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Author: CQHERB Technical Team
Last Updated: July 2026
Estimated Reading Time: 18 Minutes
Cycloastragenol (CAG) is a naturally occurring cycloartane-type triterpenoid aglycone derived from Astragalus membranaceus. It is most commonly obtained through the controlled hydrolysis or biotransformation of Astragaloside IV, one of the major bioactive saponins found in Astragalus root.
Due to its extremely low natural abundance, commercial-scale Cycloastragenol is rarely produced through direct extraction. Instead, modern manufacturing relies on carefully controlled conversion technologies to achieve high purity and batch consistency.
Today, Cycloastragenol has become one of the most extensively researched compounds from Astragalus species, attracting attention in healthy aging research, nutraceutical development, cosmetic ingredient innovation, and natural product science.
Cycloastragenol is a high-value triterpenoid compound derived from Astragalus species. Commercial products are typically manufactured by converting Astragaloside IV into Cycloastragenol through hydrolysis or biotransformation processes. High-purity Cycloastragenol (≥98% HPLC) is widely used for dietary supplement formulation, cosmetic ingredient development, and scientific research.
| Property | Value |
|---|---|
| Product Name | Cycloastragenol |
| CAS No. | 84605-18-5 |
| Molecular Formula | C30H50O5 |
| Molecular Weight | 490.72 |
| Appearance | White to Off-white Powder |
| Test Method | HPLC |
| Standard Purity | ≥98% HPLC |
Cycloastragenol belongs to the cycloartane triterpenoid family. Unlike Astragaloside IV, it does not contain sugar moieties, resulting in different physicochemical characteristics and formulation properties.
Cycloastragenol naturally occurs in several Astragalus species, including:
Although naturally present, its concentration in the plant is extremely low. Direct extraction is therefore not considered commercially practical for large-scale production.
Most high-purity Cycloastragenol available on the global market is produced through controlled conversion from Astragaloside IV.
Commercial Cycloastragenol production generally involves multiple controlled manufacturing steps to ensure purity and consistency.
Selected Astragalus roots are extracted to obtain crude saponins containing Astragaloside IV.
The extract undergoes multiple purification procedures to isolate high-purity Astragaloside IV.
Astragaloside IV is converted into Cycloastragenol using optimized hydrolysis or biotransformation technologies.
The reaction product is purified through chromatographic separation and crystallization to remove impurities.
Each production batch is analyzed using HPLC and additional quality control methods before packaging.
Astragalus Root
↓
Extraction
↓
Astragaloside IV
↓
Hydrolysis / Biotransformation
↓
Purification
↓
Crystallization
↓
Cycloastragenol
↓
HPLC Quality Control
↓
Packaging
| Feature | Cycloastragenol | Astragaloside IV |
|---|---|---|
| Compound Type | Aglycone | Glycoside |
| Sugar Groups | No | Yes |
| Molecular Weight | Lower | Higher |
| Manufacturing | Conversion Product | Direct Plant Component |
| Market Value | Higher | Lower |
| Purification Difficulty | High | Moderate |
Although closely related, Cycloastragenol and Astragaloside IV are chemically distinct compounds with different production processes and application characteristics.
Over the past decade, Cycloastragenol has become an active topic in natural product and healthy aging research.
Published studies have investigated its potential role in:
It is important to note that much of the available evidence comes from laboratory and preclinical research. Product applications should always comply with local regulatory requirements.
Cycloastragenol is commonly formulated into:
Because of its botanical origin and ongoing scientific interest, Cycloastragenol has also attracted attention for cosmetic ingredient development, including:
Application suitability should be evaluated according to formulation requirements and local cosmetic regulations.
| Item | Specification |
|---|---|
| Botanical Source | Astragalus membranaceus Root |
| Appearance | White Powder |
| Assay | ≥98% HPLC |
| Identification | HPLC |
| Loss on Drying | ≤2.0% |
| Heavy Metals | Complies with Internal Specification |
| Residual Solvents | Controlled According to Applicable Standards |
| Storage | Store in a Cool, Dry Place |
| Shelf Life | 24 Months |
At CQHERB, each production batch undergoes comprehensive quality evaluation to ensure consistency and traceability.
Typical quality control procedures include:
Supporting documentation may include:
When sourcing Cycloastragenol, buyers should consider several important factors:
Selecting a supplier with transparent manufacturing processes and complete quality documentation can help reduce sourcing risks and support long-term product development.
CQHERB specializes in high-purity botanical active ingredients for the global nutraceutical, cosmetic, and pharmaceutical industries.
Our strengths include:
Cycloastragenol naturally occurs in Astragalus species; however, its concentration is extremely low. Most commercial products are manufactured by converting Astragaloside IV through controlled processing.
Research-grade Cycloastragenol is typically supplied at purity levels of 98% HPLC or higher.
Astragaloside IV is a glycoside, while Cycloastragenol is its corresponding aglycone after sugar groups have been removed. They differ in chemical structure, production process, and formulation characteristics.
Cycloastragenol is commonly supplied for nutraceutical development, cosmetic ingredient research, and natural product research.
Professional suppliers typically provide a Certificate of Analysis (COA), Technical Data Sheet (TDS), Safety Data Sheet (SDS/MSDS), HPLC chromatograms, and batch traceability documentation.
Cycloastragenol has become one of the most recognized high-value compounds derived from Astragalus membranaceus. As research into healthy aging, botanical bioactives, and advanced nutraceutical ingredients continues to evolve, demand for high-quality Cycloastragenol is expected to grow across global markets.
For manufacturers and product developers, selecting a supplier with robust manufacturing capabilities, transparent quality control, and complete technical documentation is essential for ensuring product consistency and regulatory compliance.
CQHERB is committed to supplying high-purity Cycloastragenol with strict quality management, comprehensive technical support, and reliable global B2B service.
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