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Betulinic Acid (CAS 472-15-1) is a naturally occurring pentacyclic triterpenoid compound, primarily extracted from birch bark (Betula spp.) and other plant sources. With the molecular formula C₃₀H₄₈O₃ and a molecular weight of 456.71, it appears as a white to off-white crystalline powder. This bioactive compound is renowned for its broad-spectrum pharmacological properties.
Product Name :
Betulinic AcidCAS No. :
472-15-1Appearance :
Fine White PowderSpecification :
98%CAS No.: 472-15-1
Molecular Formula: C₃₀H₄₈O₃
Molecular Weight: 456.7
| Parameter | Detail |
|---|---|
| Purity Range | ≥98% (HPLC) |
| Identification | HPLC-DAD, ¹H/¹³C-NMR |
| Solubility | Soluble in DMSO, chloroform; insoluble in water (0.0002 g/L at 25°C) |
| Melting Point | 256-258°C |
| Optical Rotation | +8° (c=1, CHCl₃) |
| Storage | 2-8°C (vacuum-sealed, amber glass; avoid light) |
| Shelf Life | 24 months |
| Industry | Use Cases |
|---|---|
| Pharmaceuticals | - Targeted melanoma therapeutics - Adjuvant for chemo-radiotherapy sensitization |
| Cosmeceuticals | - Anti-acne serums - Collagen-boosting anti-aging creams |
| Nutraceuticals | - Liver detox supplements - Metabolic syndrome support |
| Veterinary | - Canine melanoma topical formulations - Livestock antiviral feed additives |
Selective Cytotoxicity: Kills cancer cells 20x more effectively than normal cells.
Dual Sourcing: Sustainable extraction from Betula alba bark (FSC-certified) or Syzygium claviflorum leaves.
Bioenhanced Forms: β-cyclodextrin complexes available (water solubility ↑ 300x).
Bulk: 1 kg/vacuum aluminum cans with oxygen scavenger.
Samples: 100 mg, 500 mg in argon-purged glass vials.
Storage: Stable 2 years at 2-8°C; avoid freeze-thaw cycles (>5 cycles degrade purity by 0.8%).
Mechanism-Backed Efficacy:
Triggers mitochondrial pore formation (VDAC activation).
Supply Chain Transparency:
Traceable from European birch forests (Batch-specific GPS coordinates).
Formulation Support:
Preclinical data packages for IND applications.
Regulatory Readiness:
DMF Type II filed (US FDA); REACH/ISO 9001certified.
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