HPLC and Quality Control For research compounds, identity and purity are critical procurement considerations. CQ HERB recommends evaluating Dimethylcurcumin using appropriate analytical methods, including HPLC where applicable. Typical documentation may include: · Certificate of Analysis (COA) · HPLC purity result · HPLC chromatogram · Product specification · SDS · TDS · Batch information · Storage recommendation For example, commercial research suppliers list ASC-J9 with ≥98% HPLC specifications. CQ HERB specifications should always be based on the actual production batch and current COA.     8. Appearance and Physical Form Dimethylcurcumin is generally supplied as a powder or solid material. Public chemical references report powder/solid physical forms, with color descriptions varying by source. For commercial specifications, the actual CQ HERB batch specification should take priority over generic database descriptions. A product specification may therefore state: Appearance: Powder with the specific color described according to the applicable batch COA.     9. Solubility and Laboratory Preparation Dimethylcurcumin has limited water solubility and may be prepared using suitable organic laboratory solvents depending on the experimental system. Published commercial reference information lists DMSO among solvents used for laboratory preparation. Researchers should select solvents and concentrations according to their own validated experimental protocols.     10. Storage and Handling Dimethylcurcumin should be stored according to the supplier's current product specification and SDS. Recommended general practices include: · Keep the container tightly closed. · Protect from moisture. · Protect from excessive light. · Store under controlled temperature conditions. · Avoid unnecessary repeated exposure to air. Some commercial research references recommend low-temperature storage for ASC-J9. The storage condition stated on the supplied COA, label and SDS should take precedence.     11. How to Select a Dimethylcurcumin Supplier When comparing suppliers, buyers should consider more than the stated purity. Check the CAS Number Confirm: 52328-98-0 Check the Molecular Formula Confirm: C23H24O6 Check the Molecular Weight Confirm: 396.43 g/mol Request HPLC Data Ask for the actual batch HPLC result and, when appropriate, the chromatogram. Request a COA The COA should identify the: · Product · CAS number · Batch number · Test result · Test method · Specification Check Documentation For international procurement, buyers may also need: · SDS · TDS · COA · HPLC chromatogram · Commercial invoice · Packing list · Export documentation     12. Why Choose CQ HERB? CQ HERB supplies Dimethylcurcumin for B2B research and development applications. Our support can include: · Research-grade material · Batch-specific COA · HPLC testing · SDS · TDS · Flexible packaging · Small research quantities · Bulk supply · Export documentation · Customized analytical requirements For projects requiring a specific purity or analytical method, buyers are encouraged to confirm the specification before placing an order.     Frequently Asked Questions What is ASC-J9? ASC-J9 is a research code name associated with Dimethylcurcumin, CAS 52328-98-0. Is ASC-J9 the same as curcumin? No. Dimethylcurcumin and curcumin are different chemical compounds with different molecular formulas and molecular weights. What is the CAS number of Dimethylcurcumin? The CAS number is 52328-98-0. What is the molecular formula? The molecular formula is C23H24O6. What is the molecular weight? The molecular weight is approximately 396.43 g/mol. Is Dimethylcurcumin a plant extract? No. CAS 52328-98-0 should be treated as a defined chemical compound rather than a conventional botanical extract. What is Dimethylcurcumin used for? It is supplied primarily as a research and analytical material for laboratory and chemical research. Can CQ HERB provide a COA? Yes. A batch-specific COA can be provided according to the applicable product specification. Is a sample available? Sample quantities can be discussed according to research requirements and current availability.     Technical Data Summary Item Information Product Dimethylcurcumin Research Code ASC-J9 Alternative Name GO-Y025 CAS 52328-98-0 Formula C23H24O6 Molecular Weight 396.43 g/mol Form Powder Purity ≥98% HPLC* Application Research & analytical use Documentation COA / HPLC / SDS / TDS * Subject to actual batch specification.     Research Use Disclaimer For Research Use Only. This product is supplied as a research and analytical material. It is not intended for human or veterinary use, diagnosis, treatment, cure, prevention of disease, or use as a pharmaceutical or dietary supplement unless separately authorized under applicable regulations.

    Oridonin (98%) Ultimate Guide A Technical Guide to Structure, Natural Sources, Research, Production, Quality Control and Supplier Selection Oridonin is a naturally occurring diterpenoid isolated primarily from Isodon rubescens, a plant traditionally known in China as Dong Ling Cao. It has attracted substantial scientific interest because of its distinctive ent-kaurane-type molecular framework, diverse natural-product chemistry, and extensive research across molecular biology, pharmacology, pharmaceutical chemistry, and drug-discovery research. For manufacturers and research organizations, however, understanding Oridonin requires more than reviewing its reported biological activities. The quality of a commercial Oridonin material depends on its botanical source, extraction and purification process, analytical methodology, purity specification, batch consistency, and supporting technical documentation. This guide provides a research-oriented overview of Oridonin, with particular attention to high-purity 98% Oridonin, including its chemical identity, natural source, physicochemical characteristics, production considerations, analytical quality control, research applications, and practical supplier evaluation.     Quick Answer What Is Oridonin? Oridonin is a naturally occurring ent-kaurane-type diterpenoid primarily associated with Isodon rubescens, a member of the Lamiaceae family. Its CAS number is 28957-04-2, molecular formula is C20H28O6, and molecular weight is approximately 364.4 g/mol. Oridonin is one of the most extensively studied diterpenoids found in Isodon rubescens. Modern research has investigated its molecular interactions, cellular pathways, pharmacokinetic characteristics, structural modifications, and potential applications in natural-product and pharmaceutical research. From a commercial perspective, high-purity Oridonin is different from a conventional Isodon rubescens or Dong Ling Cao extract. A standardized botanical extract contains multiple naturally occurring constituents, whereas 98% Oridonin is a purified single compound with a defined molecular identity and a much narrower analytical specification. This distinction makes high-purity Oridonin particularly relevant to laboratories and manufacturers that require reproducible research materials, defined chemical composition, and quantitative analytical control. For buyers, evaluating Oridonin quality should therefore go beyond the stated purity. Important considerations include HPLC methodology, chromatographic profile, identity confirmation, residual solvents, heavy metals, moisture, storage conditions, batch consistency, and the supplier's ability to provide complete technical documentation.     Key Takeaways Oridonin is a naturally occurring diterpenoid primarily associated with Isodon rubescens. CAS 28957-04-2 is the commonly recognized CAS identifier for Oridonin. Its molecular formula is C20H28O6, with a molecular weight of approximately 364.4 g/mol. Kew's Plants of the World Online currently accepts Isodon rubescens as the species name, while Rabdosia rubescens is treated as a synonym. Oridonin belongs to the ent-kaurane diterpenoid family. Isodon rubescens contains numerous diterpenoids and other secondary metabolites, with Oridonin among its best-studied constituents. High-purity Oridonin and Isodon rubescens extract are not interchangeable products. HPLC is an important analytical tool for evaluating Oridonin purity and the quality of Isodon rubescens-derived materials. Research on Oridonin includes natural-product chemistry, molecular mechanisms, pharmacokinetics, structural modification, and drug-discovery studies. Its relatively limited aqueous solubility and bioavailability remain important considerations in pharmaceutical research. For B2B procurement, purity should be evaluated together with identity, analytical methodology, documentation, and batch consistency.     Table of Contents What Is Oridonin? Why Is Oridonin Scientifically Important? Oridonin Chemical Structure and Properties Natural Source: Isodon rubescens Oridonin vs. Isodon rubescens Extract How Is High-Purity Oridonin Produced? Oridonin Quality Standards and HPLC Analysis Oridonin Solubility and Stability Considerations Research Applications of Oridonin Oridonin Derivatives and Structural Modification How to Choose a Reliable Oridonin Supplier Buyer Checklist for Oridonin 98% Frequently Asked Questions CQHERB Technical Insight Scientific References     1. What Is Oridonin? Oridonin is a naturally occurring diterpenoid found primarily in Isodon rubescens. It belongs to a structurally diverse family of plant-derived diterpenes and is characterized as an ent-kaurane-type diterpenoid. The compound has been extensively investigated because of its distinctive polycyclic molecular framework and multiple oxygen-containing functional groups. These structural characteristics make Oridonin an important subject in natural-product chemistry and medicinal chemistry research. The accepted botanical name is currently Isodon rubescens (Hemsl.) H.Hara, according to the Royal Botanic Gardens, Kew. Rabdosia rubescens is treated by Kew as a synonym. Both names therefore appear frequently in scientific publications and commercial literature. Definition Oridonin is a naturally occurring ent-kaurane diterpenoid with the molecular formula C20H28O6 and CAS 28957-04-2, primarily isolated from Isodon rubescens.     2. Why Is Oridonin Scientifically Important? Oridonin has attracted sustained scientific attention for several reasons. First, it represents a structurally distinctive natural-product scaffold. Second, it can be isolated and purified as a chemically defined compound, allowing researchers to investigate its molecular properties independently of the many other constituents found in the plant. Third, a substantial body of research has investigated Oridonin in cellular, biochemical, pharmacokinetic, and medicinal-chemistry contexts. Reviews published in recent years have summarized research involving signaling pathways, cell-cycle regulation, apoptosis, autophagy, oxidative processes, and other molecular phenomena. Importantly, much of this literature concerns preclinical or experimental research. Findings from cell models or animal studies should not automatically be interpreted as evidence of established clinical efficacy in humans. This distinction is particularly important when presenting Oridonin on a commercial website.     Why Does High-Purity Oridonin Matter? Research reproducibility is strongly influenced by material consistency. A crude botanical extract can contain numerous compounds whose concentrations vary according to: Plant origin Cultivar or genetic background Growing conditions Harvesting period Extraction method Processing conditions Storage A purified Oridonin material reduces many of these variables by providing a defined target compound. For laboratory and formulation-development work, high-purity Oridonin can therefore offer: Defined chemical identity Standardized purity Better batch-to-batch consistency More reproducible analytical results Easier comparison between experiments More precise formulation calculations     Scientific Research Timeline Research Stage General Development Early natural-product research Isolation and structural characterization of Oridonin Later phytochemical research Expansion of research on Isodon diterpenoids Modern analytical research Improved HPLC and LC-MS characterization Molecular research era Increasing investigation of cellular and signaling mechanisms Recent research Structural modification, delivery systems, pharmacokinetics, and drug-discovery studies The continuing development of analytical and biochemical technologies has allowed researchers to investigate Oridonin at increasingly detailed molecular levels. Section Summary Oridonin is scientifically important not simply because it originates from a traditional medicinal plant, but because it combines a distinctive natural-product structure with extensive experimental research and the ability to be isolated as a defined compound.     3. Oridonin Chemical Structure and Physicochemical Properties Basic Chemical Information Property Information Common Name Oridonin CAS Number 28957-04-2 Molecular Formula C20H28O6 Molecular Weight 364.4 g/mol Chemical Class ent-Kaurane diterpenoid Natural Source Isodon rubescens Typical High-Purity Specification ≥98% by HPLC The molecular identity and basic chemical information are consistent with the PubChem record for Oridonin.     What Makes the Oridonin Structure Interesting? Oridonin possesses a complex tetracyclic diterpenoid framework containing several oxygenated functional groups and an enone-related structural motif. This combination of structural features contributes to the compound's importance in medicinal-chemistry research. Researchers have also used the Oridonin scaffold as a starting point for chemical modification. Various derivatives have been investigated with the goal of modifying properties such as solubility, stability, pharmacokinetics, and biological activity.     Key Definitions DiterpenoidA natural product generally derived from four isoprene units and containing 20 carbon atoms. ent-Kaurane diterpenoidA structural class of diterpenoids characterized by a specific tetracyclic carbon skeleton. HPLCHigh-Performance Liquid Chromatography, an analytical technique commonly used to separate, identify, and quantify components in a sample. PurityThe proportion of the target compound relative to other detectable components under a defined analytical method.     Section Summary Oridonin's defined molecular formula and distinctive ent-kaurane diterpenoid structure make it suitable for detailed analytical and medicinal-chemistry research. Its structural framework has also become a useful starting point for investigating chemically modified derivatives.     