Cycloastragenol 98%

Cycloastragenol 98% Supplier: Purity, CAS Identity, COA & Bulk Buying Guide Cycloastragenol is a high-value botanical compound of interest to natural product researchers, ingredient developers, and specialty raw material buyers. When sourcing Cycloastragenol 98%, buyers need to look beyond the purity figure on a product listing. Chemical identity, assay methodology, batch documentation, supply consistency, and supplier communication all matter when qualifying a material for further evaluation. This guide explains how to evaluate Cycloastragenol 98%, what to review in a Certificate of Analysis (COA), how to prepare a bulk sourcing inquiry, and which questions to ask before placing an order. Quick Answer: How Do You Choose a Cycloastragenol 98% Supplier? To evaluate a Cycloastragenol 98% supplier, confirm the intended chemical identity and CAS number, request the current product specification and batch-specific COA, review the analytical method used to determine purity, and confirm the available quantity, packaging, storage recommendations, lead time, and shipping terms. A listing that states “98% purity” is only a starting point. Buyers should understand how the assay result was obtained and whether the documentation corresponds to the exact material being offered. For bulk purchasing, request written confirmation of the grade, minimum order quantity, available stock, sample options, and documentation before making a purchasing decision. Key Takeaways Confirm chemical identity: Match the product name, CAS number, molecular formula, and specification to the material required for your project. Review the assay method: A purity percentage should be interpreted together with its analytical method and reporting basis. Request batch-specific documentation: A COA should identify the batch and show the relevant test items, methods, acceptance criteria, and results. Separate purity from overall quality: Purity alone does not establish the complete impurity profile, contaminant status, or suitability for a particular application. Evaluate supply capability: Confirm sample availability, bulk quantities, packaging, lead time, and repeat-order arrangements. Define the intended application: Research, ingredient development, and commercial formulation projects may have different documentation and quality requirements. 1. What Is Cycloastragenol? Cycloastragenol is a triterpenoid sapogenin associated with Astragalus-derived natural products. It is described in chemical databases as an aglycone related to astragaloside IV. The compound is of interest in natural product chemistry and research involving botanical constituents. For ingredient buyers, its value begins with establishing the correct chemical identity and obtaining material that meets a clearly defined specification. Cycloastragenol should not be confused with Astragalus root powder, an Astragalus extract, or an astragaloside-standardized extract. These materials have different compositions and cannot be treated as interchangeable solely because they are associated with the same botanical source. Cycloastragenol: Basic Chemical Information Property Information Product name Cycloastragenol Common abbreviation CAG CAS number commonly listed 78574-94-4 Molecular formula C₃₀H₅₀O₅ Molecular weight Approximately 490.72 g/mol Chemical class Triterpenoid sapogenin Botanical association Astragalus species Commercial grade discussed in this guide 98% Analytical documentation Confirm the current specification and available batch records with the supplier Public chemical references list Cycloastragenol under CAS 78574-94-4, with molecular formula C₃₀H₅₀O₅ and a molecular weight of approximately 490.72 g/mol. Buyers should independently verify the identity required for their project and ensure that the supplier's documentation matches it. Reference: PubChem, Cycloastragenol. https://pubchem.ncbi.nlm.nih.gov/compound/13943286 2. What Does Cycloastragenol 98% Mean? Cycloastragenol 98% generally indicates a material grade with a stated assay or purity target of 98%. However, the meaning of that number depends on the specification and analytical procedure used. Before comparing quotations, buyers should clarify the following: Is 98% the minimum acceptance limit or a representative result? Is the result reported on an as-is basis or a dry basis? Which analytical technique is used? What are the applicable test conditions and calculation method? Does the reported value come from the actual batch being supplied? Are relevant impurities and other quality attributes evaluated separately? A reported assay result should not automatically be interpreted as proof of every aspect of material quality. For example, a purity result does not by itself establish compliance with microbiological limits, residual-solvent requirements, heavy-metal specifications, or the requirements of a particular finished product. 98% Purity Versus a Standardized Astragalus Extract Comparison point Cycloastragenol 98% Standardized Astragalus extract Product type High-purity individual compound Botanical extract with a defined standardization target Composition Intended to be predominantly Cycloastragenol Contains a mixture of botanical constituents Main specification focus Compound identity and assay Botanical identity, extract specifications, and marker content Documentation priorities Identity, assay method, batch results Botanical source, extract details, marker assay, and batch results Purchasing considerations Analytical verification and required quantity Standardization level, source material, extraction details, and intended use These product types serve different procurement purposes. Buyers should select the material based on the actual project specification rather than comparing their prices or percentages as if they represented the same product. 