Glabridin

Glabridin (CAS 59870-68-7) is a prenylated isoflavan purified from the root of Glycyrrhiza glabra (licorice). When sourcing Glabridin 98%, buyers should verify three things before placing an order: batch-specific HPLC chromatograms (not just a COA summary), botanical origin and extraction process documentation, and heavy-metal and residual-solvent data consistent with the destination market's cosmetic or research-use regulations. Reputable suppliers provide 20 g-scale samples with complete documentation before commercial quantities. Key Takeaways · Glabridin is the key purified isoflavan in licorice root; commercial grades range from standardized licorice extracts (10%–40%) to high-purity ≥98% HPLC material. · "98% Glabridin" and "licorice extract standardized to 40% glabridin" are different products with different price structures — confirm which one you are comparing. · Always request: batch COA, HPLC chromatogram, SDS, heavy metals, residual solvents, and botanical source statement. · Glabridin is light- and oxidation-sensitive; packaging and storage conditions directly affect batch-to-batch consistency. · Regulatory status differs by market and application — confirm the intended use (cosmetic ingredient, research compound) with your regulatory team before purchase. 1. Chemical Identity and Specifications Item Specification Product Name Glabridin CAS Number 59870-68-7 Molecular Formula C₂₀H₂₀O₄ Molecular Weight 324.37 g/mol Botanical Source Root of Glycyrrhiza glabra L. Appearance White to off-white crystalline powder Purity ≥98% (HPLC) Solubility Soluble in ethanol, DMSO; poorly soluble in water Documentation COA, HPLC, SDS, TDS available per batch Because Glabridin is a single purified compound rather than a standardized extract, buyers can verify identity and purity analytically with standard laboratory methods, which is one reason it is widely used in cosmetic raw-material and natural-product research programs. 2. Glabridin 98% vs. Standardized Licorice Extract: Know What You Are Comparing A frequent source of confusion in licorice-derived quotations is the difference between purified Glabridin and standardized licorice extract: Parameter Glabridin 98% (purified compound) Licorice extract (standardized, e.g. 40% Glabridin) Composition Single isoflavan compound Complex extract with multiple licorice constituents Purity basis ≥98% Glabridin by HPLC Glabridin content standardized, balance is other extractives Typical use Cosmetic actives, analytical reference, research Finished-product formulations, cost-driven applications Price basis Per-kilogram, purity-driven Lower unit cost, higher inclusion rates Analytical identity Sharp single HPLC peak Multiple-peak fingerprint Before comparing quotations, confirm the basis: "98% Glabridin" and "40% Glabridin licorice extract" are not interchangeable, and neither price nor formulation math can be compared directly. 3. HPLC Verification: What a Valid COA Should Contain When auditing a supplier's Certificate of Analysis for Glabridin 98%, check for the following: 1. Batch-specific data. The COA must reference the exact batch number you will receive. Template COAs without batch numbers are a warning sign. 2. HPLC method and chromatogram. Ask for the actual chromatogram, not only the purity figure. The report should state the column type, detection wavelength, and integration method. 3. Identity confirmation. For high-value shipments, IR or MS confirmation of structure adds assurance that the compound is Glabridin rather than a co-eluting peak. 4. Impurity profile. Residual licorice congeners (e.g., glabrene, liquiritigenin) and process-related impurities should be reported or stated as within specification. 5. Heavy metals and residual solvents. Results should align with the requirements of your destination market — for example, the technical documentation expectations for cosmetic raw materials in the EU or North America. 6. SDS and TDS. Safety data and technical data sheets should be current and consistent with the COA. A practical approach used by many procurement teams: request a 20 g sample with full documentation, run independent HPLC verification at a third-party laboratory, then move to commercial quantities. CQ HERB supports sample evaluation with batch-specific documentation for this purpose. 