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4',5,7-TRIMETHOXYFLAVONE /Apigenin Trimethyl Ether 98% | CAS 5631-70-9 | Natural Flavonoid Supplier
Apigenin Trimethyl Ether (CAS: 5631-70-9) is a naturally derived methoxyflavone with ≥98% purity, validated by HPLC. Known for its anti-inflammatory, antioxidant, and neuroprotective properties, it is widely applied in nutraceuticals, functional foods, and cosmeceuticals.
Purity: ≥98% (HPLC verified)
Appearance: Yellow to off-white crystalline powder
Functions: NF-κB & COX-2 inhibition, ROS reduction, neuroprotection, anti-aging support
Applications: Nutritional supplements, fortified beverages, anti-aging skincare formulations
Packaging: 100 g / 1 kg / 5 kg with long-term stability under -20°C
Nanjing Spring & Autumn Biological Engineering Co., Ltd. is a trusted manufacturer and global supplier of high-quality flavonoid ingredients. We provide stable supply, competitive pricing, and technical support for research and industrial applications.
Product Name :
4',5,7-TRIMETHOXYFLAVONE /Apigenin Trimethyl EtherCAS No. :
5631-70-9Appearance :
Yellow to off-white crystalline powderSpecification :
98%CAS: 5631-70-9
Molecular Formula: C₁₈H₁₆O₅
Molecular Weight: 312.32 g/mol
Appearance: Yellow crystalline to off-white powder
Multi-Pathway Anti-Inflammatory & Antioxidant Agent
≥98% Purity (HPLC-UV validated, λmax 332 nm)
Anti-Inflammatory Modulator: Suppresses NF-κB signaling and downregulates COX-2 expression.
Antioxidant Protector: Inhibits ROS generation and enhances cellular redox defense.
Cytoprotective Role: Shields neurons and endothelial cells from oxidative stress-induced apoptosis.
Cytokine Regulation: Reduces TNF-α (↓72%) and IL-1β (↓65%) in activated macrophages.
Enzyme Inhibition: Inhibits COX-2 (IC₅₀: 18 μM) and iNOS expression (↓55%).
ROS Suppression: Decreases intracellular ROS by 68% at 20 μM.
Enzyme Induction: Activates Nrf2/HO-1 pathway, enhancing antioxidant enzyme activity (2.6× vs. control).
Neuroprotection: Prevents Aβ-induced neurotoxicity (cell viability ↑45%).
Vascular Health: Improves endothelial nitric oxide production (↑38%) and reduces lipid peroxidation.
Apoptosis Induction: Upregulates Bax/Bcl-2 ratio in cancer cell lines.
Cell Cycle Arrest: Inhibits proliferation via G2/M checkpoint modulation.
*For research purposes only, not for therapeutic claims.
| Parameter | Detail |
|---|---|
| Purity | ≥98% (HPLC-DAD, C18 reverse phase) |
| Source | Plant-derived flavonoid |
| Melting Point | 187–189°C |
| Solubility | DMSO (80 mg/mL), ethanol (25 mg/mL); lipophilic |
| Storage | -20°C in amber container (36-month stability) |
| Key Impurities | ≤1.0% O-methylated flavones (HPLC controlled) |
| Certifications | ISO 9001 |
Anti-Inflammatory Complexes: 50–200 mg/day combined with quercetin or luteolin for synergistic effects.
Cognitive Support Supplements: 10–30 mg/serving in nootropic blends.
Fortified Beverages: Nanoemulsion delivery improves solubility and bioavailability (↑2.7×).
Healthy Oils: Stabilizes lipid systems with antioxidant properties.
Skin Anti-Aging Serums: 0.05–0.2% concentration reduces oxidative stress and glycation markers.
UV Protection Formulas: Acts as a natural photo-protective agent in topical creams.
High Purity: ≥98% verified by HPLC, residual solvents <10 ppm.
Stability: 24–36 months under recommended storage.
Versatility: Applicable across nutraceuticals, functional foods, and cosmeceuticals.
| Quantity | Packaging Method | Shelf Life |
|---|---|---|
| 100 g | Double aluminized bags + argon | 24 months |
| 1 kg | Pharma-grade PET jars | 24 months |
| 5 kg | Vacuum-sealed stainless steel | 24 months |
Stored at -20°C, O₂ <0.1%; stability verified under ICH Q1A guidelines.
Q: How to confirm anti-inflammatory activity?
A: Batch-specific COX-2 and NF-κB inhibition assay data available on request.
Q: Solubility solutions for formulation?
A: Phospholipid complexes and MCT oil carriers enhance bioavailability.
Q: Can it be used in skincare formulations?
A: Yes, validated stability in emulsions and serums at 0.05–0.2% concentration.
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