4. Natural Source: Isodon rubescens What Plant Produces Oridonin? The principal natural source associated with Oridonin is Isodon rubescens (Hemsl.) H.Hara, a species in the Lamiaceae family. Kew currently recognizes Isodon rubescens as the accepted name and lists Rabdosia rubescens as a synonym. The species is native to central and southern China. The plant is commonly known in Chinese contexts as Dong Ling Cao (冬凌草), and the dried aerial parts have a long history of use in traditional Chinese medicine.     Phytochemical Complexity of Isodon rubescens One important point for buyers is that Isodon rubescens is not an Oridonin-only plant. Scientific reviews have documented a large number of secondary metabolites from the species, including: Diterpenoids Triterpenoids Phenolic compounds Alkaloids Volatile constituents Other specialized metabolites Among these constituents, diterpenoids represent one of the most extensively studied groups, with Oridonin being one of the best-known compounds.     Why Botanical Source Matters The concentration of individual compounds in a botanical raw material can vary according to: Plant genetics Geographic origin Cultivation conditions Harvest time Plant part Drying conditions Extraction technology Research on Rabdosia rubescens has also demonstrated that the contents of several compounds can vary among different cultivars, reinforcing the importance of analytical quality control. Section Summary Isodon rubescens is the principal botanical source associated with Oridonin. Because the plant contains a complex mixture of diterpenoids and other secondary metabolites, high-purity Oridonin requires dedicated extraction and purification rather than simple botanical extraction.     5. Oridonin vs. Isodon rubescens Extract This distinction is particularly important for international buyers. Feature Oridonin 98% Isodon rubescens Extract Product Type Purified single compound Multi-component botanical extract Main Target Oridonin Multiple plant constituents Purity Specification Typically expressed as Oridonin % by HPLC May use extract ratio or marker-compound specification Chemical Composition Narrowly defined Complex Research Reproducibility High when analytical method is controlled Dependent on extract specification Typical Use Research, analytical and formulation development Botanical ingredient research and formulation Quality Control HPLC, identity, impurities and other specifications Marker compounds, extraction ratio, contaminants and other specifications Buyer Tip If a project requires a defined concentration of Oridonin, purchasing a standardized high-purity Oridonin material is generally more straightforward than relying on a conventional Isodon rubescens extract. If the project specifically requires the broader phytochemical profile of the plant, a standardized botanical extract may be more appropriate. Section Summary Oridonin 98% and Isodon rubescens extract should not be treated as equivalent products. The former is a purified compound; the latter is a complex botanical preparation with multiple constituents.     6. How Is High-Purity Oridonin Produced? From Botanical Raw Material to Purified Compound The production of high-purity Oridonin requires several stages because the target compound occurs together with numerous other constituents in the plant. A simplified production concept is: Botanical Raw Material ↓ Extraction ↓ Filtration / Concentration ↓ Fractionation ↓ Purification ↓ Crystallization or Further Refinement ↓ Drying ↓ HPLC Testing ↓ High-Purity Oridonin The exact process depends on the manufacturer's technology, raw material specification, target purity, scale, and analytical requirements.     Extraction The first objective is to transfer Oridonin and related constituents from the plant matrix into an appropriate extract. Extraction parameters may influence: Yield Impurity profile Solvent consumption Downstream purification requirements     Purification Crude extracts contain many naturally occurring compounds. Therefore, achieving a high Oridonin specification requires selective separation from: Other diterpenoids Pigments Phenolic constituents Lipophilic components Other plant-derived impurities Published research has demonstrated the use of chromatographic technologies such as high-speed counter-current chromatography for the isolation and purification of Oridonin from Isodon rubescens.     HPLC Verification Following purification, analytical testing is used to determine whether the material meets the required specification. HPLC can provide information about: Retention time   Target peak Relative purity Chromatographic profile Potential impurities Research has also developed HPLC-based methods for simultaneous characterization and quantification of multiple compounds in Rabdosia rubescens, highlighting the importance of chromatographic analysis in quality control.     CQHERB Technical Insight For high-purity botanical monomers, the manufacturing challenge is not simply "extracting more compound." The key challenge is achieving selective purification while maintaining reproducible analytical quality. This is why a professional supplier should be able to explain not only the final purity but also the analytical method used to verify that specification.     7. Oridonin Quality Standards and HPLC Analysis Is 98% Purity Enough? Not necessarily. A 98% purity statement is useful, but it should be interpreted together with the analytical method and supporting documentation. When evaluating an Oridonin 98% material, buyers should review: 1. HPLC Purity Confirm how the 98% value was determined. Questions may include: Which HPLC method was used? Is the method clearly described? Is the chromatogram available? Is the purity calculated by area normalization or another method? 2. Identity The supplier should be able to demonstrate that the tested compound is Oridonin rather than another diterpenoid with a similar chromatographic behavior. 3. Chromatographic Profile A chromatogram can provide useful information about: Main peak Retention time Secondary peaks Overall sample profile 4. Residual Solvents If organic solvents are used during manufacturing, residual solvent testing may be appropriate depending on the intended application and applicable standards. 5. Heavy Metals and Contaminants For botanical-derived materials, buyers may also request information concerning: Lead Cadmium Arsenic Mercury Microbiological parameters     Recommended Technical Documents For international B2B procurement, a professional supplier should be prepared to provide, where applicable: Certificate of Analysis (COA) Product Specification HPLC Chromatogram SDS / MSDS Technical Data Sheet Residual Solvent Information Heavy Metal Information Packaging Information Storage Recommendations     8. Oridonin Solubility and Stability Considerations Solubility is an important technical issue when working with Oridonin. Published research has identified relatively limited aqueous solubility and bioavailability as important challenges in the development of Oridonin-based pharmaceutical formulations. Researchers have investigated approaches including structural modification, formulation technologies, nanoparticles, liposomes, and co-crystals to address these limitations. For research and formulation developers, this means that Oridonin should not be evaluated only according to chemical purity. Practical considerations can include: Solvent selection Concentration Temperature Storage conditions Light exposure Container compatibility Formulation matrix     Why Solubility Matters in Research Two samples with identical HPLC purity can behave differently in a practical formulation if: Particle size differs Sample preparation differs Solvent systems differ Storage history differs Experimental temperature differs Therefore, research protocols should clearly document sample preparation conditions when Oridonin is used in solution-based experiments. Section Summary Oridonin's physicochemical characteristics, particularly its limited aqueous solubility, are important considerations for research and formulation development. High chemical purity does not automatically guarantee easy formulation or high bioavailability.     9. Research Applications of Oridonin Oridonin has been investigated across several areas of scientific research. Natural Product Chemistry Researchers study Oridonin as a representative ent-kaurane diterpenoid and as one component of the complex phytochemistry of Isodon rubescens. Research topics include: Isolation Structural elucidation Derivatization Analytical characterization Natural-product biosynthesis     Molecular and Cellular Research A large body of experimental literature has examined Oridonin in relation to cellular processes such as: Apoptosis Autophagy Cell-cycle regulation Oxidative stress Inflammatory signaling Cellular metabolism These findings are predominantly based on laboratory and preclinical models and should not be interpreted as proof of clinical efficacy. Recent reviews continue to examine Oridonin's proposed molecular mechanisms and its interaction with multiple signaling pathways.     Pharmaceutical Chemistry Research Oridonin has also become a useful starting scaffold for medicinal-chemistry research. Researchers have explored structural modifications designed to address challenges such as: Poor aqueous solubility Limited bioavailability Rapid clearance Pharmacokinetic limitations Oridonin derivatives have therefore become a separate research area within natural-product drug discovery.     Analytical Research Because Oridonin is a defined chemical compound, it can also be used in: HPLC method development LC-MS analysis Reference-material research Botanical quality-control studies Comparative phytochemical analysis   Important Research Disclaimer The biological activities described in scientific literature do not mean that Oridonin 98% sold as a research ingredient is an approved pharmaceutical or that it is intended to diagnose, treat, cure, or prevent disease. Research findings should always be interpreted according to the experimental model, concentration, formulation, and study design.     10. Oridonin Derivatives and Structural Modification One particularly interesting aspect of Oridonin research is the development of chemically modified derivatives. The natural Oridonin scaffold has been used as a starting point for exploring changes to functional groups and molecular regions that may affect: Solubility Stability Target interaction Pharmacokinetics Biological activity Reviews of Oridonin derivatives have documented extensive medicinal-chemistry research aimed at improving properties of the parent compound. This research demonstrates an important principle in natural-product chemistry: A natural compound can serve not only as a research material itself, but also as a structural template for the development of new chemical entities. Section Summary Oridonin continues to attract interest as both a natural compound and a chemical scaffold. Research on its derivatives illustrates the intersection between botanical chemistry, medicinal chemistry, and modern drug-discovery research.     11. How to Choose a Reliable Oridonin Supplier For B2B buyers, selecting an Oridonin supplier should involve more than comparing prices. 1. Confirm Product Identity Check: CAS number Chemical name Molecular formula Molecular weight HPLC profile 2. Confirm Purity Method Ask how the 98% specification is determined and request the corresponding analytical documentation. 3. Review Batch Documentation A current-batch COA is more useful than a generic specification sheet. 4. Evaluate Manufacturing Capability Understand whether the supplier: Manufactures the material Controls purification Performs analytical testing Maintains batch records 5. Evaluate Technical Support For research-grade ingredients, technical communication can be as important as price. A reliable supplier should be able to answer questions about Purity HPLC Solubility Storage Packaging Lead time Documentation     12. Buyer Checklist for Oridonin 98% Before placing an order, buyers can use the following checklist. Confirm CAS 28957-04-2 Confirm molecular formula C20H28O6 Confirm molecular weight Confirm ≥98% HPLC specification Request current-batch COA Request HPLC chromatogram Confirm identity-testing method Review residual solvent information Review heavy-metal information Confirm packaging Confirm storage conditions Confirm sample availability Confirm production lead time Confirm technical documentation Evaluate long-term supply capability     13. Frequently Asked Questions What is Oridonin? Oridonin is a naturally occurring ent-kaurane diterpenoid primarily associated with Isodon rubescens. Its CAS number is 28957-04-2. What is the CAS number of Oridonin? The commonly recognized CAS number is 28957-04-2. What is the molecular formula of Oridonin? The molecular formula is C20H28O6. What is the molecular weight of Oridonin? The molecular weight is approximately 364.4 g/mol. What plant does Oridonin come from? Oridonin is primarily associated with Isodon rubescens, a species in the Lamiaceae family. Rabdosia rubescens is a recognized synonym. Is Oridonin the same as Dong Ling Cao extract? No. Dong Ling Cao or Isodon rubescens extract is a complex botanical preparation, while Oridonin is a purified individual compound. What does 98% Oridonin mean? It generally indicates that Oridonin constitutes at least approximately 98% of the material according to the stated analytical method, commonly HPLC. The analytical method should always be reviewed alongside the stated purity. How is Oridonin purity tested? HPLC is commonly used for quantitative analysis and purity assessment. Additional techniques such as LC-MS or NMR can be used for identity characterization depending on the application. Is Oridonin water soluble? Oridonin has limited aqueous solubility, which has been identified as an important technical challenge in pharmaceutical formulation research. What is Oridonin used for? High-purity Oridonin is primarily relevant to scientific research, natural-product chemistry, analytical studies, pharmaceutical chemistry, and formulation-development research. Is Oridonin an approved drug? Research into Oridonin and Oridonin derivatives is ongoing, but a research-grade Oridonin ingredient should not be represented as an approved pharmaceutical merely because pharmacological studies have been published. What is the difference between Oridonin and other Isodon diterpenoids? Isodon rubescens contains numerous diterpenoids. Oridonin is one specific compound with its own chemical identity, molecular formula, and analytical profile. Can Oridonin be used as an analytical reference material? High-purity Oridonin can be relevant to analytical research, but suitability as a formal reference standard depends on the required certification, purity characterization, intended analytical method, and applicable standards. Why is HPLC important for Oridonin? HPLC provides a practical way to separate and quantify Oridonin and assess the chromatographic profile of a sample. What documents should an Oridonin supplier provide? Typical documents may include COA, specification sheet, HPLC chromatogram, SDS/MSDS, and technical data. Additional documents depend on the customer's application and regulatory requirements. How should Oridonin be stored? Storage recommendations should follow the supplier's validated specification and stability information. In general, minimizing unnecessary exposure to heat, moisture, and light is a prudent approach for purified natural products. Can Oridonin derivatives be synthesized? Yes. Numerous research programs have investigated structural modification of Oridonin to explore changes in physicochemical and biological properties. Why do researchers study Oridonin derivatives? One major reason is to investigate whether structural modification can address limitations of the parent compound, including solubility and pharmacokinetic characteristics. What should buyers check before purchasing Oridonin 98%? The most important items include identity, HPLC purity, chromatogram, COA, production source, analytical method, contaminants, storage conditions, and supplier consistency. Is Oridonin 98% the same as a 98% Isodon rubescens extract? No. "98% Oridonin" describes a purified compound specification, whereas "98% Isodon rubescens extract" would describe a very different product concept and should not be assumed to have the same chemical composition.     