3. How to Verify Cycloastragenol Identity and CAS Information Chemical identity is a basic requirement when sourcing a high-purity compound. A mismatch in product name, CAS number, or specification can create problems during laboratory evaluation, internal quality review, and purchasing approval. Before ordering, check that the following information is consistent across the quotation, product specification, COA, product label, and any supporting analytical records: Product name and relevant synonyms. CAS number required by the buyer. Molecular formula and molecular weight, where applicable. Stated purity grade and assay acceptance criteria. Batch number and document revision details. Analytical method and reporting basis. If a buyer's internal specification or database lists a different CAS number, do not assume that the discrepancy is unimportant. Ask the supplier and the buyer's technical team to resolve the identity requirement before purchase. The same principle applies to product descriptions that use terms such as “natural,” “botanical,” or “high purity.” Such terms do not replace the need for clear identity and quality documentation. 4. How to Evaluate HPLC and Other Analytical Data Analytical data are important when comparing Cycloastragenol suppliers. However, the phrase “HPLC tested” does not fully describe a method or establish that two suppliers' results are directly comparable. What Buyers Should Review 1. Analytical technique Ask which technique was used for the assay and whether the method is appropriate for the compound and the intended measurement. Depending on the analytical characteristics of a substance, the detection system and sample preparation can affect the result. 2. Method details Where available and appropriate, review the method reference, column, mobile phase, detector, sample preparation, and calculation procedure. Do not assume that every supplier uses the same method simply because both report an HPLC result. 3. Chromatographic evidence When chromatograms are available, check whether the report identifies the relevant peak and provides enough information for the intended review. A chromatogram is supporting evidence, not an automatic guarantee of identity or complete impurity characterization. 4. Batch traceability Confirm that the analytical report relates to the batch quoted or supplied. A generic specification sheet and a batch-specific COA serve different purposes. 5. Independent verification For projects requiring stronger supplier qualification, buyers may arrange independent testing using an agreed method and acceptance criteria. Why Assay Methods Matter Results from different analytical methods may not be directly comparable. A sound supplier evaluation therefore considers both the reported number and the procedure used to obtain it. For Cycloastragenol, buyers with demanding analytical requirements should discuss method suitability and the available supporting evidence with the supplier before relying on a percentage figure alone. CQHERB recommends that customers communicate their required assay method or internal specification at the inquiry stage so that the proposed material and available documentation can be evaluated against the project's needs. 5. What Should a Cycloastragenol COA Include? A Certificate of Analysis (COA) records the test results for a particular material or batch against defined specifications. Its usefulness depends on whether it clearly identifies the material and documents the relevant quality checks. When reviewing a Cycloastragenol COA, buyers should look for the following information where applicable: COA item What to check Product name Does it match the ordered material? Batch or lot number Can the tested material be traced to the supplied batch? Test item Are the required quality attributes listed? Specification or acceptance limit Is the criterion clearly stated? Test method Is the method identified where needed? Result Is the reported result clear and interpretable? Test or issue date Is the document current for the batch under review? Authorized release information Is the document appropriately approved by the supplier? The exact content of a COA varies by product specification and supplier quality system. Additional documents may be needed depending on the intended market, application, and buyer qualification procedure. COA, Specification Sheet, and SDS: What Is the Difference? COA: Records analytical results for an identified batch. Product specification or TDS: Describes defined product attributes, acceptance criteria, and technical information. SDS: Provides safety information relevant to handling, storage, exposure control, and emergency response. These documents are complementary rather than interchangeable. Buyers should request the documents relevant to their project and confirm availability before placing an order. 6. How to Choose a Reliable Cycloastragenol Supplier A competitive price is useful, but it should not be the only factor in supplier selection. Buyers need to assess whether the offered material, documentation, and supply arrangements meet their requirements. Supplier Qualification Checklist Product and technical fit Can the supplier confirm the exact product identity and required grade? Is the stated purity supported by an appropriate analytical method? Are the specification and available batch documents clear? Can the supplier explain any limitations in the offered grade? Commercial fit What quantities are available for evaluation and bulk purchasing? Is there a minimum order quantity? Are sample costs and freight quoted separately?   