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High-Purity Costunolide (CAS 553-21-9) | 98% HPLC Grade | Smooth Muscle Research Standard

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High-Purity Costunolide (CAS 553-21-9) | 98% HPLC Grade | Smooth Muscle Research Standard

High-Purity Costunolide (CAS 553-21-9) | 98% HPLC Grade | Smooth Muscle Research Standard

Costunolide is a high-purity sesquiterpene lactone derived from traditional medicinal herbs. This compound is a white crystalline powder extensively utilized in pharmacological research, quality control, and biochemical assays. Its validated biological activities make it ideal for studies on gastrointestinal and smooth muscle functions 

  • Product Name :

    Costunolide
  • CAS No. :

    553-21-9
  • Appearance :

    White crystalline powder
  • Specification :

    98%

🌿 Costunolide (Saussurea Lactone) 98%

CAS: 553-21-9
Molecular Formula: C₁₅H₂₀O₂
Molecular Weight: 232.32
Appearance: White crystalline powder


🔥 Core Value Proposition

Dual-Action Anti-Inflammatory & Cancer Chemopreventive Agent

  • ≥98% Purity: Pharmaceutical grade (HPLC-verified, dual COA with NMR/MS)

  • Multi-Target Bioactivity: Inhibits NF-κB/AP-1 pathways and induces ROS-mediated apoptosis

  • Thermostable & Lipid-Soluble: Ideal for oral formulations and topical delivery systems


✅ Clinically Validated Benefits

  1. Anti-Cancer Efficacy:

    • Suppresses NF-κB p65 subunit in ER⁻ breast cancer (MDA-MB-231) at 20–40 μM, reducing tumor viability by 78% without toxicity to normal mammary cells (MCF-10A).

    • Induces mitochondrial permeability transition in HL-60 leukemia cells, triggering cytochrome c release and apoptosis.

  2. Anti-Inflammatory & Antipyretic Effects:

    • Oral dose of 0.15 mg/kg abolishes LPS-induced fever and reduces carrageenan-induced paw edema by 62% in murine models.

    • Inhibits IL-1β expression by 75% in RAW 264.7 macrophages via blockade of JNK/p38 MAPK pathways.

  3. Osteoprotective & Metabolic Regulation:

    • Dose-dependently inhibits RANKL-induced osteoclast differentiation by suppressing c-Fos/NFATc1 signaling, preventing bone resorption.

    • Exhibits hypoglycemic and hypolipidemic activity in diabetic models.


⚙️ Technical Specifications

Parameter Detail
Purity Range ≥98% (HPLC-DAD, λmax 225 nm) 
Source Aucklandia lappa roots 
Melting Point 106–107°C 
Solubility Chloroform, DMSO, ethanol; insoluble in water
Storage 2–8°C in amber vials (24-month stability) 
Key Impurities Dehydrocostuslactone ≤0.5% (HPLC-controlled) 
   


💊 Pharmaceutical & Nutraceutical Applications

  • Oncology Adjuvants:
    Synergizes with paclitaxel at 10–25 μM to enhance apoptosis in solid tumors.

  • Anti-Arthritis Formulations:
    At 5 mg/kg/day oral dose, reduces joint inflammation and osteoclast activation in RA models.

  • GI Disorder Therapeutics:
    Dual modulation of gastrointestinal motility—spasmolytic at low doses (0.1 mg/kg), prokinetic at higher doses (1 mg/kg).

  • Metabolic Health Supplements:
    50–100 mg doses improve insulin sensitivity and reduce fasting glucose by 18%.


🚀 Competitive Advantages

  • Green Extraction Technology:
    CO₂ supercritical fluid extraction yields 92% purity in initial phase, reducing solvent residues by 40% vs. ethanol methods.

  • Enhanced Bioavailability:
    Liposome encapsulation increases oral absorption 3.8× (AUC: 29.7 μg·h/mL vs. 7.8 μg·h/mL free form).

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📦 Packaging & Delivery

Cargo Weight Packaging Method Shipping Lead Time
1–100 mg Vacuum-sealed glass vials Dry Ice FedEx 5 days
100 mg–1 kg Pharma-grade aluminum cans Air freight 7–12 days
>1 kg Nitrogen-flushed drums Sea freight 30–55 days

❓ FAQ

  • How to validate NF-κB inhibition?
    Free in vitro assay report (p65/p52 subunit Western blot) included with every batch.

  • Compatibility with hydrophilic carriers?
    Use β-cyclodextrin complexation for water-soluble injectables (solubility ↑8× to 16 mg/mL).

  • Stability in topical creams?
    Maintains >95% potency for 18 months in anhydrous bases (pH 5.0–7.0); avoid UV exposure.


🌿 Why Partner With Us?

  • Ethical Sourcing:
    Aucklandia lappa cultivated via regenerative agroforestry in Xinjiang (zero pesticides, blockchain traceability) 410.

  • Custom Derivatives:
    Costunolide Palmitate: Oil-soluble for transdermal patches
    Glycosylated Costunolide: Enhanced bioavailability for nutraceuticals 

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