Astragalus Extract

Cycloastragenol Ultimate Guide (2026) Everything You Need to Know About Cycloastragenol (CAG): Benefits, Manufacturing, Specifications, Applications & Buying Guide Author: CQHERB Technical Team Last Updated: July 2026 Estimated Reading Time: 18 Minutes What Is Cycloastragenol? Cycloastragenol (CAG) is a naturally occurring cycloartane-type triterpenoid aglycone derived from Astragalus membranaceus. It is most commonly obtained through the controlled hydrolysis or biotransformation of Astragaloside IV, one of the major bioactive saponins found in Astragalus root. Due to its extremely low natural abundance, commercial-scale Cycloastragenol is rarely produced through direct extraction. Instead, modern manufacturing relies on carefully controlled conversion technologies to achieve high purity and batch consistency. Today, Cycloastragenol has become one of the most extensively researched compounds from Astragalus species, attracting attention in healthy aging research, nutraceutical development, cosmetic ingredient innovation, and natural product science. Quick Answer Cycloastragenol is a high-value triterpenoid compound derived from Astragalus species. Commercial products are typically manufactured by converting Astragaloside IV into Cycloastragenol through hydrolysis or biotransformation processes. High-purity Cycloastragenol (≥98% HPLC) is widely used for dietary supplement formulation, cosmetic ingredient development, and scientific research. Key Takeaways Cycloastragenol is a rare aglycone naturally derived from Astragalus species. Commercial production primarily relies on Astragaloside IV conversion rather than direct extraction. High-purity material (≥98% HPLC) is preferred for research and premium formulations. Manufacturing technology plays a critical role in purity, impurity profile, and production cost. Professional suppliers should provide comprehensive quality documentation, including COA, SDS, TDS, and HPLC chromatograms. Table of Contents What Is Cycloastragenol? Chemical Properties Natural Sources Manufacturing Process Cycloastragenol vs Astragaloside IV Scientific Research Interest Potential Applications CQHERB Product Specifications Quality Control How to Choose a Reliable Supplier Frequently Asked Questions Chemical Properties Property Value Product Name Cycloastragenol CAS No. 84605-18-5 Molecular Formula C30H50O5 Molecular Weight 490.72 Appearance White to Off-white Powder Test Method HPLC Standard Purity ≥98% HPLC Cycloastragenol belongs to the cycloartane triterpenoid family. Unlike Astragaloside IV, it does not contain sugar moieties, resulting in different physicochemical characteristics and formulation properties. Natural Sources of Cycloastragenol Cycloastragenol naturally occurs in several Astragalus species, including: Astragalus membranaceus Astragalus mongholicus Although naturally present, its concentration in the plant is extremely low. Direct extraction is therefore not considered commercially practical for large-scale production. Most high-purity Cycloastragenol available on the global market is produced through controlled conversion from Astragaloside IV. How Is Cycloastragenol Manufactured? Commercial Cycloastragenol production generally involves multiple controlled manufacturing steps to ensure purity and consistency. Step 1. Extraction of Astragalus Root Selected Astragalus roots are extracted to obtain crude saponins containing Astragaloside IV. Step 2. Purification of Astragaloside IV The extract undergoes multiple purification procedures to isolate high-purity Astragaloside IV. Step 3. Hydrolysis or Biotransformation Astragaloside IV is converted into Cycloastragenol using optimized hydrolysis or biotransformation technologies. Step 4. Purification The reaction product is purified through chromatographic separation and crystallization to remove impurities. Step 5. Quality Testing Each production batch is analyzed using HPLC and additional quality control methods before packaging. Typical Manufacturing Flow Astragalus Root ↓ Extraction ↓ Astragaloside IV ↓ Hydrolysis / Biotransformation ↓ Purification ↓ Crystallization ↓ Cycloastragenol ↓ HPLC Quality Control ↓ Packaging Cycloastragenol vs Astragaloside IV Feature Cycloastragenol Astragaloside IV Compound Type Aglycone Glycoside Sugar Groups No Yes Molecular Weight Lower Higher Manufacturing Conversion Product Direct Plant Component Market Value Higher Lower Purification Difficulty High Moderate Although closely related, Cycloastragenol and Astragaloside IV are chemically distinct compounds with different production processes and application characteristics. Why Has Cycloastragenol Attracted Scientific Interest? Over the past decade, Cycloastragenol has become an active topic in natural product and healthy aging research. Published studies have investigated its potential role in: Telomerase-related research Cellular senescence studies Oxidative stress models Immune system research Healthy aging research Skin biology studies Cellular metabolism It is important to note that much of the available evidence comes from laboratory and preclinical research. Product applications should always comply with local regulatory requirements. Potential Applications Dietary Supplements Cycloastragenol is commonly formulated into: Capsules Tablets Powder blends Softgels Functional nutrition products Cosmetic Ingredients Because of its botanical origin and ongoing scientific interest, Cycloastragenol has also attracted attention for cosmetic ingredient development, including: Anti-aging serums Facial creams Premium skincare products Eye care formulations Application suitability should be evaluated according to formulation requirements and local cosmetic regulations. CQHERB Cycloastragenol Specifications Item Specification Botanical Source Astragalus membranaceus Root Appearance White Powder Assay ≥98% HPLC Identification HPLC Loss on Drying ≤2.0% Heavy Metals Complies with Internal Specification Residual Solvents Controlled According to Applicable Standards Storage