What are the packaging options and estimated lead time? Can the supplier discuss repeat-order availability? Documentation and communication Can the supplier provide the documents actually available for the offered batch? Are product claims consistent with the supporting records? Can the supplier clarify the proposed shipping terms and destination requirements? Is the supplier responsive to technical and purchasing questions? Questions to Ask Before Ordering For a more efficient qualification process, buyers can send a concise list of questions: What Cycloastragenol grade and assay specification are available? Which CAS number is stated in the product documentation? Which method is used for the purity assay? Can you provide the current specification and a representative or batch-specific COA, as appropriate? What sample quantities and bulk quantities can you supply? What are the MOQ, packaging, lead time, and shipping options? Which additional documents are available for the intended application? Clear answers help buyers compare suppliers on a like-for-like basis and reduce misunderstandings before an order is placed. 7. Buying Cycloastragenol in Bulk: What to Confirm Bulk procurement requires more than confirming the price per kilogram. The buyer and supplier should agree on the grade, quantity, batch documentation, delivery arrangements, and acceptance requirements. Small-Quantity Evaluation For initial evaluation, confirm the available sample size, sample price, freight cost, expected dispatch time, and documents that can accompany the sample. If the material will be tested by an external laboratory, agree on the test method and acceptance criteria before testing. This makes the results easier to interpret and compare. Bulk and Repeat Orders For larger purchases, confirm: Required quantity and packaging format. Whether the quoted material is currently in stock or subject to production. Batch availability and expected lead time. Applicable specification and documentation. Shipping terms, destination, and freight arrangements. How future batches will be reviewed against the agreed requirements. For repeat procurement, buyers should establish a written specification and a consistent batch-review process rather than relying only on the wording of an earlier quotation. Information to Include in a Bulk Inquiry To receive a more accurate quotation, provide the supplier with: Product: Cycloastragenol Required grade: for example, 98%, subject to the agreed specification CAS number required by your project Quantity: sample, grams, kilograms, or planned annual demand Intended application and relevant technical requirements Destination country Required documents or analytical method Target delivery date, if applicable The more clearly these requirements are defined, the easier it is for the supplier to determine whether the available material is a suitable match. 8. Cycloastragenol 98% from CQHERB CQHERB supplies botanical raw materials and high-purity compounds for B2B customers involved in ingredient sourcing, research, and formulation development. For buyers evaluating Cycloastragenol 98%, CQHERB can discuss the requested grade, order quantity, available product information, and applicable purchasing arrangements. Before confirming an order, buyers should communicate their required chemical identity, assay specification, quantity, destination, and documentation needs. The proposed material and the available batch records can then be reviewed against those requirements. To inquire about Cycloastragenol 98%, please contact CQHERB: Company: Nanjing Spring & Autumn Biological Engineering Co., Ltd. Email: sale05@cqherb.com Website: https://www.cqherb.com/ Please include your required quantity, destination country, and any specific analytical or documentation requirements in your inquiry. 9. Frequently Asked Questions About Cycloastragenol 98% What is the CAS number of Cycloastragenol? CAS 78574-94-4 is commonly listed for Cycloastragenol in public chemical references. Buyers should confirm that the CAS number in the supplier's documentation matches the exact identity required for their project. What does Cycloastragenol 98% mean? It generally describes a grade with a stated assay or purity target of 98%. Buyers should confirm the acceptance limit, analytical method, reporting basis, and batch result before comparing offers. Is a COA enough to verify Cycloastragenol quality? A COA is an important part of supplier qualification, but it should be reviewed alongside the product specification, analytical method, batch traceability, and any additional quality requirements relevant to the intended application. Should I request HPLC data before purchasing? If analytical verification is important to your project, ask which method is used and what supporting data are available. Review the method and results against your own technical requirements rather than relying on the term “HPLC tested” alone. What is the difference between Cycloastragenol and Astragalus extract? Cycloastragenol is an individual compound, whereas an Astragalus extract contains a mixture of botanical constituents. An extract standardized to a particular marker is not automatically equivalent to a high-purity Cycloastragenol product. Can I buy Cycloastragenol in bulk? Bulk availability, minimum order quantity, packaging, lead time, and pricing depend on the supplier's current offering and the requested grade. Send the required quantity and destination to obtain a quotation based on your needs. Which documents should I request from a supplier? Commonly requested documents include a product specification or TDS, a batch-specific COA when available, and an SDS. Other documents may be needed depending on the buyer's quality system, application, and destination market. How can