14. CQHERB Technical Insight Purity Is Only One Part of Botanical Monomer Quality For high-purity botanical compounds such as Oridonin, it is tempting to evaluate suppliers based solely on the number printed on the COA. However, professional procurement requires a broader view. A robust quality assessment should consider: Identity Is the material actually Oridonin? Purity Does the material meet the stated ≥98% specification? Analytical Method How was the purity determined? Chromatographic Profile Does the HPLC chromatogram demonstrate a clean and consistent profile? Contaminant Control Are residual solvents, heavy metals, moisture, and microbiological parameters appropriately controlled? Batch Consistency Can the supplier provide the same specification repeatedly? Traceability Can the material be traced to a defined manufacturing and testing process? This approach is particularly important when Oridonin is used in research projects where reproducibility is more important than simply achieving the lowest purchase price.     15. Industry Insight The development of Oridonin reflects a broader trend in the botanical ingredient industry: the transition from complex traditional extracts toward well-characterized natural compounds. Researchers and manufacturers increasingly require: Defined molecular identity Standardized purity Reliable analytical data Consistent batch quality Transparent technical documentation At the same time, advances in natural-product chemistry are creating new opportunities for studying botanical compounds as molecular scaffolds rather than simply as traditional herbal extracts. Oridonin is a particularly useful example of this transition because research has expanded from simple isolation and characterization to molecular mechanisms, pharmacokinetics, structural modification, delivery technologies, and derivative development.     Why We Published This Guide The purpose of this guide is not to promote Oridonin through unsupported efficacy claims. Instead, CQHERB aims to provide researchers, manufacturers, and purchasing professionals with a practical technical reference for understanding: What Oridonin is Where it comes from How it differs from botanical extracts How high-purity material is evaluated Why HPLC matters What technical challenges researchers should consider How to evaluate suppliers For botanical ingredients, reliable information is an essential part of product quality.     Final Summary Oridonin is a structurally distinctive ent-kaurane diterpenoid primarily associated with Isodon rubescens. With a molecular formula of C20H28O6 and CAS 28957-04-2, it has become one of the most extensively studied diterpenoids from this botanical source. Modern research extends from natural-product isolation and structural characterization to molecular biology, pharmacokinetics, formulation science, and the development of Oridonin derivatives. At the same time, researchers continue to investigate challenges such as limited aqueous solubility and bioavailability. For B2B buyers, the key consideration is that 98% Oridonin is a purified single compound rather than a conventional Isodon rubescens extract. Its quality should therefore be evaluated through a combination of purity, identity, HPLC profile, contaminant control, documentation, and batch consistency. As scientific interest in standardized natural compounds continues to expand, Oridonin represents an important example of how traditional botanical resources can become well-characterized materials for modern natural-product and pharmaceutical research.     Looking for a Reliable Oridonin Supplier? If you are sourcing high-purity Oridonin (98%) for research, analytical development, formulation studies, or long-term B2B supply, technical specifications should be evaluated according to your intended application. CQHERB can provide product information and technical documentation for evaluation, including: COA Product Specification HPLC Chromatogram SDS/MSDS Technical Data Sample Support Packaging Information Request Technical Information     Scientific References PubChem. Oridonin – CID 5321010. National Center for Biotechnology Information. Royal Botanic Gardens, Kew. Plants of the World Online: Isodon rubescens (Hemsl.) H.Hara. Royal Botanic Gardens, Kew. Rabdosia rubescens (Hemsl.) H.Hara – synonym of Isodon rubescens. Ali MA, et al. Oridonin from Rabdosia rubescens: An emerging potential in cancer therapy – A comprehensive review. Food Science & Nutrition. 2024. Zhang Y, Wang S, Dai M, et al. Solubility and Bioavailability Enhancement of Oridonin: A Review. Molecules. 2020;25(2):332. Oridonin: A Review of Its Pharmacology, Pharmacokinetics and Toxicity. PubMed-indexed review. Sobral PJM, Vicente ATS, Salvador JAR. Recent advances in oridonin derivatives with anticancer activity. Frontiers in Chemistry. 2023. The Natural Product Oridonin as an Anticancer Agent: Current Achievements and Problems. PubMed-indexed review. 2023. Isolation and Purification of Oridonin from the Whole Plant of Isodon rubescens by High-Speed Counter-Current Chromatography. Simultaneous characterization and quantification of 17 main compounds in Rabdosia rubescens by high performance liquid chromatography. PubMed. Recent Advances on the Molecular Mechanisms of Apoptosis Induced by Natural Product Oridonin and Its Derivatives. 2026 review. Anticancer mechanisms on pyroptosis induced by Oridonin: New potential targeted therapeutic strategies. Biomedicine & Pharmacotherapy. 2023.   The bioavailability enhancement and insight into the action mechanism of poorly soluble natural compounds from co-crystals preparation: Oridonin as an example. Phytomedicine. 2024. Discovery and development of natural product oridonin-inspired anticancer agents. PubMed-indexed review. Research progress and molecular mechanism of oridonin in the treatment of malignant melanoma. 2025 review.     Content Classification Content Type: Ultimate Guide / Pillar PageKnowledge Base Category: Botanical Extract Knowledge BasePrimary Search Intent: Informational + Commercial InvestigationTarget Audience: Researchers, formulators, manufacturers, procurement professionals and ingredient buyersRecommended Content Cluster: Oridonin Ultimate Guide↓What Is Oridonin?↓Oridonin Chemical Structure↓Oridonin Solubility & Stability↓Oridonin HPLC & COA Guide↓Oridonin Extraction & Purification↓Oridonin vs. Isodon rubescens Extract↓How to Choose an Oridonin Supplier↓Oridonin FAQ Hub     Important Editorial Note This article intentionally distinguishes scientific research findings from established clinical or commercial claims. Oridonin has been extensively investigated in experimental systems, but published preclinical findings should not be presented as proof of human therapeutic efficacy. This positioning helps maintain the professional, research-oriented character of the CQHERB Knowledge Base and reduces unnecessary regulatory and advertising risk.

Cyclopamine is a naturally occurring steroidal alkaloid associated with the plant *Veratrum californicum*, commonly known as corn lily or California false hellebore. It has attracted considerable attention in biochemical and cell-signaling research because of its interaction with the Hedgehog (Hh) signaling pathway.   For researchers and technical buyers, cyclopamine is primarily relevant as a research compound and molecular tool for investigating Hedgehog signaling, Smoothened (SMO), and related cellular processes.   This guide provides an overview of cyclopamine's chemical identity, botanical origin, research background, mechanism of action in the Hedgehog pathway, analytical considerations, and procurement considerations for laboratory research.   Research-use notice: Cyclopamine is discussed here as a research compound. The information on this page is provided for scientific and educational purposes and is not intended to describe cyclopamine as a pharmaceutical product or to recommend its use for the diagnosis, prevention, or treatment of any disease.   Quick Answer   Cyclopamine is a naturally occurring steroidal alkaloid associated with *Veratrum californicum*. Its CAS number is **4449-51-8**, and its molecular formula is **C27H41NO2**, with a molecular weight of approximately 411.6 g/mol.   In biochemical research, cyclopamine is best known as a small-molecule modulator of the **Hedgehog signaling pathway**, particularly through interaction with **Smoothened (SMO)**.   Because of its historical botanical origin and well-established role in Hedgehog pathway research, cyclopamine is frequently used as a reference compound in studies involving cellular signaling, developmental biology, molecular pharmacology, and compound screening.   Cyclopamine Chemical Information The basic chemical information for cyclopamine is summarized below.   | Property                             | Information                                         | | ------------------------------------ | --------------------------------------------------- | | Product Name                         | Cyclopamine                                         | | CAS Number                           | 4449-51-8                                           | | Alternative Name                     | 11-Deoxojervine                                     | | Molecular Formula                    | C27H41NO2                                           | | Molecular Weight                     | 411.6 g/mol                                         | | Chemical Class                       | Steroidal alkaloid                                  | | Natural Source                       | *Veratrum* species                                  | | Commonly Associated Botanical Source | *Veratrum californicum*                             | | Research Area                        | Hedgehog signaling and related biochemical research | | Typical Research Form                | Solid / powder reference material                   |   According to PubChem, cyclopamine is also known by the synonym 11-deoxojervine and is classified as a steroidal alkaloid. PubChem records cyclopamine in several *Veratrum* species, including *Veratrum californicum*.   For procurement and analytical documentation, the CAS number **4449-51-8** is particularly important because it helps distinguish cyclopamine from other structurally related *Veratrum* alkaloids.   What Is the Botanical Source of Cyclopamine?   Cyclopamine is closely associated with *Veratrum californicum*, a plant commonly referred to as corn lily or California false hellebore.   *Veratrum californicum* is native to mountainous regions of western North America. The plant contains a group of structurally related steroidal alkaloids, including cyclopamine and other *Veratrum* alkaloids.   Research on *Veratrum californicum* has shown that the alkaloid composition can vary according to plant part, collection location, and growth stage. Modern analytical studies have identified cyclopamine together with other steroidal alkaloids in the plant.   This botanical variability is important when discussing plant extracts versus isolated compounds.   A **cyclopamine reference compound is not equivalent to a whole *Veratrum* extract**.   A botanical extract may contain multiple alkaloids and other plant constituents, while purified cyclopamine represents a defined chemical component. Research comparing *Veratrum californicum* extracts with individual alkaloids has demonstrated that different alkaloid combinations can produce different experimental effects in Hedgehog pathway assays.   Cyclopamine and the Hedgehog Signaling Pathway   One of the most important reasons cyclopamine is studied is its relationship with the Hedgehog signaling pathway.   The Hedgehog pathway is a conserved cellular signaling system involved in developmental and differentiation processes. In mammals, the pathway involves several key components, including:   * Hedgehog ligands * Patched (PTCH) receptors * Smoothened (SMO) * Suppressor of Fused (SUFU) * GLI transcription factors   When Hedgehog signaling is activated, changes in SMO activity influence downstream signaling events involving GLI transcription factors.   Cyclopamine became an important molecular research tool because it can interfere with Hedgehog pathway signaling at the level of Smoothened. Scientific literature describes cyclopamine as an antagonist of SMO and an inhibitor of Hedgehog pathway signaling.   This makes cyclopamine useful for laboratory studies designed to investigate the biological consequences of modulating Hedgehog signaling.   How Does Cyclopamine Interact With Smoothened?   Smoothened, commonly abbreviated as **SMO**, is a seven-transmembrane protein that plays a central role in Hedgehog signal transduction.   In simplified terms, Hedgehog signaling can be viewed as a regulatory sequence:   **Hedgehog ligand → PTCH → SMO → GLI → downstream gene expression**   Cyclopamine acts at the SMO stage of this signaling system.   