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Maslinic Acid (Natural Triterpenoid) ≥98% is a high-purity plant-derived compound extracted from olive pomace (Olea europaea), hawthorn, and other medicinal plants. Renowned for its exceptional bioactivity and safety profile, this triterpenoid offers versatile applications in skincare, pharmaceuticals, and nutraceuticals.
Product Name :
Maslinic AcidCAS No. :
4373-41-5Appearance :
Off-white to pale yellow crystalline powderSpecification :
90%-98%CAS: 4373-41-5
Molecular Formula: C₃₀H₄₈O₄
Molecular Weight: 472.70 g/mol
Appearance: Off-white to pale yellow crystalline powder
Dual-Action Anticancer & Antiviral Agent
≥98% Purity (HPLC-ELSD validated)
Anticancer Activity: Inhibits tumor proliferation via NF-κB pathway suppression (blocks IκB-α phosphorylation).
Anti-HIV Agent: Reduces viral spread by 80% through serine protease inhibition.
Multitarget Bioactivity: Antidiabetic, antioxidant, and anti-inflammatory properties.
Oncological Applications
Tumor Suppression: Inhibits DNA-binding of NF-κB p65, inducing apoptosis in cancer cells.
Antimetastatic: Reduces MMP-9 expression by 76% at 10 μM (prevents metastasis).
Antiviral & Metabolic Health
Anti-HIV: Blocks viral release from infected cells (validated by University of Granada).
Antidiabetic: Lowers blood glucose via GLUT4 translocation enhancement.
Antioxidant Efficacy
ROS Scavenging: Neutralizes superoxide and hydroxyl radicals (EC₅₀ < 10 μM).
DNA Protection: Reduces oxidative damage in UV-exposed cells.
| Parameter | Detail |
|---|---|
| Purity | ≥98% (HPLC-ELSD, C18 column) |
| Source | Olea europaea leaves (organic, EU origin) |
| Melting Point | 267–269°C |
| Solubility | Ethanol (50 mg/mL), DMSO (100 mg/mL); insoluble in water |
| Storage | 2–8°C in opaque containers (24-month stability) |
| Key Impurities | Oleanolic acid ≤1.0% (HPLC-controlled) |
Pharmaceutical Development
Anticancer Formulations: 10–50 μM in nanoemulsions for targeted tumor therapy.
HIV Adjuvants: Synergistic with antiretroviral drugs (clinical trial phase).
Nutraceuticals & Cosmeceuticals
Antioxidant Serums: 1–2% in creams for UV protection.
Glucose-Control Capsules: 200 mg doses with berberine (synergy index 1.5).
Green Extraction Tech
Ethanol-Based Extraction: Yields 94.2% purity with 50% solvent reduction vs. conventional methods.
Polymorph Stability
Microcrystalline Form: Bulk density 0.52 g/cm³, optimal for encapsulation 9.
Global Compliance
Dossiers for FDA/EMA drug registration and COSMOS Organic certification.
| Quantity | Packaging Method | Shelf Life |
|---|---|---|
| 10 g | Pharma-grade glass vial + desiccant | 24 months |
| 50 g | Double aluminum foil bag | 24 months |
| 100 g | HDPE jar + nitrogen seal | 24 months |
| 500 g | Vacuum-sealed steel can | 24 months* |
| 1 kg | UN-certified composite drum | 24 months* |
| *Storage at 2–8°C, RH <40% (ICH Q1A validated) . |
Q: How to validate anti-HIV activity?
A: Batch-specific serine protease inhibition assays included (IC₅₀ ≤ 10 μM) .
Q: Solubility for in vivo studies?
A: Use PEG-40 hydrogenated castor oil (solubility ↑ to 80 mg/mL).
Q: Photostability in formulations?
A: Maintains >90% potency with 0.1% ascorbyl palmitate.
Toxicity: LD₅₀ (oral, rat) >2000 mg/kg; non-mutagenic (Ames test) .
Certifications: Vegan, non-GMO, heavy metals (As <0.1 ppm, Pb <0.2 ppm) per ISO 17294.
Regulatory: Ready for FDA OTC Monograph and EU Annex V inclusion .
Shipping: Global dispatch via DHL/FedEx (3–7 days) or air freight (5–10 days).
Support: Batch-specific COA, NMR/HPLC-MS data, and regulatory dossiers provided.
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