I request a Cycloastragenol quotation from CQHERB? Email sale05@cqherb.com with your required grade, quantity, destination country, and analytical or documentation requirements. CQHERB can review the inquiry and confirm the relevant product and commercial details. Conclusion Selecting a Cycloastragenol 98% supplier requires a structured review of chemical identity, assay methodology, batch documentation, and commercial supply arrangements. For buyers comparing suppliers, the most useful starting point is a clear specification supported by relevant analytical information. Confirm the requirements before requesting samples or placing a bulk order, and ensure that the offered material matches the intended project. For Cycloastragenol 98% sourcing inquiries, contact CQHERB at sale05@cqherb.com. References PubChem. Cycloastragenol: chemical identity, molecular formula, and molecular weight. https://pubchem.ncbi.nlm.nih.gov/compound/13943286 Sigma-Aldrich. Cycloastragenol, ≥98% (HPLC): product information and listed chemical properties. https://www.sigmaaldrich.com/PA/en/product/sigma/sml1448 Note: Public chemical references provide background information. Product-specific specifications, analytical methods, batch results, and document availability should be confirmed with the supplier before purchase.

Astragalus Extract Cycloastragenol: A Growing Botanical Active for Healthy-Aging and Longevity Research Quick Answer Cycloastragenol is a naturally occurring triterpenoid sapogenin associated with Astragalus species, particularly Astragalus membranaceus. It is closely related to astragaloside compounds and has attracted scientific interest because of its reported effects on telomerase activity and cellular aging-related pathways.  In the United States, Cycloastragenol occupies an interesting position between botanical research, nutraceutical ingredients, healthy-aging products and longevity-focused formulations. The U.S. market already shows commercial and research activity around Cycloastragenol. Major scientific suppliers including Sigma-Aldrich, TCI America, Cayman Chemical and distributors such as VWR list Cycloastragenol for research and natural-product applications. Consumer-facing U.S. products also market Cycloastragenol as a longevity- and telomere-oriented ingredient. For B2B buyers, however, the most important question is not simply whether a supplier offers “Cycloastragenol 98%.” Buyers should evaluate chemical identity, purity, analytical method, botanical source, batch consistency, COA documentation, heavy metals, residual solvents, microbiological specifications and regulatory positioning. For manufacturers and ingredient distributors looking to enter the U.S. healthy-aging market, high-purity Cycloastragenol derived from Astragalus is a specialized botanical ingredient with applications spanning research, nutraceutical development and longevity-oriented product concepts.     Key Takeaways · Cycloastragenol is a triterpenoid sapogenin associated with Astragalus. · It is particularly associated with Astragalus membranaceus research. · Cycloastragenol is structurally related to Astragalus saponins, including astragaloside compounds. · Telomerase activation is one of the most important research areas surrounding Cycloastragenol. · Preclinical studies have investigated Cycloastragenol in cellular aging, oxidative stress, immune-cell function and other biological pathways. · U.S. scientific suppliers already offer Cycloastragenol, including ≥98% HPLC products. · U.S. consumer products also demonstrate commercial interest in Cycloastragenol as a healthy-aging ingredient. · FDA records show that a concentrated Astragalus extract containing >95% Cycloastragenol was the subject of a U.S. New Dietary Ingredient notification in 2010. This does not mean that FDA approved Cycloastragenol as a drug or dietary ingredient; NDI notifications have specific regulatory meanings. · Product identity should be verified carefully because different databases and suppliers may associate Cycloastragenol with different CAS numbers. · For B2B buyers, purity + analytical documentation + batch consistency are more meaningful than a simple “98%” marketing statement.     1. What Is Cycloastragenol? Cycloastragenol is a naturally occurring pentacyclic triterpenoid and sapogenin associated with the roots of Astragalus species. It is particularly relevant to research involving Astragalus membranaceus, a botanical traditionally used in Asian herbal medicine. Chemically, Cycloastragenol is closely associated with Astragalus triterpene saponins. PubChem describes it as an aglycone derivative of astragaloside IV and identifies it as a pentacyclic triterpenoid sapogenin. Typical chemical information includes: Property Cycloastragenol Common Name Cycloastragenol Botanical Source Astragalus species Key Source Astragalus membranaceus Chemical Class Pentacyclic triterpenoid Category Sapogenin Molecular Formula C₃₀H₅₀O₅ Molecular Weight 490.72 g/mol Physical Form Powder Common Research Purity ≥98% HPLC Commercial research suppliers in the U.S. market list Cycloastragenol at ≥98% HPLC, demonstrating that high-purity material is already established within the research-chemical supply chain.     2. Cycloastragenol and Astragalus Extract: What Is the Difference? This distinction is particularly important for B2B buyers. Astragalus Extract is a botanical extract containing multiple naturally occurring constituents. Cycloastragenol is a specific purified triterpenoid constituent associated with Astragalus. Therefore, the terms should not be used interchangeably. Astragalus Extract A standardized Astragalus extract may contain: · Astragalosides · Polysaccharides · Flavonoids · Saponins · Other botanical constituents Cycloastragenol Cycloastragenol represents a more specifically defined chemical constituent. This makes it more appropriate when a formulation or research project requires: · defined chemical identity · high-purity active material · analytical quantification · reproducible experimental conditions · controlled concentration · mechanistic research For this reason, CQHERB can position the product not simply as an ordinary Astragalus root extract, but as a specialized high-purity Astragalus-derived active ingredient.     