Experimental studies have provided evidence that cyclopamine interacts with Smoothened and interferes with its signaling activity. This observation was important in establishing the relationship between cyclopamine and the Hedgehog pathway.   Because of this mechanism, cyclopamine is commonly included in experimental systems investigating:   * Hedgehog pathway activation * Smoothened signaling * GLI-dependent transcription * Cellular differentiation * Developmental signaling * Small-molecule pathway modulation * Mechanistic studies of Hedgehog-related biology   Importantly, these research applications should not be interpreted as an indication that cyclopamine is an approved therapeutic product.   Why Is Cyclopamine Important in Research?   Cyclopamine has a distinctive place in the history of Hedgehog signaling research.   Its botanical history preceded the discovery of its molecular mechanism. Research into abnormal developmental outcomes associated with ingestion of *Veratrum californicum* eventually led to the identification of cyclopamine as an active steroidal alkaloid. Decades later, studies established its connection with Hedgehog signaling.   This historical sequence made cyclopamine an important example of how a naturally occurring plant compound can contribute to the discovery and characterization of a cellular signaling pathway.   Today, cyclopamine continues to appear in scientific literature as a reference compound for studies involving Hedgehog pathway modulation.   A recent review of *Veratrum californicum* alkaloids also describes cyclopamine as the best-studied alkaloid from the plant in the context of Hedgehog signaling research.   Cyclopamine vs. *Veratrum californicum* Extract   One of the most common points of confusion is the difference between cyclopamine and *Veratrum californicum* extract.   | Feature            | Cyclopamine                                     | *Veratrum californicum* Extract                         | | ------------------ | ----------------------------------------------- | ------------------------------------------------------- | | Material Type      | Defined chemical compound                       | Botanical extract                                       | | Composition        | Primarily cyclopamine as the specified compound | Multiple naturally occurring constituents               | | CAS                | 4449-51-8                                       | Depends on extract specification                        | | Chemical Identity  | Defined                                         | Complex mixture                                         | | Research Use       | Molecular and biochemical research              | Botanical and phytochemical research                    | | Analytical Control | Can be specified by chemical purity             | Requires extract-specific marker or fingerprint testing | | Interchangeable?   | No                                              | No                                                      |   A whole-plant extract should therefore not be represented simply as “cyclopamine.”   The distinction is especially important for technical documentation, specifications, COAs, customs documents, and research applications.   Cyclopamine and Related *Veratrum* Alkaloids   *Veratrum* plants contain a range of steroidal alkaloids. Cyclopamine is only one member of this chemically diverse group.   Other compounds reported in *Veratrum californicum* research include:   * Veratramine * Muldamine * Isorubijervine * Jervine * Other structurally related steroidal alkaloids   Modern analytical studies have demonstrated substantial variation in alkaloid composition depending on plant material and extraction conditions.   For researchers working with purified cyclopamine, this distinction is useful because biological results obtained from a complex botanical extract cannot automatically be attributed to cyclopamine alone.   ## Analytical Identification of Cyclopamine   For research-grade cyclopamine, analytical characterization is an important part of quality control.   Common analytical approaches may include:   HPLC   High-performance liquid chromatography can be used to evaluate chromatographic purity and to monitor the presence of related components.   For a commercial research material, the analytical specification should clearly identify:   * Target compound * CAS number * Purity method * Analytical result * Batch number * Test date * Reference standard or analytical method where applicable   LC-MS   Liquid chromatography coupled with mass spectrometry can provide additional confirmation of molecular identity and help distinguish cyclopamine from structurally related *Veratrum* alkaloids.   Structural Information   PubChem lists cyclopamine under CAS 4449-51-8, molecular formula C27H41NO2, and molecular weight 411.6 g/mol.   For B2B research-material procurement, identity information should be consistent across the product specification, COA, SDS, label, and shipping documentation.   Factors to Consider When Purchasing Cyclopamine for Research   Researchers and purchasing teams should evaluate more than the stated purity percentage when sourcing cyclopamine.   1. Confirm the Chemical Identity   The CAS number should be clearly stated as:   **Cyclopamine — CAS 4449-51-8**   Alternative names such as 11-deoxojervine may also appear in scientific databases and literature.   2. Review the Analytical Specification   The supplier should be able to provide appropriate analytical documentation, such as:   * COA * HPLC chromatogram where available * Product specification * SDS * Batch information * Appearance * Purity result   3. Distinguish Purified Cyclopamine From Botanical Extract   If the project requires a defined compound, a whole *Veratrum* extract should not automatically be considered an equivalent material.   4. Consider Packaging   Cyclopamine should be handled and packaged according to the supplier's applicable chemical handling and storage specifications.   For international shipments, packaging should also be compatible with the requirements of the selected courier and destination country.   5. Check Documentation Before Shipment   International research-material shipments may require additional documentation depending on the destination, transport method, and local requirements.   Potential documentation can include:   * Commercial invoice * Packing list * SDS * COA * Product specification * Customs information * Transport-related documents where applicable   Buyers should confirm local import requirements before placing an international order.   Cyclopamine Storage and Handling   Cyclopamine is a research chemical and should be handled by appropriately trained personnel according to the supplier's SDS and laboratory procedures.   Storage conditions should follow the manufacturer's product specification and SDS rather than relying on generic recommendations.   For long-term storage, laboratories should also consider:   * Temperature control * Moisture exposure * Light exposure * Container integrity * Repeated opening and closing * Batch traceability   The appropriate storage conditions may depend on the specific product specification, formulation, packaging configuration, and intended research workflow.   Is Cyclopamine a Pharmaceutical Product?   Cyclopamine should not be presented as an approved pharmaceutical product on a commercial research-material website.   Its importance in the scientific literature is primarily related to its role as a research compound and Hedgehog pathway modulator.   Although scientific studies have investigated cyclopamine and related compounds in various biological models, research findings should not be converted into claims that a commercial cyclopamine product can diagnose, prevent, or treat a disease.   This distinction is particularly important for international websites and digital advertising.   Google Ads' current Healthcare and Medicines policy restricts promotion of certain unapproved substances and prohibits marketing that implies an unapproved product is safe or effective for preventing, curing, or treating a disease.   Research Areas Associated With Cyclopamine   Because of its interaction with Smoothened and Hedgehog signaling, cyclopamine appears in research involving several scientific fields.   Cell Signaling Research   Cyclopamine can be used as a chemical tool for investigating changes associated with Hedgehog pathway modulation.   Developmental Biology   The Hedgehog pathway has important roles in developmental biology, making cyclopamine relevant to experimental studies of pathway function.   Molecular Pharmacology   Cyclopamine has historically been used to investigate Smoothened and the molecular pharmacology of Hedgehog signaling.   Drug Discovery Research   Cyclopamine has also served as a reference structure in research exploring small-molecule Hedgehog pathway modulators and related chemical scaffolds.   These descriptions refer to research contexts and should not be interpreted as commercial therapeutic claims.   Cyclopamine and Modern Hedgehog Pathway Research   Cyclopamine was one of the earliest small molecules identified as capable of interfering with Hedgehog signaling.   Subsequent research led to the development and investigation of additional Smoothened-targeting compounds and other Hedgehog pathway modulators.   Scientific reviews describe cyclopamine as an important historical tool for understanding SMO and Hedgehog signaling, while also noting limitations that affected its development as a therapeutic candidate.   For current laboratory research, cyclopamine therefore has particular value as a **mechanistic research compound**, rather than as a commercial therapeutic ingredient.   Why Researchers Specify CAS 4449-51-8   CAS numbers are particularly useful when ordering specialized research compounds.   The name “cyclopamine” may appear together with alternative names such as:   * Cyclopamine * 11-Deoxojervine * 11-Deoxyjervine   Using the CAS number **4449-51-8** alongside the product name can reduce ambiguity during:   * Supplier communication * Purchase orders * COA review * SDS preparation * Customs documentation * Laboratory inventory management * Analytical database searches   PubChem currently identifies 4449-51-8 as the CAS number for cyclopamine and lists 11-deoxojervine among its synonyms.   CQ HERB Cyclopamine Research Material   CQ HERB provides botanical-derived research compounds and plant extract materials for B2B customers, with technical documentation available according to the specific product specification.   For cyclopamine-related inquiries, customers can discuss: * Required purity * Research quantity * Packaging * COA requirements * SDS requirements * Analytical documentation * Shipping destination * Documentation required for international shipment   For technical purchasing, we recommend confirming the exact specification before placing an order, particularly when the project requires a defined purity level or analytical method.   Frequently Asked Questions What is cyclopamine? Cyclopamine is a naturally occurring steroidal alkaloid associated with *Veratrum californicum*. It is widely discussed in scientific literature because of its interaction with the Hedgehog signaling pathway.   What is the CAS number of cyclopamine? The CAS number of cyclopamine is **4449-51-8**.   What is the molecular formula of cyclopamine?   The molecular formula is **C27H41NO2**, and PubChem lists a molecular weight of approximately **411.6 g/mol**.   What plant does cyclopamine come from? Cyclopamine is particularly associated with *Veratrum californicum*, commonly known as corn lily or California false hellebore. It has also been reported in other *Veratrum* species.   Is cyclopamine the same as *Veratrum californicum* extract? No. Cyclopamine is a defined chemical compound, whereas *Veratrum californicum* extract is a complex botanical mixture that may contain multiple steroidal alkaloids.   What is cyclopamine used for in research? Cyclopamine is primarily used as a research compound for studying Hedgehog signaling, Smoothened, and related cellular and molecular processes.   Is cyclopamine an approved medicine? Cyclopamine should not be represented on a commercial research-material website as an approved pharmaceutical product. Its primary relevance in this context is as a research compound.   Can cyclopamine be used in human or animal applications?   Any use involving humans or animals should be evaluated under the applicable institutional, regulatory, ethical, and safety requirements. This product page is intended for research and informational purposes and does not provide clinical or veterinary use recommendations.   How should cyclopamine be stored?   Storage should follow the specific supplier's SDS and product specification. Laboratories should maintain appropriate control of temperature, moisture, light exposure, and container integrity.   Key Takeaways * Cyclopamine is a naturally occurring steroidal alkaloid. * Its CAS number is **4449-51-8**. * Its molecular formula is **C27H41NO2**. * It is closely associated with *Veratrum californicum*. * Cyclopamine is widely recognized in scientific literature as a Hedgehog pathway research compound. * Its best-characterized molecular research target is Smoothened (SMO). * Purified cyclopamine should not be confused with whole-plant *Veratrum* extracts. * Research findings should not be presented as evidence of clinical efficacy or as a therapeutic recommendation. * Buyers should confirm identity, purity, analytical documentation, SDS, packaging, and shipping requirements before procurement.   References 1. PubChem. Cyclopamine, CID 442972. National Center for Biotechnology Information. 2. Pharmacology of *Veratrum californicum* Alkaloids as Hedgehog Pathway Antagonists. 3. Cyclopamine Bioactivity by Extraction Method from *Veratrum californicum*. 4. Hedgehog pathway as a drug target: Smoothened inhibitors in development. 5. Native *V. californicum* Alkaloid Combinations Induce Differential Inhibition of Sonic Hedgehog Signaling. 6. I only have eye for ewe: the discovery of cyclopamine and development of Hedgehog pathway-targeting drugs.   Disclaimer The information provided in this article is intended for scientific, educational, and research-reference purposes only. Cyclopamine is presented as a research compound and chemical reference material. Nothing on this page should be interpreted as medical advice, a therapeutic recommendation, or a claim that cyclopamine can diagnose, prevent, or treat any disease.   Users and purchasers are responsible for ensuring that their intended use, handling, storage, importation, and application of cyclopamine comply with applicable laws, regulations, institutional requirements, and safety procedures.

