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Glabridin: Nature’s Gold Standard for Multi-Action Skin Brightening & Antioxidant Defense
Derived from sustainably harvested Glycyrrhiza Glabra roots, Glabridin is a rare, naturally potent compound celebrated as "skin whitening gold" for its unparalleled ability to inhibit tyrosinase activity, disrupt melanin pathways, and visibly reduce hyperpigmentation
Product Name :
GlabridinCAS No. :
59870-68-7Appearance :
Off-white to pale yellow crystalline powderSpecification :
1%-98%CAS: 59870-68-7
Molecular Formula: C₂₀H₂₀O₄
Molecular Weight: 324.37
Appearance: Off-white to pale yellow crystalline powder
Multi-Functional Skin Brightening & Anti-Aging Powerhouse
≥98% Pure: Cosmetic/Pharmaceutical Grade (HPLC-verified)
0.1%-5% Blends: Optimized for brightening serums, sun care, and age-reversal formulations
Tyrosinase Dual-Inhibitor: Unique mechanism blocking both monophenolase and diphenolase activity for superior melanin suppression
Hyperpigmentation Correction:
Reduces melanin synthesis by 56% at 0.4% concentration (vs. 22% for kojic acid), fading sun spots and melasma in 8 weeks with 91% user satisfaction (n=45).
Anti-Photoaging & UV Defense:
Blocks 95% of UVA-induced ROS at 2.0% concentration and boosts collagen IV synthesis by 40% to prevent solar elastosis.
Barrier Enhancement & Anti-Inflammation:
Increases ceramide synthesis by 35% and reduces TNF-α by 78%, calming sensitive skin and improving hydration retention.
Antioxidant Supercharger:
Exhibits 8× stronger free radical scavenging than vitamin E (ORAC: 28,000 μmol TE/g), neutralizing pollution and blue light damage.
| Parameter | Detail |
|---|---|
| Purity Range | 1%, 5%, 10%, 20%, 98%+ (HPLC-DAD) |
| Source | Glycyrrhiza glabra roots (Xinjiang, China - GACP certified) |
| Extraction Method | Ethanol/water → Macroporous resin → Prep-HPLC |
| Melting Point | 156–158°C |
| Solubility | Ethanol, PG, DMI; insoluble in water |
| Storage | -20°C in amber vials (36-month stability) |
| Key Impurities | Licochalcone A ≤0.2% (HPLC-controlled) |
| Certifications | ISO 22716, Halal, COSMOS-approved |
✨ Brightening & Even-Tone Serums:
Synergizes with niacinamide and tranexamic acid at 0.2–2.0% for 4× faster pigment fading than arbutin.
☀️ High-Performance Sun Care:
Critical in SPF 50+ formulations (1–4%) to prevent post-inflammatory hyperpigmentation and repair UV DNA damage.
?♀️ Anti-Aging & Firming Creams:
Combined with retinol and peptides, reduces wrinkle depth by 42% in 12 weeks via MMP-1 inhibition and elastin stimulation.
? Sensitive Skin Solutions:
At 0.5%, calms rosacea redness by 65% and strengthens barrier function in CBD-infused moisturizers.
⚡️ Bioactivity-Preserving Extraction:
CO₂ Supercritical Extraction: Yields 92% glabridin vs. 50% ethanol methods, preserving heat-sensitive flavonoids.
3-Stage Chromatography: HPD-600 resin → Sephadex LH-20 → Prep-HPLC for >98% purity.
? Enhanced Delivery Systems:
Phytosome® Technology: 5.8× skin penetration boost vs. free glabridin (QTY: 4.3 μg/cm²).
? Global Compliance:
China IECIC, EU Cosmetic Regulation 1223/2009, FDA OTC Monograph. Full cosmetic safety dossier available.
| Cargo Weight | Packaging Method | Shipping | Lead Time |
|---|---|---|---|
| 1–10 kg | Vacuum-sealed amber glass vials | Dry Ice FedEx | 5 days |
| 10–100 kg | Pharma-grade aluminum cans | Air freight | 7–12 days |
| >100 kg | Nitrogen-flushed palletized drums | Sea freight | 30–55 days |
How to verify glabridin potency?
Free 10g samples with dual-method COA (HPLC at λmax 282 nm + UPLC-MS/MS confirmation).
Compatible with vitamin C?
Yes—stabilizes L-ascorbic acid in serums (pH 3.5–4.5), enhancing brightening synergy by 120%.
Stability in anhydrous formulas?
Maintains >95% potency for 24 months in oil-based serums; protect from oxygen and light.
? Sustainable & Traceable Sourcing:
Wild-simulated G. glabra from Xinjiang deserts (zero irrigation, 0 pesticide residues).
? Formulation-Ready Solutions:
Custom derivatives:
Glabridin Palmitate: Oil-soluble for makeup products (log P 8.2 vs. native 3.7)
Glabridin-Hyaluronate Complex: Targeted delivery for melasma treatment
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