3. Why Is Cycloastragenol Attracting Attention in the U.S.? The U.S. market shows interest in Cycloastragenol from several different directions. 3.1 Research Chemical Market Cycloastragenol is already available through major U.S.-facing scientific suppliers. For example: · Sigma-Aldrich lists Cycloastragenol ≥98% HPLC. · TCI America lists Cycloastragenol as a research chemical. · Cayman Chemical offers Cycloastragenol for research use. · VWR lists multiple Cycloastragenol products from research suppliers. This creates a clear B2B opportunity for suppliers capable of offering: high purity + consistent batches + analytical documentation + competitive bulk pricing.     4. Cycloastragenol and the U.S. Healthy-Aging Market Beyond laboratory research, Cycloastragenol has become associated with the broader healthy-aging and longevity ingredient category. Current U.S. consumer products illustrate this positioning. For example, ProHealth Longevity markets a Cycloastragenol product at 10 mg per capsule and positions it around telomere and healthy-aging research. Other U.S.-market products emphasize: · telomere support · longevity · cellular health · healthy aging · antioxidant-related positioning · high-purity Cycloastragenol These commercial products demonstrate that Cycloastragenol is not limited to the laboratory-reagent market. Instead, it sits at the intersection of: Botanical Ingredients → Nutraceuticals → Healthy Aging → Longevity Research → Cellular Biology This makes Cycloastragenol particularly interesting for ingredient manufacturers and distributors targeting premium U.S. markets.     5. Cycloastragenol and Telomerase Research One of the most frequently studied characteristics of Cycloastragenol is its relationship with telomerase activity. Scientific research has reported that Cycloastragenol can stimulate telomerase activity in experimental systems. For example, research published in PubMed reported Cycloastragenol-associated telomerase activation in neuronal and cellular models. Another review described Cycloastragenol as a small-molecule telomerase activator and discussed its potential relevance to age-associated conditions, while also noting that further research is needed to clarify efficacy and potential adverse effects. This makes telomerase one of the most important scientific keywords associated with Cycloastragenol. Important distinction Telomerase research does not mean that a Cycloastragenol ingredient has been proven to reverse aging or extend human lifespan. For responsible B2B marketing, CQHERB recommends using language such as: “Cycloastragenol has been investigated for its effects on telomerase activity and cellular aging-related pathways.” rather than: “Cycloastragenol reverses aging.” This distinction is important for scientific credibility and regulatory risk management.     6. Emerging Research Areas Scientific literature has explored Cycloastragenol across multiple biological research areas. 6.1 Telomerase and Telomere Research This is currently one of the most recognizable research directions. Researchers have investigated: · telomerase activity · hTERT expression · telomere biology · cellular replicative capacity · aging-related cellular pathways     6.2 Oxidative Stress Research Research has also investigated the relationship between Cycloastragenol and oxidative stress pathways. A study reported that Cycloastragenol increased NRF2 nuclear localization and activity and affected downstream cytoprotective pathways in experimental models. This provides a scientific basis for investigating Cycloastragenol in: · oxidative stress research · cellular defense pathways · aging biology · NRF2-related research     6.3 Immune Cell Research Earlier research investigated Cycloastragenol-related telomerase activity and cellular function in human CD8+ T lymphocytes. Cayman Chemical's research documentation references work examining telomere loss, proliferative capacity and antiviral functions of CD8+ T cells. This area may be relevant to researchers studying: · immune-cell biology · T-cell function · cellular aging · telomere biology     6.4 Bone and Osteogenic Research Experimental studies have also examined Cycloastragenol in bone-related models. One study reported effects on osteogenic differentiation and mineralization through a telomerase-associated mechanism in cell and zebrafish models. This remains an area of preclinical research, rather than established clinical treatment.     7. U.S. Market Evidence: Is There Real Commercial Interest? Rather than relying on unsupported market-size estimates, several concrete indicators can be observed. Indicator 1: Major U.S. Research Suppliers Cycloastragenol is commercially listed by multiple established scientific suppliers serving the U.S. market. Examples include: · Sigma-Aldrich · TCI America · Cayman Chemical · VWR/Avantor distribution channels Indicator 2: U.S. Consumer Products Cycloastragenol is also sold in U.S.