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20-Deoxyingenol (CAS:54706-99-9) - High-Purity Autophagy Modulator for Research
20-Deoxyingenol is a natural diterpenoid with the molecular formula C₂₀H₂₈O₄ and a molecular weight of 332.43 g/mol. Sourced from the root extracts of Euphorbia species (e.g., Euphorbia kansui or Euphorbia lathyris), it appears as a white to off-white crystalline powder and exhibits hygroscopic properties. With a certified purity of ≥98%, it is suitable for research applications in neuroscience and pharmacology.
Studies indicate its potential in attenuating neurotoxicity and oxidative stress, particularly in models of morphine-induced cognitive impairment.
Product Name :
20-DeoxyingenolCAS No. :
54706-99-9Appearance :
White to off-white crystalline powderSpecification :
98%Source: Euphorbia kansui or Euphorbia lathyris Root Extract
Molecular Formula: C₂₀H₂₈O₄
Molecular Weight: 332.43 g/mol
Appearance: White to off-white crystalline powder (hygroscopic)
20-Deoxyingenol is a potent modulator of cellular clearance pathways with demonstrated therapeutic potential:
Autophagy Activation:
Promotes nuclear translocation of Transcription Factor EB (TFEB), triggering autophagy and lysosomal biogenesis.
Enhances cellular waste clearance mechanisms critical for disease pathology studies.
Therapeutic Research Applications:
Osteoarthritis: Mitigates cartilage degradation by activating TFEB-mediated autophagy.
Oncology: Exhibits anticancer activity through apoptosis induction and cell cycle disruption.
Virology: Shows broad-spectrum antiviral effects in preclinical models.
| Parameter | Specification |
|---|---|
| Purity | ≥98% (HPLC-validated) |
| Identification | NMR, Mass Spectrometry |
| Packaging | 1mg–1kg (glass vials; bulk custom options) |
| Stability | 2 years at -20°C (desiccated) |
| Safety | Research use only; not for human consumption |
Quality Assurance:
Batch-specific Certificates of Analysis (CoA) provided
Compliant with USP/EP pharmacopeia standards
Triple-validated (HPLC-DAD/ELSD, NMR, MS)
Flexible Options:
Small-scale R&D: 5mg, 10mg, 20mg, 50mg, 100mg
Bulk/Bench-scale: 500mg, 1g, 10g, 50g,100g
Global Shipping:
❄️ Cold-chain validated transport: Gel packs (-20°C stability) or dry ice (ultra-low temp)
Sealed foam insulation with tamper-proof packaging
Express delivery (DHL/FedEx) with real-time tracking
Supply Chain Reliability:
ISO-certified manufacturing facilities
Batch-to-batch consistency guaranteed
Technical Expertise:
Custom purification & synthesis services (mg to kg scale)
Application support for autophagy, oncology, and virology studies
Regulatory Compliance:
Full traceability from raw materials to finished products
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