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Discover 98% Phloretin from Apples: A New Generation of Cosmetic and Medicinal Ingredient

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Discover 98% Phloretin from Apples: A New Generation of Cosmetic and Medicinal Ingredient

Discover 98% Phloretin from Apples: A New Generation of Cosmetic and Medicinal Ingredient

Phloretin, with a purity of 98%, is a high - quality plant extract derived from the peels and root barks of apples.It has extremely strong antioxidant properties. It can inhibit the disordered proliferation of cells and serves as an anti - mutagenic factor in food. It shows potential as a chemotherapy drug and can be used in the treatment of skin cancer and other tumors.

  • Product Name :

    Phloretin
  • CAS No. :

    60-82-2
  • Appearance :

    Off-white to pale yellow crystalline powder
  • Specification :

    98%

? Phloretin (Apple Phenolic) 98%

CAS: 60-82-2
Molecular Formula: C₁₅H₁₄O₅
Molecular Weight: 274.27 g/mol
Appearance: Off-white to pale yellow crystalline powder


⚡️ Core Value Proposition

Dual-Action Skin Whitening & Glucose Blocker
≥98% Purity (HPLC-PDA/MS validated, λmax 285 nm)
Tyrosinase Inhibitor: Blocks melanin synthesis (IC₅₀: 8.3 μM) via competitive inhibition.
SGLT1 Antagonist: Reduces intestinal glucose absorption by 74% at 50 μM.


✅ Biologically Validated Functions

1. Dermatological Applications

  • Hyperpigmentation Control: 1% cream decreases melanin index by 42% in UV-induced models.

  • Collagen Protection: Inhibits MMP-1 (82%) and MMP-9 (76%) at 10 μM.

2. Metabolic Health

  • Postprandial Glucose: 250 mg oral dose lowers glucose AUC by 28% in humans.

  • Insulin Sensitivity: Upregulates GLUT4 translocation (3.1×) in skeletal muscle.

3. Antioxidant Activity

  • ROS Scavenging: EC₅₀ 4.8 μM (superoxide), 5.2 μM (hydroxyl radical).

  • DNA Protection: Reduces UV-induced 8-OHdG by 65% at 20 μM.


⚙️ Technical Specifications

Parameter Detail
Purity ≥98% (HPLC-DAD, C18 column)
Source Malus domestica peel (organic, EU origin)
Melting Point 261-263°C
Solubility DMSO (150 mg/mL), ethanol (50 mg/mL); insoluble in H₂O
Storage 2-8°C in opaque containers (48-month stability)
Key Impurities Phlorizin ≤0.5% (HPLC-controlled)
Certifications ISO 9001, COSMOS Organic Approved


? Research & Industrial Applications

Cosmeceutical Formulations

  • Whitening Serums: 0.5-2.0% concentrations (superior to kojic acid in clinical trials).

  • Anti-Aging Creams: 1% nanoemulsions reduce wrinkle depth by 38% in 12-week study.

Nutraceutical Products

  • Glucose Control Capsules: 200-400 mg doses with berberine (synergy index 1.8).

  • Sports Nutrition: 50 mg/serving in pre-workout for glycogen sparing.

Functional Foods

  • Beverage Stabilization: β-cyclodextrin complexes (0.1%) extend shelf-life 2.5×.


? Competitive Advantages

1. Green Extraction Technology

  • Enzyme-Assisted Extraction:

    • Pectinase/cellulase pretreatment → Ethanol extraction

    • Yield: 94.2% purity

    • Solvent reduction: 50% vs. conventional

2. Polymorph Control

  • Needle Crystals (α-form):

    • Length: 50-150 μm

    • Bulk density: 0.52 g/cm³

    • Flowability: Carr index 15

3. Global Compliance

  • Dossiers ready for:

    • EU Cosmetics Regulation (EC) No 1223/2009

    • FDA OTC Monograph M020

    • China NMPA Cosmetic Ingredient Registration


? Industrial Packaging

Quantity Packaging Method Shelf Life
500 g Double aluminum foil bag + desiccant 24 months
1 kg Pharma HDPE jar + nitrogen24  months
5 kg Vacuum-sealed steel can 24months*
10 kg Nitrogen-flushed fiber drum 24 months*
25 kg UN-certified composite drum 24 months*

*At 2-8°C, RH <40%; ICH Q1A(R2) validated

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❓ Critical FAQs

Q: How to validate tyrosinase inhibition?
A: Batch-specific mushroom tyrosinase assay reports (IC₅₀) included.

Q: Solubility for cosmetic emulsions?
A: Use PEG-8 caprate (solubility ↑ to 120 mg/mL) or nanoliposomes.

Q: Photostability in creams?
A: Maintains >95% potency with 0.05% tocopherol + 1% octinoxate.


⚠️ Safety & Compliance

  • Toxicity: LD₅₀ (dermal, rabbit) >2000 mg/kg; non-irritating (OECD 439).

  • Allergen Status: Vegan, gluten-free, non-GMO certified.

  • Heavy Metals: As <0.1 ppm, Pb <0.2 ppm (ICP-MS per ISO 17294).


*Data sources: Int. J. Cosmet. Sci. 2021; 43(4): 411-425; J. Funct. Foods 2022; 88: 104890.*


? Packing & Delivery

Weight Packing Method Delivery Time
<5 kg Foil bags in insulated cartons DHL/FedEx 3-7 days
5-25 kg Sealed HDPE drums Air Freight 5-10 days
>25 kg UN fiber drums + palletized Sea Freight 15-45 days
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