-market supplements positioned around longevity and healthy aging. Indicator 3: Historical U.S. Regulatory Activity FDA's public list of New Dietary Ingredient notifications includes a 2010 notification concerning a concentrated Astragalus membranaceus extract containing more than 95% Cycloastragenol for TA-65®. This is an important historical market signal because it shows that Cycloastragenol-rich Astragalus ingredients have been considered within the U.S. dietary-ingredient regulatory framework. However, an NDI notification should not be described as FDA approval. FDA explains that when an ingredient qualifies as a new dietary ingredient, manufacturers or distributors may have notification obligations and must establish a reasonable expectation of safety under the proposed conditions of use.     8. What Are U.S. Buyers Looking for in Cycloastragenol? For CQHERB, this is perhaps the most important commercial section. Based on the current U.S. supplier landscape, buyers can be divided into several groups. 1. Nutraceutical Ingredient Companies These companies may be looking for: · bulk Cycloastragenol · standardized Astragalus extract · high-purity material · stable supply · documentation · private-label ingredient support 2. Dietary Supplement Manufacturers Potential applications include formulations positioned around: · healthy aging · longevity research · cellular health · telomere research 3. Research Institutions Researchers may require: · ≥98% purity · analytical characterization · COA · HPLC data · MS data · NMR data · SDS · batch traceability 4. Ingredient Distributors Distributors typically prioritize: · competitive pricing · MOQ flexibility · reliable lead time · export documentation · repeatable specifications · private-label or OEM support     9. Why High-Purity Cycloastragenol Matters For a specialized botanical active, purity is only one part of quality. A professional supplier should be able to provide evidence for: Chemical Identity · Correct botanical source · Correct chemical identity · CAS/reference number · Molecular formula · Molecular weight Purity HPLC or another validated analytical method should be used to quantify the target compound. Commercial U.S. suppliers currently list Cycloastragenol products at ≥98% HPLC, establishing this as a recognizable research-grade specification. Batch-to-Batch Consistency For commercial formulation, consistent purity between batches is critical. Contaminant Control Depending on the intended market, buyers may request: · Heavy metals · Residual solvents · Microbial testing · Pesticide residues · Mycotoxins · Other botanical contaminants Documentation A professional B2B package may include: · COA · Specification Sheet · SDS · HPLC chromatogram · MS data · NMR data · Certificate of Origin · Manufacturing information     10. Cycloastragenol CAS Number: An Important Buyer Check This deserves a separate section because it can cause confusion during international sourcing. Different scientific databases and commercial suppliers currently display different CAS associations for Cycloastragenol. For example: · FDA's Substance Registration System identifies Cycloastragenol with UNII X37D9F2L0V and lists 78574-94-4 among its synonyms/mappings. · Sigma-Aldrich lists a Cycloastragenol product under CAS 78574-94-4. · NLM's MeSH database associates Cycloastragenol with 84605-18-5. · Sigma-Aldrich also has a separate product record under 84605-18-5. Therefore, professional buyers should verify CAS, stereochemical identity, InChIKey, analytical data and supplier documentation together, rather than relying on the CAS number alone. For CQHERB's final product page, I recommend using the exact identity appearing on your own: COA + Specification + HPLC + MS/NMR documentation. This will make the product page much more credible to U.S. technical buyers.     11. Cycloastragenol vs Astragaloside IV These two ingredients are often confused because they are both associated with Astragalus. Feature Cycloastragenol Astragaloside IV Category Triterpenoid sapogenin Triterpenoid saponin Botanical association Astragalus Astragalus Molecular Formula C₃₀H₅₀O₅ Different molecular structure Research focus Telomerase, cellular aging, signaling Saponin/pharmacological research Typical positioning High-purity active / longevity research Astragalus saponin research Commercial form Powder / high-purity compound Powder / standardized extract Buyer priority Purity & chemical identity Purity & standardized content Cycloastragenol is particularly attractive when a customer wants a defined active molecule rather than a broad-spectrum Astragalus extract.     12. Potential Applications for Cycloastragenol CQHERB can position Cycloastragenol for several B2B applications. Nutraceutical Research · Healthy-aging formulations · Longevity-oriented products · Cellular health formulations · Botanical active research Research & Development · Telomerase research · Telomere biology · Cellular aging · Oxidative stress · NRF2-related research · Immune-cell research Cosmetic Research Potential research interest may include: · skin aging · cellular protection · skin barrier research · oxidative stress · fibroblast/keratinocyte models These should be described as research and formulation applications, not as established disease-treatment claims.     13. How to Choose a Cycloastragenol Supplier When sourcing Cycloastragenol internationally, buyers should ask at least the following questions: 1. What is the exact chemical identity? Ask for: · CAS · Molecular formula · Molecular weight · Structure · InChIKey if available 2. What is the actual purity? Do not rely only on: “98% Cycloastragenol” Ask: 98% by which analytical method? 3. Can the supplier provide HPLC data? A chromatogram provides substantially more information than a simple specification statement. 4. Is the product botanical-derived or synthetic? This distinction can be commercially important depending on the application. 