Cycloastragenol Ultimate Guide (2026) Everything You Need to Know About Cycloastragenol (CAG): Benefits, Manufacturing, Specifications, Applications & Buying Guide Author: CQHERB Technical Team Last Updated: July 2026 Estimated Reading Time: 18 Minutes What Is Cycloastragenol? Cycloastragenol (CAG) is a naturally occurring cycloartane-type triterpenoid aglycone derived from Astragalus membranaceus. It is most commonly obtained through the controlled hydrolysis or biotransformation of Astragaloside IV, one of the major bioactive saponins found in Astragalus root. Due to its extremely low natural abundance, commercial-scale Cycloastragenol is rarely produced through direct extraction. Instead, modern manufacturing relies on carefully controlled conversion technologies to achieve high purity and batch consistency. Today, Cycloastragenol has become one of the most extensively researched compounds from Astragalus species, attracting attention in healthy aging research, nutraceutical development, cosmetic ingredient innovation, and natural product science. Quick Answer Cycloastragenol is a high-value triterpenoid compound derived from Astragalus species. Commercial products are typically manufactured by converting Astragaloside IV into Cycloastragenol through hydrolysis or biotransformation processes. High-purity Cycloastragenol (≥98% HPLC) is widely used for dietary supplement formulation, cosmetic ingredient development, and scientific research. Key Takeaways Cycloastragenol is a rare aglycone naturally derived from Astragalus species. Commercial production primarily relies on Astragaloside IV conversion rather than direct extraction. High-purity material (≥98% HPLC) is preferred for research and premium formulations. Manufacturing technology plays a critical role in purity, impurity profile, and production cost. Professional suppliers should provide comprehensive quality documentation, including COA, SDS, TDS, and HPLC chromatograms. Table of Contents What Is Cycloastragenol? Chemical Properties Natural Sources Manufacturing Process Cycloastragenol vs Astragaloside IV Scientific Research Interest Potential Applications CQHERB Product Specifications Quality Control How to Choose a Reliable Supplier Frequently Asked Questions Chemical Properties Property Value Product Name Cycloastragenol CAS No. 84605-18-5 Molecular Formula C30H50O5 Molecular Weight 490.72 Appearance White to Off-white Powder Test Method HPLC Standard Purity ≥98% HPLC Cycloastragenol belongs to the cycloartane triterpenoid family. Unlike Astragaloside IV, it does not contain sugar moieties, resulting in different physicochemical characteristics and formulation properties. Natural Sources of Cycloastragenol Cycloastragenol naturally occurs in several Astragalus species, including: Astragalus membranaceus Astragalus mongholicus Although naturally present, its concentration in the plant is extremely low. Direct extraction is therefore not considered commercially practical for large-scale production. Most high-purity Cycloastragenol available on the global market is produced through controlled conversion from Astragaloside IV. How Is Cycloastragenol Manufactured? Commercial Cycloastragenol production generally involves multiple controlled manufacturing steps to ensure purity and consistency. Step 1. Extraction of Astragalus Root Selected Astragalus roots are extracted to obtain crude saponins containing Astragaloside IV. Step 2. Purification of Astragaloside IV The extract undergoes multiple purification procedures to isolate high-purity Astragaloside IV. Step 3. Hydrolysis or Biotransformation Astragaloside IV is converted into Cycloastragenol using optimized hydrolysis or biotransformation technologies. Step 4. Purification The reaction product is purified through chromatographic separation and crystallization to remove impurities. Step 5. Quality Testing Each production batch is analyzed using HPLC and additional quality control methods before packaging. Typical Manufacturing Flow Astragalus Root ↓ Extraction ↓ Astragaloside IV ↓ Hydrolysis / Biotransformation ↓ Purification ↓ Crystallization ↓ Cycloastragenol ↓ HPLC Quality Control ↓ Packaging Cycloastragenol vs Astragaloside IV Feature Cycloastragenol Astragaloside IV Compound Type Aglycone Glycoside Sugar Groups No Yes Molecular Weight Lower Higher Manufacturing Conversion Product Direct Plant Component Market Value Higher Lower Purification Difficulty High Moderate Although closely related, Cycloastragenol and Astragaloside IV are chemically distinct compounds with different production processes and application characteristics. Why Has Cycloastragenol Attracted Scientific Interest? Over the past decade, Cycloastragenol has become an active topic in natural product and healthy aging research. Published studies have investigated its potential role in: Telomerase-related research Cellular senescence studies Oxidative stress models Immune system research Healthy aging research Skin biology studies Cellular metabolism It is important to note that much of the available evidence comes from laboratory and preclinical research. Product applications should always comply with local regulatory requirements. Potential Applications Dietary Supplements Cycloastragenol is commonly formulated into: Capsules Tablets Powder blends Softgels Functional nutrition products Cosmetic Ingredients Because of its botanical origin and ongoing scientific interest, Cycloastragenol has also attracted attention for cosmetic ingredient development, including: Anti-aging serums Facial creams Premium skincare products Eye care formulations Application suitability should be evaluated according to formulation requirements and local cosmetic regulations. CQHERB Cycloastragenol Specifications Item Specification Botanical Source Astragalus membranaceus Root Appearance White Powder Assay ≥98% HPLC Identification HPLC Loss on Drying ≤2.0% Heavy Metals Complies with Internal Specification Residual Solvents Controlled According to Applicable Standards Storage Store in a Cool, Dry Place Shelf Life 24 Months Quality Control At CQHERB, each production batch undergoes comprehensive quality evaluation to ensure consistency and traceability. Typical quality control procedures include: HPLC Assay Identity Verification Heavy Metal Analysis Residual Solvent Testing Microbiological Testing (where applicable) Stability Evaluation Batch Traceability Supporting documentation may include: Certificate of Analysis (COA) Technical Data Sheet (TDS) Safety Data Sheet (SDS/MSDS) HPLC Chromatogram Production Flow Chart Buyer Checklist: How to Select a Reliable Cycloastragenol Supplier When sourcing Cycloastragenol, buyers should consider several important factors: Is the manufacturing route clearly described? Is the product tested by HPLC? Are chromatograms available? Is batch consistency maintained? Can the supplier provide COA, TDS, and SDS? Does the supplier have experience serving international B2B customers? Is technical support available for formulation and documentation? Selecting a supplier with transparent manufacturing processes and complete quality documentation can help reduce sourcing risks and support long-term product development. Why Choose CQHERB? CQHERB specializes in high-purity botanical active ingredients for the global nutraceutical, cosmetic, and pharmaceutical industries. Our strengths include: Professional botanical extract manufacturing Strict batch quality control HPLC-tested high-purity products Complete export documentation Technical support for international customers Stable production capacity for long-term supply Frequently Asked Questions Is Cycloastragenol naturally extracted? Cycloastragenol naturally occurs in Astragalus species; however, its concentration is extremely low. Most commercial products are manufactured by converting Astragaloside IV through controlled processing. What purity is commonly available? Research-grade Cycloastragenol is typically supplied at purity levels of 98% HPLC or higher. What is the difference between Cycloastragenol and Astragaloside IV? Astragaloside IV is a glycoside, while Cycloastragenol is its corresponding aglycone after sugar groups have been removed. They differ in chemical structure, production process, and formulation characteristics. Which industries use Cycloastragenol? Cycloastragenol is commonly supplied for nutraceutical development, cosmetic ingredient research, and natural product research. What quality documents should a supplier provide? Professional suppliers typically provide a Certificate of Analysis (COA), Technical Data Sheet (TDS), Safety Data Sheet (SDS/MSDS), HPLC chromatograms, and batch traceability documentation. Conclusion Cycloastragenol has become one of the most recognized high-value compounds derived from Astragalus membranaceus. As research into healthy aging, botanical bioactives, and advanced nutraceutical ingredients continues to evolve, demand for high-quality Cycloastragenol is expected to grow across global markets. For manufacturers and product developers, selecting a supplier with robust manufacturing capabilities, transparent quality control, and complete technical documentation is essential for ensuring product consistency and regulatory compliance.   CQHERB is committed to supplying high-purity Cycloastragenol with strict quality management, comprehensive technical support, and reliable global B2B service.