4. Stability, Packaging and Storage Glabridin is sensitive to light and oxidation. In practice, this affects bulk handling: · Packaging: double-layer PE bags inside fiber drums for 1–25 kg quantities; sealed foil bags for smaller development batches. · Storage: cool, dry, light-protected conditions; keep containers tightly closed. · Shelf life: typically 24 months when stored as recommended; retest dates should appear on the COA. · Formulation note: because solubility in water is low, formulators commonly work with ethanol-based or solubilized systems; discuss the intended formulation format with your supplier so the recommended grade and particle presentation match. 5. Intended Applications and Regulatory Context Glabridin 98% is supplied for: · Cosmetic raw-material development — as a botanical-derived active ingredient used by formulators in skin-care product development, where the finished product's claims must comply with local cosmetic regulations. · Research applications — as a reference compound and research material in phytochemistry and natural-product studies. Regulatory note: the permitted use, labeling, and claim language for Glabridin-containing products differ by market (cosmetic ingredient frameworks, ingredient nomenclature such as INCI, and local advertising rules). Buyers should confirm the intended use and destination-market requirements with their own regulatory team. CQ HERB supplies the ingredient together with technical documentation; the ingredient itself is not a finished product and carries no product claims. 6. Supplier Evaluation Checklist Use this checklist when comparing Glabridin suppliers: · Batch-specific HPLC chromatogram provided (not just a purity number) · Botanical origin and extraction process described transparently · Heavy metals and residual solvents reported · SDS, TDS, and COA consistent with each other · Sample policy: small-quantity samples available for third-party verification · Traceable production information and stable multi-batch supply · Export documentation experience for your destination market · Responsive technical support (not only sales support) Nanjing Spring & Autumn Biological Engineering Co., Ltd. (CQ HERB) supplies Glabridin 98% with batch-based quality documentation including COA, HPLC analytical data, SDS and TDS, and supports sample evaluation before bulk orders. Our quality management system is certified to ISO 9001. 7. Bulk Ordering Practicalities · Sample stage: 20 g with full documentation for independent verification. · Development batches: 1–5 kg, typically ex-stock or short lead time. · Commercial quantities: 25 kg fiber drums; larger volumes scheduled against forecast. · Shipping: export-standard packaging; documentation set provided per shipment. · Lead time: confirm current stock and production schedule when requesting quotation. FAQ Q: What CAS number is Glabridin? A: Glabridin is CAS 59870-68-7, molecular formula C₂₀H₂₀O₄, molecular weight 324.37 g/mol. Q: Is Glabridin the same as licorice extract? A: No. Glabridin is a single purified compound isolated from licorice root. Licorice extract is a complex botanical preparation that may be standardized to a defined Glabridin content. Q: What purity grade should I buy? A: ≥98% HPLC is the common specification for cosmetic raw-material development and research use. Standardized licorice extracts (lower Glabridin content) are a separate product category with a different cost structure. Q: Which documents should a Glabridin supplier provide? A: At minimum: batch COA, HPLC chromatogram, SDS, TDS, botanical source statement, and heavy-metal/residual-solvent data as applicable to your market. Q: Can I get a sample before bulk purchase? A: Yes. CQ HERB provides sample quantities with batch-specific documentation so buyers can complete independent verification before commercial orders. Q: How should Glabridin be stored? A: In cool, dry, light-protected conditions in tightly closed containers. Refer to the SDS and TDS for batch-specific guidance.