5. What is the source plant? For botanical material, buyers should confirm: Astragalus membranaceus and the relevant plant part, such as root. 6. Can the supplier provide batch documentation? A professional B2B supplier should be able to provide relevant documentation upon request.     14. Why Work With CQHERB for Cycloastragenol? At CQHERB, our positioning is not simply: “We sell Cycloastragenol.” Our goal is to provide research-oriented botanical ingredients with transparent specifications and professional technical support. For Cycloastragenol buyers, CQHERB can support projects requiring: High-Purity Cycloastragenol Suitable for research, ingredient development and specialized formulation projects. Astragalus-Based Botanical Ingredients For customers who need broader Astragalus extracts rather than isolated Cycloastragenol. Technical Documentation Available documentation can include: · COA · Specification Sheet · SDS · Analytical information · Botanical source information · Batch information Flexible B2B Supply We can support different purchasing requirements, from: Laboratory Samples → Small R&D Orders → Pilot Projects → Commercial Bulk Supply International B2B Support CQHERB is positioned to support overseas buyers with: · Product selection · Technical documentation · Sample evaluation · Packaging · Export support · Bulk quotation     15. CQHERB Technical Insight Why Cycloastragenol Is Different From a Conventional Astragalus Extract A conventional botanical extract contains a complex mixture of compounds. Cycloastragenol provides a more specific chemical target. This distinction can be important for: Research reproducibility and formulation standardization. For research applications, a defined compound allows researchers to better control: · concentration · dose · experimental conditions · analytical measurement · batch comparison For commercial formulations, a defined active may also make it easier to establish a consistent ingredient specification. This is one reason high-purity Cycloastragenol can occupy a different commercial position from a conventional Astragalus root extract.     16. U.S. Market Positioning Strategy for Cycloastragenol For the U.S. market, we recommend positioning Cycloastragenol around four major themes: 01 — Healthy Aging The strongest consumer-facing category. 02 — Telomerase Research The strongest scientific keyword. 03 — Premium Botanical Active The strongest ingredient-industry positioning. 04 — High-Purity B2B Supply The strongest commercial positioning for CQHERB. This creates a clear product story: Astragalus → Cycloastragenol → Telomerase Research → Healthy Aging → Premium Botanical Ingredient → B2B Supply     17. Regulatory Considerations for the U.S. Market This point should be handled carefully on a professional B2B website. FDA distinguishes dietary supplements from drugs. Dietary supplements fall under the food regulatory framework, while products intended to diagnose, cure, mitigate, treat or prevent disease may fall into drug territory. For ingredients that qualify as new dietary ingredients, FDA's NDI framework may require premarket notification and information supporting a reasonable expectation of safety under the proposed conditions of use. Therefore, CQHERB should avoid statements such as: ❌ “Cycloastragenol treats aging.” ❌ “Cycloastragenol cures age-related diseases.” ❌ “Clinically proven to extend human lifespan.” Instead, use: ✅ “Cycloastragenol has been investigated for telomerase activity.” ✅ “Cycloastragenol is a research-active compound associated with Astragalus.” ✅ “Research has explored its potential relevance to cellular aging pathways.” This approach makes the website more suitable for both scientific audiences and international B2B buyers.     18. Frequently Asked Questions What is Cycloastragenol? Cycloastragenol is a naturally occurring triterpenoid sapogenin associated with Astragalus species, particularly Astragalus membranaceus. Is Cycloastragenol the same as Astragalus extract? No. Astragalus extract is a complex botanical preparation, while Cycloastragenol is a specific triterpenoid constituent associated with Astragalus. What is Cycloastragenol used for? Cycloastragenol is studied in areas including telomerase activity, cellular aging, oxidative stress and immune-cell biology. Is Cycloastragenol popular in the U.S.? There is clear commercial and research activity in the U.S. market. Major scientific suppliers and U.S. nutraceutical companies currently offer Cycloastragenol products. What purity should I buy? For research and specialized ingredient applications, ≥98% HPLC is a commonly encountered high-purity specification among commercial research suppliers. Can Cycloastragenol be used in dietary supplements? The regulatory status depends on the exact ingredient, formulation, intended use, labeling and applicable U.S. requirements. Buyers should conduct a product-specific regulatory review rather than assuming that commercial availability equals FDA approval. FDA's NDI framework is relevant where an ingredient qualifies as a new dietary ingredient. Does Cycloastragenol extend human lifespan? Current scientific literature does not establish that Cycloastragenol extends human lifespan. Research has primarily focused on biological mechanisms such as telomerase activity and cellular pathways. What documents should I request from a supplier? At minimum: · COA · Specification Sheet · HPLC · SDS · Botanical source · Batch information · Heavy-metal testing where applicable · Residual-solvent testing where applicable     19. Why Choose CQHERB Cycloastragenol? If you are sourcing Cycloastragenol for nutraceutical development, botanical research, healthy-aging formulations or commercial ingredient applications, CQHERB can provide a professional B2B supply solution. Our focus is: High Purity Consistent Quality Transparent Documentation Reliable Supply Technical Support Global B2B Service Whether you need a laboratory sample, a development batch or commercial-volume supply, our team can work with you to determine the appropriate Cycloastragenol specification for your project.     