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Premium Asiaticoside | CAS 16830-15-2 | Anti-Aging & Wound Healing

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Premium Asiaticoside | CAS 16830-15-2 | Anti-Aging & Wound Healing

Premium Asiaticoside | CAS 16830-15-2 | Anti-Aging & Wound Healing

Asiaticoside (CAS:16830-15-2) is a high-purity triterpenoid glycoside sourced from Centella asiatica, clinically validated to accelerate skin regeneration and combat signs of aging. With ≥98% HPLC purity (ISO 9001 compliant), this bioactive compound targets multiple dermatological pathways.

  • Product Name :

    Asiaticoside
  • CAS No. :

    16830-15-2
  • Appearance :

    Off-white crystalline powder
  • Specification :

    80%-98%

🌿 Asiaticoside 98% (CAS: 16830-15-2)
Source: Centella asiatica Extract
Molecular Formula: C₄₈H₇₈O₁₉
Molecular Weight: 959.14 g/mol
Appearance: White to off-white crystalline powder (hygroscopic)
Key Cosmetic Action: Potent Collagen Booster & Wound Healing Accelerator


⚡️ Dermatological Value Proposition

≥98% Purity (HPLC-validated, λmax 205 nm)

Collagen Synthesis:

  • Stimulates Type I/III collagen production (↑230% at 0.1% vs. control)

  • Activates TGF-β/Smad pathway

Wound Repair & Barrier Strengthening:

  • Upregulates fibronectin & integrin expression (2.8× faster wound closure)

  • Enhances epidermal remodeling (↑45% ceramide synthesis)

Antioxidant & Anti-Inflammatory:

  • Scavenges ROS (IC₅₀: 11.4 μM)

  • Inhibits COX-2/PGE₂ pathway (↓79% IL-1β at 50 μM)


✅ Clinically Validated Skin Benefits

Anti-Aging & Firmness

  • Wrinkle Reduction: 0.5% cream ↓ wrinkle volume by 34% in 12 weeks (n=45)

  • Elasticity Improvement: ↑ skin firmness by 29% (cutometer, 8-week study)

Scar & Stretch Mark Management

  • Prevention: 0.2% serum ↓ hypertrophic scar formation by 63% post-surgery

  • Reduction: 1% emulsion fades striae rubra by 41% in Fitzpatrick III-VI skin

Sensitive Skin Recovery

  • Barrier Repair: 0.1% formulation ↑ TEWL recovery by 67% vs. baseline

  • Redness Calming: ↓ erythema index by 48% in rosacea-prone skin (n=28)


⚙️ Cosmetic-Grade Specifications

Parameter Detail
Purity ≥98% (HPLC-ELSD)
Solubility Water (<1 mg/mL), Ethanol (50 mg/mL), PG (80 mg/mL)
pH Stability 5.0–7.0 (maintains >90% activity)
Storage 2-8°C in amber glass (36-month stability)
Key Impurities Madecassoside ≤3.0%, Asiatic acid ≤1.5%
Certifications ISO 9001

🧪 Formulation Applications

🧴 Serums & Concentrates

  • Anti-Aging Boost: 0.1–0.5% + 0.3% retinol (↓62% irritation)

  • Barrier Serum: 0.2% + 5% niacinamide (↑ Claudin-5 by 2.7×)

💆 Creams & Ointments

  • Scar Care: 1% in silicone gel matrix (↑ collagen alignment)

  • Stretch Mark Cream: 0.5% + 2% hyaluronic acid (↑ elasticity 38%)

🩹 Post-Procedure Care

  • Laser Recovery: 0.3% in aloe gel (↓ healing time by 4.2 days)

  • Peeling Recovery: 0.4% + panthenol (↓ redness 71% vs. placebo)


🚀 Competitive Advantages

Green Extraction: purity >98%, zero solvent residue
Bioavailability: Phospholipid complexation (↑ 4.5× dermal retention vs. free form)
Stability: Protected by 0.1% BHT + nitrogen flushing (94% retention at 25°C/24M)


📦 Packaging & Storage

Quantity Format Shelf Life
50 g Amber glass vial + argon 24 months
250 g Vacuum-sealed aluminum pouch 24 months
1 kg HDPE drum (2-8°C, RH<15%) 24 months

⚠️ Safety & Compliance

  • Dermal Safety: Non-irritating (OECD 439 EpiDerm™, irritation score 0.3)

  • Non-Comedogenic: Comedogenicity index 0 (rabbit ear assay)

  • Heavy Metals: Pb <0.5 ppm, Cd <0.1 ppm (EU 1223/2009 compliant)

  • Allergen Status: Fragrance-free, gluten-free, non-GMO


❓ Frequently Asked Questions

Q: How to solubilize in aqueous systems?
*A: Pre-mix with ethanol/PG (1:3 ratio) → add to water phase at 60°C with stirring.*

Q: Efficacy with enzymatic exfoliants?
A: Synergistic with papain (↑ desmosome degradation 1.8×); use at pH 5.5–6.5.

Q: Optimal pairing for scar reduction?
A: Combine with 0.01% epidermal growth factor (EGF) → ↑ fibroblast migration 3.1×.

Q: Stability in O/W emulsions?
A: Use at pH 5.5–6.8; avoid ascorbic acid → add tocopherol (0.05%) for oxidation control.

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