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Asiaticoside (CAS:16830-15-2) is a high-purity triterpenoid glycoside sourced from Centella asiatica, clinically validated to accelerate skin regeneration and combat signs of aging. With ≥98% HPLC purity (ISO 9001 compliant), this bioactive compound targets multiple dermatological pathways.
Product Name :
AsiaticosideCAS No. :
16830-15-2Appearance :
Off-white crystalline powderSpecification :
80%-98%🌿 Asiaticoside 98% (CAS: 16830-15-2)
Source: Centella asiatica Extract
Molecular Formula: C₄₈H₇₈O₁₉
Molecular Weight: 959.14 g/mol
Appearance: White to off-white crystalline powder (hygroscopic)
Key Cosmetic Action: Potent Collagen Booster & Wound Healing Accelerator
≥98% Purity (HPLC-validated, λmax 205 nm)
Collagen Synthesis:
Stimulates Type I/III collagen production (↑230% at 0.1% vs. control)
Activates TGF-β/Smad pathway
Wound Repair & Barrier Strengthening:
Upregulates fibronectin & integrin expression (2.8× faster wound closure)
Enhances epidermal remodeling (↑45% ceramide synthesis)
Antioxidant & Anti-Inflammatory:
Scavenges ROS (IC₅₀: 11.4 μM)
Inhibits COX-2/PGE₂ pathway (↓79% IL-1β at 50 μM)
Anti-Aging & Firmness
Wrinkle Reduction: 0.5% cream ↓ wrinkle volume by 34% in 12 weeks (n=45)
Elasticity Improvement: ↑ skin firmness by 29% (cutometer, 8-week study)
Scar & Stretch Mark Management
Prevention: 0.2% serum ↓ hypertrophic scar formation by 63% post-surgery
Reduction: 1% emulsion fades striae rubra by 41% in Fitzpatrick III-VI skin
Sensitive Skin Recovery
Barrier Repair: 0.1% formulation ↑ TEWL recovery by 67% vs. baseline
Redness Calming: ↓ erythema index by 48% in rosacea-prone skin (n=28)
Parameter | Detail |
---|---|
Purity | ≥98% (HPLC-ELSD) |
Solubility | Water (<1 mg/mL), Ethanol (50 mg/mL), PG (80 mg/mL) |
pH Stability | 5.0–7.0 (maintains >90% activity) |
Storage | 2-8°C in amber glass (36-month stability) |
Key Impurities | Madecassoside ≤3.0%, Asiatic acid ≤1.5% |
Certifications | ISO 9001 |
🧴 Serums & Concentrates
Anti-Aging Boost: 0.1–0.5% + 0.3% retinol (↓62% irritation)
Barrier Serum: 0.2% + 5% niacinamide (↑ Claudin-5 by 2.7×)
💆 Creams & Ointments
Scar Care: 1% in silicone gel matrix (↑ collagen alignment)
Stretch Mark Cream: 0.5% + 2% hyaluronic acid (↑ elasticity 38%)
🩹 Post-Procedure Care
Laser Recovery: 0.3% in aloe gel (↓ healing time by 4.2 days)
Peeling Recovery: 0.4% + panthenol (↓ redness 71% vs. placebo)
Green Extraction: purity >98%, zero solvent residue
Bioavailability: Phospholipid complexation (↑ 4.5× dermal retention vs. free form)
Stability: Protected by 0.1% BHT + nitrogen flushing (94% retention at 25°C/24M)
Quantity | Format | Shelf Life |
---|---|---|
50 g | Amber glass vial + argon | 24 months |
250 g | Vacuum-sealed aluminum pouch | 24 months |
1 kg | HDPE drum (2-8°C, RH<15%) | 24 months |
Dermal Safety: Non-irritating (OECD 439 EpiDerm™, irritation score 0.3)
Non-Comedogenic: Comedogenicity index 0 (rabbit ear assay)
Heavy Metals: Pb <0.5 ppm, Cd <0.1 ppm (EU 1223/2009 compliant)
Allergen Status: Fragrance-free, gluten-free, non-GMO
Q: How to solubilize in aqueous systems?
*A: Pre-mix with ethanol/PG (1:3 ratio) → add to water phase at 60°C with stirring.*
Q: Efficacy with enzymatic exfoliants?
A: Synergistic with papain (↑ desmosome degradation 1.8×); use at pH 5.5–6.5.
Q: Optimal pairing for scar reduction?
A: Combine with 0.01% epidermal growth factor (EGF) → ↑ fibroblast migration 3.1×.
Q: Stability in O/W emulsions?
A: Use at pH 5.5–6.8; avoid ascorbic acid → add tocopherol (0.05%) for oxidation control.