Store in a Cool, Dry Place Shelf Life 24 Months Quality Control At CQHERB, each production batch undergoes comprehensive quality evaluation to ensure consistency and traceability. Typical quality control procedures include: HPLC Assay Identity Verification Heavy Metal Analysis Residual Solvent Testing Microbiological Testing (where applicable) Stability Evaluation Batch Traceability Supporting documentation may include: Certificate of Analysis (COA) Technical Data Sheet (TDS) Safety Data Sheet (SDS/MSDS) HPLC Chromatogram Production Flow Chart Buyer Checklist: How to Select a Reliable Cycloastragenol Supplier When sourcing Cycloastragenol, buyers should consider several important factors: Is the manufacturing route clearly described? Is the product tested by HPLC? Are chromatograms available? Is batch consistency maintained? Can the supplier provide COA, TDS, and SDS? Does the supplier have experience serving international B2B customers? Is technical support available for formulation and documentation? Selecting a supplier with transparent manufacturing processes and complete quality documentation can help reduce sourcing risks and support long-term product development. Why Choose CQHERB? CQHERB specializes in high-purity botanical active ingredients for the global nutraceutical, cosmetic, and pharmaceutical industries. Our strengths include: Professional botanical extract manufacturing Strict batch quality control HPLC-tested high-purity products Complete export documentation Technical support for international customers Stable production capacity for long-term supply Frequently Asked Questions Is Cycloastragenol naturally extracted? Cycloastragenol naturally occurs in Astragalus species; however, its concentration is extremely low. Most commercial products are manufactured by converting Astragaloside IV through controlled processing. What purity is commonly available? Research-grade Cycloastragenol is typically supplied at purity levels of 98% HPLC or higher. What is the difference between Cycloastragenol and Astragaloside IV? Astragaloside IV is a glycoside, while Cycloastragenol is its corresponding aglycone after sugar groups have been removed. They differ in chemical structure, production process, and formulation characteristics. Which industries use Cycloastragenol? Cycloastragenol is commonly supplied for nutraceutical development, cosmetic ingredient research, and natural product research. What quality documents should a supplier provide? Professional suppliers typically provide a Certificate of Analysis (COA), Technical Data Sheet (TDS), Safety Data Sheet (SDS/MSDS), HPLC chromatograms, and batch traceability documentation. Conclusion Cycloastragenol has become one of the most recognized high-value compounds derived from Astragalus membranaceus. As research into healthy aging, botanical bioactives, and advanced nutraceutical ingredients continues to evolve, demand for high-quality Cycloastragenol is expected to grow across global markets. For manufacturers and product developers, selecting a supplier with robust manufacturing capabilities, transparent quality control, and complete technical documentation is essential for ensuring product consistency and regulatory compliance.   CQHERB is committed to supplying high-purity Cycloastragenol with strict quality management, comprehensive technical support, and reliable global B2B service.

IntroductionAstragalus membranaceus, a traditional medicinal plant widely used in Asia, has attracted increasing global attention for its unique bioactive compounds. Among them, Cycloastragenol is a naturally occurring triterpenoid saponin found in Astragalus roots. With its distinctive molecular structure and high purity availability, Cycloastragenol is gaining recognition in the health food and dietary supplement industry as a premium botanical ingredient. What is Cycloastragenol?Cycloastragenol is a small-molecule compound belonging to the astragaloside family. It is derived through a careful extraction and purification process from Astragalus root, ensuring stability and bioavailability suitable for nutraceutical applications. Unlike crude extracts, purified Cycloastragenol provides consistent quality for use in high-value formulations. Applications in Health Foods and Dietary SupplementsCycloastragenol’s popularity in the health food sector is driven by its compatibility with various product formats, including: Capsules & Tablets – Ideal for single-ingredient supplements or complex herbal formulas targeting general wellness. Functional Beverages – Can be blended into herbal teas, ready-to-drink tonics, and health beverages with minimal impact on taste. Powdered Formulations – Suitable for instant drink powders or nutritional blends, enabling easy daily intake. Combination Formulas – Often paired with other adaptogens, antioxidants, or plant extracts to create synergistic health-support products.       Why Manufacturers Choose Cycloastragenol Natural Origin – Plant-based ingredient derived from Astragalus membranaceus. High Purity & Consistency – Available in standardized purity levels for reliable formulation. Versatile Use – Compatible with multiple dosage forms and manufacturing processes. Market Appeal – Meets growing consumer demand for premium herbal ingredients in functional foods and supplements. Quality & Supply from At Nanjing Spring & Autumn Biological As a professional manufacturer of botanical extracts, Nanjing Spring & Autumn Biological Engineering Co., Ltd. offers high-quality Cycloastragenol with strict control over raw material sourcing, production, and testing. Our products are designed to support the needs of health food brands, supplement manufacturers, and global ingredient distributors.       ConclusionWith its natural origin, purity, and flexibility in application, Cycloastragenol is a standout ingredient for next-generation health food formulations. Partnering with an experienced supplier ensures the quality and reliability essential for success in today’s competitive nutraceutical market.