Part 3 Cordycepin Production, Quality Standards & Industrial Applications From Cultivation to High-Purity Cordycepin (98%) Quick Summary The production of high-purity Cordycepin requires a combination of biological cultivation technology, extraction expertise, purification processes, and rigorous analytical testing. Unlike simple botanical extracts, 98% Cordycepin represents a highly standardized single compound that requires precise control throughout the entire manufacturing process. For global buyers, evaluating Cordycepin quality involves more than checking purity percentage. A reliable assessment should include raw material traceability, production technology, analytical methods, HPLC chromatograms, COA documentation, residual solvent testing, and batch consistency. As demand for standardized natural compounds continues to grow, high-purity Cordycepin has become increasingly important across scientific research, biotechnology, nutraceutical development, functional ingredients, and other emerging applications. 6. How Is High-Purity Cordycepin (98%) Produced? Overview of Commercial Production Commercial Cordycepin production has evolved significantly from traditional fungal extraction methods toward more controlled and scalable manufacturing approaches. Today, high-purity Cordycepin is generally obtained from cultivated Cordyceps militaris through a combination of: Controlled cultivation Fermentation technology Extraction optimization Purification processes Analytical verification The goal of production is not only to achieve high purity but also to ensure: Consistent quality Reliable supply Batch reproducibility Traceable manufacturing records Main Production Process of Cordycepin 1. Strain Selection and Cultivation The production process begins with carefully selected Cordyceps militaris strains. Important factors include: Growth characteristics Cordycepin production capability Cultivation stability Microbial control Compared with wild fungal resources, cultivated strains provide better control over raw material quality and production consistency. 2. Cultivation and Fermentation Modern production may utilize controlled cultivation systems or fermentation technologies designed to optimize biomass growth and target compound production. Key parameters include: Temperature control Nutrient composition Fermentation conditions Cultivation time Environmental monitoring Controlled production conditions help improve reproducibility between different batches. 3. Extraction Process After cultivation, the biomass undergoes extraction to obtain Cordycepin-containing fractions. Extraction parameters may influence: Extraction efficiency Compound stability Impurity profile Downstream purification requirements A well-designed extraction process is essential for maintaining product quality. 4. Purification and Refinement Crude extracts contain multiple natural compounds. Therefore, additional purification steps are required to obtain high-purity Cordycepin. Typical purification stages include: Separation of unwanted components Concentration Purification Crystallization Drying The final objective is achieving a standardized Cordycepin product meeting the required purity specification. 5. Quality Testing and Release Before shipment, each batch should undergo analytical verification. Typical quality evaluation includes: Test Item Purpose HPLC Purity Determine Cordycepin content Identity Testing Confirm compound identity Appearance Visual quality evaluation Moisture Stability assessment Residual Solvents Safety evaluation Heavy Metals Contaminant control Microbiological Testing Quality assurance   CQHERB Technical Insight For high-purity botanical compounds, manufacturing capability is not determined only by extraction technology. A qualified supplier should have a complete quality management approach covering raw materials, production control, analytical verification, documentation, and customer technical support. For Cordycepin 98%, analytical transparency is especially important because purity alone does not fully describe product quality. Supporting documentation such as HPLC chromatograms, specifications, and batch records provides greater confidence for international buyers. 7. Understanding Cordycepin Quality Standards Why Is Purity Important? Purity is one of the most commonly evaluated parameters when purchasing Cordycepin. A product labeled as: Cordycepin 50% Cordycepin 90% Cordycepin 98% represents different levels of refinement and different application requirements. High-purity Cordycepin (98%) is typically selected when users require: Defined chemical composition Analytical consistency Research reproducibility Standardized formulation materials Key Quality Parameters for 98% Cordycepin 1. HPLC Purity High-Performance Liquid Chromatography (HPLC) is one of the most widely used methods for determining Cordycepin purity. A typical HPLC report provides: Retention time Peak identification Purity percentage Chromatographic profile For buyers, reviewing the HPLC chromatogram is an important step in supplier evaluation. 2. Identity Confirmation Identity testing ensures that the material supplied is truly Cordycepin. Common analytical approaches include: HPLC comparison LC-MS NMR analysis 3. Residual Solvent Testing Depending on the production process, residual solvent analysis may be required to verify compliance with applicable standards. 4. Heavy Metals and Microbiological Control Quality-focused suppliers should monitor: Lead Arsenic Mercury Cadmium as well as microbiological parameters when applicable. Buyer Checklist: How to Evaluate Cordycepin Quality Before purchasing, buyers should consider: ✅ Is HPLC purity clearly provided? ✅ Is a COA available? ✅ Is the manufacturing source transparent? ✅ Are analytical methods documented? ✅ Is batch consistency demonstrated? ✅ Are technical documents available? Recommended supplier documents: COA Specification Sheet HPLC Chromatogram MSDS/SDS Technical Data Sheet 8. Industrial Applications of High-Purity Cordycepin Research Applications Cordycepin is widely used as a research compound in areas including: Natural product chemistry Molecular biology Biotechnology research Analytical studies Because purified Cordycepin provides a defined chemical structure, it is valuable for laboratory studies requiring standardized materials. Nutraceutical Ingredient Development The growing consumer interest in mushroom-derived ingredients has increased demand for standardized Cordyceps-related compounds. Compared with general mushroom powders, purified Cordycepin offers manufacturers a more clearly defined ingredient profile. Applications may include: Ingredient research Formula development Standardization studies Functional Food Research Cordycepin is also studied within the broader field of functional food ingredients derived from natural sources. Manufacturers evaluating Cordycepin typically focus on: Ingredient identity Quality consistency Regulatory requirements Documentation support Cosmetic Ingredient Research Natural compounds derived from fungi and botanical sources have attracted increasing attention in cosmetic science. Cordycepin-related research continues to be explored within the broader natural ingredient research field. For cosmetic developers, important considerations include: Purity Stability Compatibility Safety documentation Industry Insight The market trend is moving from traditional mushroom extracts toward standardized natural compounds with clearly defined chemical identities. This shift creates increasing demand for ingredients such as: Cordycepin Cordyceps marker compounds Botanical monomers High-purity research materials Companies that can provide both product quality and technical documentation will have stronger advantages in the global ingredient supply chain. 9. How to Choose a Reliable Cordycepin Supplier? Choosing a supplier involves more than comparing prices. A professional evaluation should consider: Manufacturing Capability Reliable suppliers should understand: Raw material sourcing Extraction technology Purification processes Quality control procedures Documentation Support International buyers commonly require: COA Specification SDS Technical documents Analytical reports Quality Consistency A long-term supplier should demonstrate: Stable production Repeatable specifications Reliable communication Technical support CQHERB Buyer Tips When evaluating Cordycepin suppliers, buyers should focus on: 1. Product authenticity Confirm identity and purity through analytical documents. 2. Manufacturing transparency Understand whether the supplier controls production or only distributes products. 3. Technical support A professional supplier should be able to answer questions regarding: Production Testing Storage Documentation 4. Long-term cooperation ability Stable supply capability is especially important for commercial projects. Section Summary High-purity Cordycepin production requires a combination of cultivation expertise, purification technology, and rigorous quality control. For international buyers, selecting a reliable supplier involves evaluating not only purity but also analytical documentation, manufacturing capability, and long-term supply reliability. As the global market continues to move toward standardized botanical ingredients, Cordycepin represents an important example of how natural compounds can be transformed into high-quality industrial materials.

Understanding Cordycepin: Why It Has Become One of the Most Important Bioactive Compounds from Cordyceps militaris Quick Summary The growing interest in Cordycepin is driven not only by scientific research but also by advances in cultivation technology, fermentation processes, analytical methods, and the increasing demand for standardized botanical ingredients. Today, high-purity Cordycepin has become an important research material and industrial ingredient because it combines a well-defined molecular structure with reproducible quality and scalable production. 2. Why Has Cordycepin Become One of the Most Studied Natural Compounds? Over the past two decades, Cordycepin has evolved from a relatively specialized natural compound into one of the most recognized bioactive constituents derived from Cordyceps militaris. This transformation reflects broader developments in biotechnology, analytical chemistry, and the global botanical ingredients industry. Unlike many botanical extracts that consist of complex mixtures of naturally occurring compounds, Cordycepin can be isolated, purified, and characterized as a single molecule. This allows researchers and manufacturers to work with a material whose identity and purity can be consistently verified using established analytical methods such as High-Performance Liquid Chromatography (HPLC). As scientific interest in standardized botanical compounds continues to expand, Cordycepin has become increasingly important in natural product chemistry, biotechnology, formulation development, food science, cosmetic ingredient research, and laboratory applications. Rather than being driven by a single discovery, the growing attention surrounding Cordycepin is the result of several long-term trends that continue to shape the botanical extract industry. Four Key Factors Driving Global Interest 1. Advances in Cultivation and Fermentation Technology Modern cultivation systems for Cordyceps militaris have significantly improved production efficiency and consistency. Controlled fermentation environments enable manufacturers to obtain reliable raw materials while supporting scalable commercial production. 2. Demand for Standardized Botanical Ingredients Global manufacturers increasingly prefer ingredients with clearly defined specifications, traceable production processes, and comprehensive analytical documentation. High-purity Cordycepin aligns well with these expectations. 3. Progress in Analytical Technologies Analytical techniques such as HPLC, LC-MS, and NMR have made it possible to accurately identify, quantify, and verify Cordycepin. These tools support product standardization and improve confidence in quality evaluation. 4. Expanding Scientific Research Research involving Cordycepin now spans multiple scientific disciplines, contributing to a growing body of literature and increasing demand for high-quality research materials. Why Do Researchers Prefer High-Purity Cordycepin? For many scientific and industrial applications, consistency is just as important as purity. High-purity Cordycepin (typically ≥98% by HPLC) helps minimize variability between experiments and supports reliable analytical results. Researchers often prefer standardized materials because they provide: Clearly defined chemical identity High batch-to-batch consistency Improved analytical reproducibility Easier formulation development Better traceability throughout the supply chain Comprehensive technical documentation These characteristics make high-purity Cordycepin particularly suitable for laboratories, formulation scientists, and manufacturers requiring reproducible materials. Scientific Milestones in Cordycepin Development Period Development 1950s Initial identification of Cordycepin from fungi belonging to the Cordyceps genus 1980s–1990s Improvements in isolation and analytical characterization Early 2000s Expansion of cultivation techniques for Cordyceps militaris 2010s Advances in submerged fermentation and purification technologies Today Commercial availability of standardized high-purity Cordycepin for research and industrial applications This progression illustrates how advances in biotechnology and quality control have transformed Cordycepin into a widely recognized botanical ingredient. CQHERB Technical Insight From a manufacturing perspective, the commercial success of Cordycepin depends not only on its natural origin but also on the ability to produce it consistently. Controlled cultivation, optimized fermentation, and rigorous purification are essential for achieving high purity and reliable batch-to-batch quality. Comprehensive analytical testing—including HPLC purity, identity confirmation, residual solvents, heavy metals, and microbiological limits—provides a more complete evaluation than purity alone. Industry Insight The botanical ingredients industry is moving toward well-characterized compounds supported by transparent production processes and standardized specifications. Cordycepin reflects this broader trend, as manufacturers and researchers increasingly prioritize reproducibility, traceability, and technical documentation when selecting botanical ingredients. Section Summary The growing importance of Cordycepin is driven by advances in biotechnology, analytical science, and the demand for standardized botanical ingredients. Its defined molecular identity, scalable production, and reproducible quality have made it a valuable material for research and industrial development. 3. Understanding the Molecular Structure of Cordycepin What Makes Cordycepin Structurally Unique? Cordycepin, also known as 3'-Deoxyadenosine, belongs to the purine nucleoside family. It shares a close structural relationship with adenosine but differs in one important aspect: the hydroxyl (-OH) group at the 3' position of the ribose sugar is absent. Although this modification appears minor, it distinguishes Cordycepin as a unique naturally occurring nucleoside analog and forms the basis for its extensive investigation in natural product chemistry and molecular research. Basic Chemical Information Property Value Chemical Name Cordycepin Synonym 3'-Deoxyadenosine CAS Number 73-03-0 Molecular Formula C₁₀H₁₃N₅O₃ Molecular Weight 251.24 g/mol Appearance White to off-white crystalline powder Typical Commercial Purity ≥98% (HPLC) Cordycepin vs. Adenosine Feature Adenosine Cordycepin Chemical Family Purine nucleoside Purine nucleoside analog 3' Hydroxyl Group Present Absent Natural Occurrence Widely distributed in living organisms Primarily associated with Cordyceps militaris This comparison highlights the structural distinction that has made Cordycepin a focus of scientific investigation. Why Do Physicochemical Properties Matter? Understanding physicochemical properties is essential because they influence: Analytical testing Formulation compatibility Storage conditions Manufacturing consistency Product stability Quality control procedures Rather than serving only as technical specifications, these properties help manufacturers and researchers maintain consistent product performance throughout production and application. Key Definitions Cordycepin – A naturally occurring nucleoside analog (3'-Deoxyadenosine) primarily obtained from Cordyceps militaris. Nucleoside – A molecule consisting of a nitrogenous base linked to a sugar, serving as a fundamental component in many biological systems. HPLC – High-Performance Liquid Chromatography, an analytical technique widely used to verify identity and purity. Purity – The proportion of the target compound relative to total detectable components, commonly expressed as a percentage determined by validated analytical methods. Section Summary Cordycepin possesses a clearly defined molecular structure that distinguishes it from adenosine and supports accurate analytical characterization. These characteristics contribute to its value as a standardized botanical compound. 4. Where Does Commercial Cordycepin Come From? One of the most common misconceptions is that commercial Cordycepin is obtained directly from wild Cordyceps sinensis. In reality, the vast majority of high-purity Cordycepin available today is produced from cultivated Cordyceps militaris. Cultivated production offers significant advantages over wild resources, including greater sustainability, improved quality consistency, and better traceability throughout the manufacturing process. Why Is Cordyceps militaris the Preferred Source? Compared with wild fungal resources, cultivated Cordyceps militaris provides: Controlled cultivation conditions Stable raw material supply Better batch consistency Higher production efficiency Compatibility with industrial fermentation Sustainable resource utilization These advantages have made Cordyceps militaris the preferred commercial source for standardized Cordycepin production. From Mushroom to High-Purity Cordycepin Commercial production generally involves the following stages: Strain selection Controlled cultivation or submerged fermentation Biomass harvesting Extraction Purification Chromatographic separation Crystallization HPLC quality verification Packaging Each stage contributes to the production of a standardized ingredient with defined specifications and reproducible quality. CQHERB Technical Insight A reliable Cordycepin supplier should be able to provide not only a high-purity product but also comprehensive technical documentation, including COA, HPLC chromatograms, specifications, residual solvent information, and other quality records that support traceability and batch consistency. Section Summary   Modern commercial Cordycepin is primarily produced from cultivated Cordyceps militaris using controlled cultivation, purification, and analytical verification. This production approach supports sustainability, standardized quality, and reliable supply for research and industrial applications.