What Is Glabridin? Benefits and Applications in Skincare Introduction: Why Glabridin Is Gaining Global Attention In recent years, the global skincare market has shifted strongly toward natural, plant-based, and scientifically backed ingredients. As clean beauty trends continue to dominate North America, Europe, and Asia, formulators are actively seeking effective botanical actives that deliver visible results with strong safety profiles. One such ingredient that has gained significant attention is Glabridin — a powerful flavonoid extracted from licorice root. But what exactly is Glabridin? Why is it considered one of the most valuable skin-brightening and anti-inflammatory compounds in modern cosmetic formulations? Let’s explore. What Is Glabridin? Glabridin is a polyphenolic flavonoid compound isolated from the root of Glycyrrhiza glabra (licorice). It is one of the primary active components responsible for the skin benefits of licorice extract. Unlike crude licorice extract, Glabridin is a purified and standardized active ingredient, offering: Higher stability Stronger biological activity More predictable formulation performance Due to its multifunctional properties, Glabridin is widely used in: Skin brightening products Anti-aging formulations Sensitive skin care Sunscreen and after-sun products Key Benefits of Glabridin in Skincare 1. Skin Brightening and Melanin Inhibition One of Glabridin’s most well-known benefits is its ability to inhibit tyrosinase activity — the key enzyme responsible for melanin production. By regulating melanin synthesis, Glabridin helps: Reduce hyperpigmentation Improve uneven skin tone Brighten dull skin Fade dark spots Compared to many synthetic whitening agents, Glabridin offers a gentler and naturally derived alternative, aligning well with clean beauty positioning. 2. Anti-Inflammatory Properties Glabridin exhibits strong anti-inflammatory activity by suppressing inflammatory mediators in the skin. This makes it particularly valuable in: Acne-care formulations Sensitive skin products Post-treatment recovery creams Redness-reducing serums Its soothing effect enhances both comfort and skin barrier recovery. 3. Antioxidant Protection Oxidative stress is one of the major contributors to skin aging. Glabridin acts as a potent antioxidant that helps neutralize free radicals generated by: UV exposure Environmental pollution Blue light Lifestyle stress By protecting skin cells from oxidative damage, Glabridin supports anti-aging and long-term skin health. 4. UV Support and Photoprotection Research suggests that Glabridin may help reduce UV-induced pigmentation and inflammation. For this reason, it is increasingly used in: Sunscreen formulations After-sun repair products Brightening day creams When combined with UV filters, it enhances overall protective performance. Applications of Glabridin in Cosmetic Formulations Glabridin can be incorporated into various product types, including: Whitening serums Anti-aging creams Facial masks Body lotions Sunscreens Eye creams Typical recommended concentration ranges depend on purity level and formulation goals. Because Glabridin is sensitive to light and oxidation, proper stabilization and formulation expertise are important to maximize its performance. Why High-Purity Glabridin Matters The effectiveness of Glabridin largely depends on: Purity level Extraction method Stability control Heavy metal and solvent residue compliance High-purity Glabridin ensures: Stronger activity Better batch consistency Improved formulation compatibility Compliance with international cosmetic regulations For global brands and contract manufacturers, choosing a reliable raw material supplier is critical. Glabridin Supply from Nanjing Spring & Autumn Biological Engineering Co., Ltd. At Nanjing Spring & Autumn Biological Engineering Co., Ltd., we specialize in high-quality botanical active ingredients for cosmetic applications. Our Glabridin features: High purity options available Strict quality control standards Stable supply capacity Technical documentation support (COA, MSDS, specifications) Export experience for Europe, North America, and Asia markets We focus on providing consistent quality and long-term partnership support for global cosmetic brands and formulators. Market Outlook: The Future of Natural Brightening Agents With increasing regulatory scrutiny on synthetic whitening agents and rising consumer demand for botanical actives, Glabridin is expected to see continuous growth in the global cosmetic raw materials market. Brands are actively reformulating products toward: Clean beauty positioning Naturally derived actives Multifunctional ingredients Glabridin aligns perfectly with these trends. Conclusion Glabridin is more than just a licorice extract derivative — it is a scientifically supported, multifunctional cosmetic active that offers: ✔ Skin brightening✔ Anti-inflammatory benefits✔ Antioxidant protection✔ UV-support properties As demand for natural and high-performance ingredients continues to grow, Glabridin remains a strategic choice for modern skincare formulations.   If you are looking for a reliable Glabridin supplier for your cosmetic formulations, feel free to contact us for technical details or sample requests.