Cordycepin (98%) Ultimate Guide Production • Quality Standards • Scientific Research • Industry Applications • Supplier Selection Building Reliable Knowledge for Researchers, Manufacturers, and Global Buyers Cordycepin (3'-Deoxyadenosine) is one of the most extensively studied bioactive compounds naturally found in Cordyceps militaris. With increasing interest from the nutraceutical, functional food, cosmetic, and scientific research sectors, high-purity Cordycepin has become an important ingredient for laboratories and manufacturers seeking standardized, well-characterized botanical compounds. This guide summarizes current scientific knowledge and industry practices surrounding 98% Cordycepin, including its natural sources, production technologies, physicochemical characteristics, quality evaluation, and purchasing considerations. CTA Looking for a reliable manufacturer of high-purity Cordycepin? Request Technical Documents COA | Specification | HPLC Chromatogram | MSDS | Sample Availability Quick Answer What Is Cordycepin? Cordycepin (CAS No. 73-03-0), also known as 3'-Deoxyadenosine, is a naturally occurring nucleoside analog first isolated from species within the Cordyceps genus. Today, it is most commonly produced from cultivated Cordyceps militaris through optimized fermentation and purification technologies, enabling the manufacture of high-purity materials suitable for scientific research and industrial applications. Because of its distinctive chemical structure, Cordycepin has attracted extensive attention in biochemical, pharmacological, and food science research. Researchers have investigated its physicochemical characteristics, biological interactions, and potential applications in areas such as nutraceutical development, functional food ingredients, cosmetic formulations, and laboratory studies. While research is active and expanding, the practical use of Cordycepin should always be evaluated within the relevant regulatory framework and intended application. Commercially, Cordycepin is available in multiple purity grades. High-purity 98% Cordycepin is generally selected for research institutions, formulation development, analytical laboratories, and manufacturers requiring standardized quality and batch-to-batch consistency. Quality assessment typically includes HPLC purity, identity testing, residual solvent analysis, heavy metals, microbiological limits, and other specifications depending on the intended use. As global demand for standardized botanical ingredients continues to grow, understanding how Cordycepin is produced, characterized, and evaluated has become increasingly important for researchers, product developers, and procurement professionals. Key Takeaways Cordycepin is a naturally occurring nucleoside analog known chemically as 3'-Deoxyadenosine. It is primarily associated with Cordyceps militaris and is commonly obtained through controlled cultivation and purification processes. High-purity (98%) Cordycepin is widely used in scientific research and formulation development where standardized quality is essential. Quality evaluation typically includes HPLC purity, identity confirmation, residual solvents, heavy metals, and microbiological testing. Production technology has evolved from simple extraction toward optimized fermentation and downstream purification. Different application sectors require different quality specifications and documentation. Reliable suppliers should provide comprehensive technical documents such as COA, specifications, chromatograms, and safety data sheets. Understanding stability and storage conditions is important for maintaining product quality. Scientific literature on Cordycepin continues to expand across multiple research disciplines. Selecting a qualified manufacturer can help improve consistency, traceability, and technical support. Table of Contents What Is Cordycepin? Why Has Cordycepin Received Increasing Scientific Attention? Chemical Structure and Physicochemical Properties Natural Sources of Cordycepin How Is High-Purity Cordycepin Produced? Quality Standards and Analytical Methods Applications in Research and Industry How to Evaluate Cordycepin Quality Buying Guide for Global Manufacturers Frequently Asked Questions Scientific References 1. What Is Cordycepin? Cordycepin is a naturally occurring nucleoside analog chemically identified as 3'-Deoxyadenosine. Structurally, it is closely related to adenosine, differing by the absence of the hydroxyl group at the 3' position of the ribose sugar. This subtle structural variation has made Cordycepin an important subject of investigation across multiple scientific disciplines, including natural product chemistry, molecular biology, biotechnology, and food science. Originally identified from fungi belonging to the Cordyceps genus, Cordycepin is now primarily associated with Cordyceps militaris, a cultivated medicinal mushroom widely recognized as a commercially sustainable source of this compound. Advances in cultivation techniques and fermentation technologies have significantly improved production efficiency, enabling the availability of high-purity Cordycepin for research and industrial use. Unlike crude mushroom powders or standard mushroom extracts, purified Cordycepin represents a single, chemically characterized compound. This distinction is particularly important for analytical laboratories, formulation scientists, and manufacturers who require precise control over ingredient identity, purity, and batch consistency. Today, high-purity Cordycepin is supplied to universities, research institutes, dietary supplement developers, cosmetic manufacturers, and biotechnology companies worldwide. As interest in standardized botanical ingredients continues to grow, Cordycepin has become one of the most recognized marker compounds derived from Cordyceps militaris. Definition Cordycepin (3'-Deoxyadenosine) is a naturally occurring nucleoside analog isolated primarily from Cordyceps militaris. Commercial high-purity Cordycepin is produced through controlled cultivation, fermentation, extraction, and purification processes and is widely used as a standardized research material and industrial botanical ingredient. CQHERB Technical Insight One common misunderstanding in the market is treating Cordyceps militaris extract and 98% Cordycepin as interchangeable products. In reality, they serve different purposes and are manufactured to different quality specifications. A Cordyceps militaris extract is a complex botanical preparation containing multiple naturally occurring constituents, with Cordycepin representing only one of many compounds. By contrast, 98% Cordycepin is a highly purified single compound that undergoes additional separation and purification steps to achieve a standardized purity level. For applications requiring precise formulation, analytical testing, or reproducible research conditions, high-purity Cordycepin is generally preferred because it offers greater consistency and more clearly defined quality attributes than a conventional mushroom extract. Industry Insight In recent years, global interest in standardized mushroom-derived ingredients has shifted from broad-spectrum extracts toward well-characterized marker compounds with defined specifications. This trend reflects the increasing demand from research institutions and manufacturers for ingredients that provide consistent analytical data, traceable production processes, and comprehensive quality documentation. As production technologies continue to improve, high-purity botanical monomers such as Cordycepin are expected to play an increasingly important role in product development, quality control, and scientific research. Summary   Cordycepin is more than a naturally occurring constituent of Cordyceps militaris—it is a well-characterized botanical compound with defined chemical identity, standardized quality requirements, and growing importance in research and industrial development. Understanding its origin, structure, and production forms the foundation for evaluating its quality and appropriate applications.

Bakuchiol (CAS 10309-37-2) Ultimate Guide (2026) Part 3: Benefits, Scientific Research, Applications, Formulation Guide & Supplier Selection 6. Benefits of Bakuchiol for Skin Bakuchiol has attracted global attention because it delivers a broad range of cosmetic benefits while maintaining excellent skin tolerance. Unlike traditional retinoids, which often cause irritation in sensitive users, Bakuchiol is widely regarded as a gentler yet highly effective botanical active ingredient. Below are its most important scientifically supported cosmetic benefits. 6.1 Anti-Aging Support One of the primary reasons Bakuchiol is widely used in cosmetic formulations is its ability to help reduce visible signs of skin aging. With age, skin naturally loses collagen, elasticity, and firmness. This process leads to the formation of fine lines, wrinkles, and uneven texture. Bakuchiol is believed to support skin renewal pathways associated with collagen maintenance and extracellular matrix integrity. Regular use in skincare formulations has been associated with: Reduction in the appearance of fine lines Improved skin firmness Enhanced elasticity Smoother skin texture This makes Bakuchiol highly valuable in anti-aging serums and creams. 6.2 Helps Improve Skin Tone Appearance Bakuchiol is often used in formulations targeting uneven skin tone and dullness. Its antioxidant properties help reduce oxidative stress, which is one of the key contributors to uneven complexion and premature aging. Cosmetic users often report: Brighter-looking skin More even skin tone Improved overall radiance 6.3 Antioxidant Protection Environmental stressors such as UV radiation, pollution, and lifestyle factors generate free radicals in the skin. These unstable molecules accelerate visible aging. Bakuchiol exhibits antioxidant activity that helps neutralize free radicals, supporting the skin's natural defense system. This antioxidant function is particularly important in: Urban skincare formulations Day creams and serums Anti-pollution cosmetic products 6.4 Suitable for Sensitive Skin Formulations Unlike retinol, which may cause dryness, peeling, or irritation in some users, Bakuchiol is generally well tolerated by a wide range of skin types, including sensitive skin. This makes it especially attractive for: Sensitive skin products Pregnancy-safe skincare concepts (subject to formulation review) Daily-use anti-aging products 6.5 Supports Skin Barrier Function A healthy skin barrier is essential for hydration retention and protection against external irritants. Bakuchiol is frequently used in formulations designed to: Strengthen skin barrier function Improve moisture retention Reduce transepidermal water loss (TEWL) Global Market Trends for Bakuchiol The demand for Bakuchiol has increased steadily over the past decade, driven by the rapid growth of premium skincare, clean beauty, and plant-derived cosmetic ingredients. Several factors continue to support market expansion: Growing consumer preference for botanical alternatives to traditional cosmetic actives. Increased interest in vegan and naturally sourced skincare ingredients. Rising awareness of skin barrier health and sensitive skin care. Continuous innovation in multifunctional cosmetic formulations. Strong demand from premium skincare brands worldwide.   As more cosmetic companies invest in science-based botanical ingredients, Bakuchiol is expected to remain an important component of next-generation anti-aging formulations. 7. Scientific Research Overview Scientific interest in Bakuchiol has increased significantly over the past decade. Multiple in vitro and clinical studies have investigated its cosmetic and dermatological potential. 7.1 Clinical Observations Several comparative studies have evaluated Bakuchiol against retinol in cosmetic applications. While their chemical structures differ, both ingredients have demonstrated similar effects in improving visible signs of skin aging. Key observations include: Improvement in wrinkle appearance Enhanced skin elasticity Better skin smoothness Lower incidence of irritation compared to retinol 7.2 In Vitro Studies Laboratory studies suggest that Bakuchiol may influence several cellular pathways related to: Collagen production Cell renewal Oxidative stress response Inflammatory signaling modulation These mechanisms help explain its broad cosmetic functionality. 7.3 Cosmetic Safety Profile One of Bakuchiol's strongest advantages is its favorable safety profile in cosmetic applications. Unlike some synthetic retinoids, Bakuchiol is generally associated with: Low irritation potential Good skin compatibility Suitable for long-term use formulations However, as with any active ingredient, formulation design and concentration are important factors in final product safety and performance. 8. Cosmetic Applications of Bakuchiol Bakuchiol is a highly versatile cosmetic ingredient that can be used across multiple product categories. 8.1 Facial Care Products Bakuchiol is widely used in: Anti-aging serums Facial creams Eye creams Overnight repair treatments Its ability to support skin renewal makes it especially suitable for premium facial care products. 8.2 Clean Beauty Formulations Due to increasing consumer demand for natural and plant-derived ingredients, Bakuchiol is frequently included in: Vegan skincare products Clean beauty formulations Natural cosmetic lines 8.3 Sensitive Skin Products Because of its good tolerability, Bakuchiol is often selected for: Gentle anti-aging creams Fragrance-free skincare products Dermatology-focused formulations 8.4 Oil-Based Skincare Systems Bakuchiol is oil-soluble, making it ideal for: Facial oils Oil serums Emulsion-based formulations It integrates well with plant oils such as: Jojoba oil Squalane Argan oil 9. Formulation Guide for Cosmetic Developers For cosmetic formulators, understanding how to properly use Bakuchiol is essential to ensure product stability and performance. 9.1 Recommended Usage Level In most cosmetic formulations, Bakuchiol is typically used at: 0.5% – 2.0% (depending on product type and performance requirements) Higher concentrations may be used in specialized formulations under technical guidance. 9.2 Stability Considerations Bakuchiol is relatively stable compared to some retinoids, but it is still sensitive to: Strong light exposure Excessive heat Oxidative environments Recommended formulation practices include: Use of antioxidant systems (e.g., Vitamin E) Air-tight packaging Opaque or UV-protective containers 9.3 Compatibility with Other Ingredients Bakuchiol shows good compatibility with a wide range of cosmetic actives, including: Niacinamide Hyaluronic acid Peptides Ceramides Plant oils Botanical extracts This makes it highly suitable for multifunctional skincare formulations. 9.4 Formulation Types Bakuchiol can be incorporated into: Oil-based serums Emulsions (O/W, W/O systems) Creams and lotions Anhydrous formulations Expert Insights From our experience working with cosmetic manufacturers and formulation teams, successful Bakuchiol products depend on more than ingredient purity alone. Professional formulators typically evaluate: Batch-to-batch consistency Oxidation stability Documentation quality Compatibility with other active ingredients Reliable long-term supply   Selecting a qualified supplier with comprehensive technical support can significantly reduce formulation risks and improve product consistency throughout commercial production. Buyer Tips: What to Look for When Purchasing Bakuchiol Purchasing managers should evaluate Bakuchiol suppliers using multiple quality indicators rather than focusing solely on price. Important evaluation criteria include: Verified HPLC purity Stable production capacity Complete technical documentation Regulatory support Batch consistency Professional technical communication Sample availability Flexible packaging options A reliable supplier can help streamline product development while reducing long-term quality risks.   10. How to Choose a Reliable Bakuchiol Supplier For cosmetic brands and distributors, supplier selection is a critical factor that directly impacts product quality and market success. 10.1 Key Quality Criteria When evaluating Bakuchiol suppliers, consider the following: Purity consistency (HPLC verified) Batch-to-batch stability Impurity profile control Documentation support (COA, TDS, MSDS) Production capability Supply chain stability 10.2 Documentation Requirements A reliable supplier should provide: Certificate of Analysis (COA) Technical Data Sheet (TDS) Safety Data Sheet (SDS/MSDS) HPLC chromatograms (if required) 10.3 Why Consistency Matters In cosmetic formulation, even small variations in raw material quality can significantly affect: Product stability Texture Color Active performance Therefore, consistent quality supply is more important than price alone. 11. Why Choose CQHERB Nanjing Spring & Autumn Biological Engineering Co., Ltd. (CQHERB) is a professional supplier of botanical extracts and cosmetic active ingredients. We focus on providing stable, high-quality ingredients for global cosmetic manufacturers and distributors. Our advantages include: Strict quality control systems Stable batch-to-batch consistency Comprehensive technical documentation (COA, TDS, MSDS) Flexible packaging solutions Export experience for global markets Technical support for formulation development We are committed to supporting cosmetic brands in developing high-performance, safe, and market-ready skincare products.   12.Why We Published This Guide At CQHERB, we regularly communicate with cosmetic manufacturers, formulation laboratories, distributors, and purchasing professionals from around the world. Many customers ask similar questions regarding Bakuchiol's properties, applications, formulation compatibility, and quality evaluation. To help answer these questions in one comprehensive resource, we created this guide based on publicly available scientific literature, industry knowledge, and our experience supplying botanical active ingredients to the global cosmetics market.   Our objective is to provide practical information that supports informed product development and responsible sourcing decisions.   13.Frequently Asked Questions Can Bakuchiol be combined with Niacinamide? Yes. Bakuchiol is commonly formulated with niacinamide to create multifunctional skincare products targeting skin tone, texture, and overall appearance. Can Bakuchiol be used in facial oils? Yes. Because Bakuchiol is oil-soluble, it is particularly suitable for facial oils, oil-based serums, and anhydrous skincare formulations. Is Bakuchiol suitable for sensitive skin? Bakuchiol is generally considered well tolerated and is widely used in formulations intended for sensitive skin. Product performance depends on the overall formulation and individual skin response. How should Bakuchiol be stored? Bakuchiol should be stored in a cool, dry environment away from direct sunlight and excessive heat to help maintain product stability. What technical documents are commonly available? Professional suppliers typically provide documentation such as a Certificate of Analysis (COA), Technical Data Sheet (TDS), and Safety Data Sheet (SDS/MSDS), with additional analytical information available when required.   Looking for a Reliable Bakuchiol Supplier? Choosing a high-quality Bakuchiol supplier is essential for developing stable, effective, and competitive skincare products. At CQHERB (Nanjing Spring & Autumn Biological Engineering Co., Ltd.), we provide cosmetic-grade Bakuchiol with consistent quality, comprehensive technical documentation, and responsive technical support for cosmetic manufacturers, distributors, and research organizations worldwide. Available support includes: Cosmetic-grade Bakuchiol Certificate of Analysis (COA) Technical Data Sheet (TDS) Safety Data Sheet (SDS/MSDS) Sample support for evaluation Flexible packaging options Global export experience   If you are developing new skincare products or sourcing Bakuchiol for commercial production, our team is ready to discuss your technical and sourcing requirements.  

Bakuchiol Ultimate Guide (2026) Part 2: Botanical Source, Extraction Process, Physicochemical Properties & Mechanism of Action Botanical Source of Bakuchiol Where Does Bakuchiol Come From? Bakuchiol is a naturally occurring meroterpene phenol primarily isolated from the seeds and leaves of Psoralea corylifolia L., a medicinal plant belonging to the Fabaceae family. Commonly known as Babchi, this botanical species has been used for centuries in traditional herbal medicine across China, India, and other parts of Asia. Historically, Psoralea corylifolia has been valued for supporting skin health and has appeared in numerous traditional herbal formulations. Modern phytochemical research later identified Bakuchiol as one of its major bioactive constituents, attracting significant interest from cosmetic scientists due to its favorable balance of efficacy and skin compatibility. Today, Bakuchiol is regarded as one of the most important botanical active ingredients used in premium anti-aging skincare products. Botanical Information Item Description Botanical Name Psoralea corylifolia L. Common Name Babchi Plant Family Fabaceae Plant Part Used Seeds (primary), Leaves Major Active Compound Bakuchiol Traditional Applications Herbal medicine and skin care Main Cultivation Regions China, India, Southeast Asia Why Is Psoralea corylifolia an Ideal Source? Compared with many botanical extracts that contain only trace amounts of active compounds, Psoralea corylifolia naturally contains a relatively high concentration of Bakuchiol. This makes it one of the most commercially viable plant sources for industrial production. Several factors contribute to the quality of Bakuchiol raw materials: Geographic origin of the plant Harvest season and maturity Drying and storage conditions Extraction technology Purification process Quality control during manufacturing For cosmetic manufacturers, the consistency of the botanical raw material is just as important as the final purity of Bakuchiol. Stable sourcing helps ensure batch-to-batch reproducibility, which is essential for large-scale formulation and product performance. How Is Bakuchiol Produced? From Botanical Material to Cosmetic Active Ingredient Commercial Bakuchiol production involves several carefully controlled steps designed to preserve the natural active compound while removing impurities. Although manufacturing processes may vary among producers, the overall workflow generally includes: Step 1 – Raw Material Selection High-quality Psoralea corylifolia seeds are selected based on botanical identification, moisture content, and quality standards. Step 2 – Extraction The dried botanical material is processed using appropriate extraction techniques to obtain the crude extract containing Bakuchiol and other naturally occurring constituents. Step 3 – Purification The crude extract undergoes multiple purification stages, such as solvent partitioning and chromatographic separation, to enrich the Bakuchiol content and reduce unwanted impurities. Step 4 – Refinement Further purification helps achieve the desired cosmetic-grade purity while maintaining product stability. Step 5 – Quality Verification Each production batch is typically evaluated using validated analytical methods, such as High-Performance Liquid Chromatography (HPLC), to verify identity, purity, and consistency. Typical Quality Control Parameters Reliable manufacturers generally evaluate several quality attributes before releasing Bakuchiol for commercial use. Parameter Typical Evaluation Appearance Visual inspection Identity HPLC Purity HPLC assay Residual Solvents According to applicable standards Heavy Metals ICP or equivalent methods Microbiological Quality Cosmetic quality requirements Storage Stability Long-term stability evaluation For cosmetic brands, comprehensive technical documentation—including a Certificate of Analysis (COA), Technical Data Sheet (TDS), and Safety Data Sheet (SDS/MSDS)—is valuable for formulation development and regulatory compliance. Physical and Chemical Properties Understanding the physicochemical characteristics of Bakuchiol is essential for successful formulation development. These properties influence ingredient compatibility, stability, processing conditions, and final product performance. Property Specification INCI Name Bakuchiol CAS Number 10309-37-2 Molecular Formula C18H24O Molecular Weight 256.38 g/mol Chemical Class Meroterpene Phenol Appearance Pale yellow to amber viscous liquid Odor Characteristic Solubility Soluble in oils, ethanol, and many cosmetic solvents Water Solubility Practically insoluble Storage Conditions Cool, dry, protected from light Shelf Life Typically 24 months under recommended conditions Formulation Characteristics Bakuchiol is compatible with a wide range of cosmetic ingredients, allowing formulators to develop multifunctional skincare products. It is commonly combined with: Niacinamide Ceramides Hyaluronic Acid Peptides Squalane Tocopherol (Vitamin E) Plant Oils Botanical Extracts This versatility enables the development of advanced formulations targeting multiple skin concerns simultaneously. How Does Bakuchiol Work? Mechanism of Action Although Bakuchiol is structurally different from retinoids, numerous studies suggest that it can influence several biological pathways involved in skin rejuvenation. Rather than acting as a vitamin A derivative, Bakuchiol appears to modulate cellular signaling associated with extracellular matrix maintenance, collagen synthesis, antioxidant defense, and skin barrier support. Current research indicates that Bakuchiol may contribute to healthier-looking skin through several complementary mechanisms. 1. Supports Collagen Production Collagen is one of the most important structural proteins responsible for maintaining skin firmness and elasticity. Natural collagen production gradually declines with age, contributing to wrinkles and skin laxity. Research suggests that Bakuchiol may promote the expression of genes involved in collagen synthesis, helping improve the appearance of aging skin. 2. Helps Reduce Oxidative Stress Daily exposure to ultraviolet radiation, environmental pollution, and other external stressors generates reactive oxygen species (ROS), which accelerate visible skin aging. Bakuchiol exhibits antioxidant activity that helps neutralize free radicals, supporting healthier skin and protecting cellular structures from oxidative damage. 3. Supports Skin Barrier Function A healthy skin barrier is essential for maintaining hydration and reducing sensitivity. Bakuchiol has been reported to help support barrier integrity, making it particularly attractive for formulations designed for dry or sensitive skin. 4. Improves Visible Skin Texture Regular use of Bakuchiol-containing skincare products has been associated with improvements in: Skin smoothness Skin firmness Elasticity Overall skin radiance Appearance of fine lines and wrinkles These benefits have contributed to its widespread adoption in anti-aging formulations. 5. Soothes the Skin Unlike many conventional retinoids, Bakuchiol is generally well tolerated. Its favorable skin compatibility makes it suitable for formulations intended for sensitive skin, helping cosmetic brands expand their product offerings to a broader consumer base. Expert Insight One of the key reasons behind Bakuchiol's rapid adoption is not that it is simply a "natural retinol." Instead, it offers formulators greater flexibility by combining anti-aging efficacy with improved tolerability. This allows brands to create products that appeal to consumers seeking high-performance skincare without the irritation commonly associated with traditional retinoids. For product developers, ingredient quality is equally important. Consistent purity, validated analytical testing, and stable manufacturing processes all contribute to predictable formulation performance and long-term product reliability. CQHERB Technical Note   At Nanjing Spring & Autumn Biological Engineering Co., Ltd. (CQHERB), Bakuchiol is supplied with strict batch quality control and comprehensive technical documentation to support cosmetic product development. Depending on customer requirements, we can provide COA, TDS, SDS/MSDS, chromatographic data, and customized packaging solutions. Our focus is on delivering reliable botanical active ingredients that help customers accelerate formulation development while maintaining consistent product quality.