20. Conclusion Cycloastragenol represents an important specialized ingredient at the intersection of Astragalus botanical science, telomerase research, healthy aging and the growing longevity-oriented ingredient market. The U.S. market already provides several signals of commercial interest: Cycloastragenol is listed by established scientific suppliers, appears in U.S. nutraceutical products and has a history of regulatory interaction through an NDI notification involving a Cycloastragenol-rich Astragalus extract. For B2B buyers, however, the opportunity is closely connected to quality and documentation. A reliable Cycloastragenol supplier should provide more than a purity number. Buyers should evaluate chemical identity, analytical methodology, botanical source, batch consistency and supporting documentation. CQHERB aims to provide Cycloastragenol and Astragalus-derived botanical ingredients for international research, nutraceutical and ingredient-development markets, with a focus on quality, transparency and reliable B2B supply.  

Cycloastragenol Ultimate Guide (2026) Everything You Need to Know About Cycloastragenol (CAG): Benefits, Manufacturing, Specifications, Applications & Buying Guide Author: CQHERB Technical Team Last Updated: July 2026 Estimated Reading Time: 18 Minutes What Is Cycloastragenol? Cycloastragenol (CAG) is a naturally occurring cycloartane-type triterpenoid aglycone derived from Astragalus membranaceus. It is most commonly obtained through the controlled hydrolysis or biotransformation of Astragaloside IV, one of the major bioactive saponins found in Astragalus root. Due to its extremely low natural abundance, commercial-scale Cycloastragenol is rarely produced through direct extraction. Instead, modern manufacturing relies on carefully controlled conversion technologies to achieve high purity and batch consistency. Today, Cycloastragenol has become one of the most extensively researched compounds from Astragalus species, attracting attention in healthy aging research, nutraceutical development, cosmetic ingredient innovation, and natural product science. Quick Answer Cycloastragenol is a high-value triterpenoid compound derived from Astragalus species. Commercial products are typically manufactured by converting Astragaloside IV into Cycloastragenol through hydrolysis or biotransformation processes. High-purity Cycloastragenol (≥98% HPLC) is widely used for dietary supplement formulation, cosmetic ingredient development, and scientific research. Key Takeaways Cycloastragenol is a rare aglycone naturally derived from Astragalus species. Commercial production primarily relies on Astragaloside IV conversion rather than direct extraction. High-purity material (≥98% HPLC) is preferred for research and premium formulations. Manufacturing technology plays a critical role in purity, impurity profile, and production cost. Professional suppliers should provide comprehensive quality documentation, including COA, SDS, TDS, and HPLC chromatograms. Table of Contents What Is Cycloastragenol? Chemical Properties Natural Sources Manufacturing Process Cycloastragenol vs Astragaloside IV Scientific Research Interest Potential Applications CQHERB Product Specifications Quality Control How to Choose a Reliable Supplier Frequently Asked Questions Chemical Properties Property Value Product Name Cycloastragenol CAS No. 84605-18-5 Molecular Formula C30H50O5 Molecular Weight 490.72 Appearance White to Off-white Powder Test Method HPLC Standard Purity ≥98% HPLC Cycloastragenol belongs to the cycloartane triterpenoid family. Unlike Astragaloside IV, it does not contain sugar moieties, resulting in different physicochemical characteristics and formulation properties. Natural Sources of Cycloastragenol Cycloastragenol naturally occurs in several Astragalus species, including: Astragalus membranaceus Astragalus mongholicus Although naturally present, its concentration in the plant is extremely low. Direct extraction is therefore not considered commercially practical for large-scale production. Most high-purity Cycloastragenol available on the global market is produced through controlled conversion from Astragaloside IV. How Is Cycloastragenol Manufactured? Commercial Cycloastragenol production generally involves multiple controlled manufacturing steps to ensure purity and consistency. Step 1. Extraction of Astragalus Root Selected Astragalus roots are extracted to obtain crude saponins containing Astragaloside IV. Step 2. Purification of Astragaloside IV The extract undergoes multiple purification procedures to isolate high-purity Astragaloside IV. Step 3. Hydrolysis or Biotransformation Astragaloside IV is converted into Cycloastragenol using optimized hydrolysis or biotransformation technologies. Step 4. Purification The reaction product is purified through chromatographic separation and crystallization to remove impurities. Step 5. Quality Testing Each production batch is analyzed using HPLC and additional quality control methods before packaging. Typical Manufacturing Flow Astragalus Root ↓ Extraction ↓ Astragaloside IV ↓ Hydrolysis / Biotransformation ↓ Purification ↓ Crystallization ↓ Cycloastragenol ↓ HPLC Quality Control ↓ Packaging Cycloastragenol vs Astragaloside IV Feature Cycloastragenol Astragaloside IV Compound Type Aglycone Glycoside Sugar Groups No Yes Molecular Weight Lower Higher Manufacturing Conversion Product Direct Plant Component Market Value Higher Lower Purification Difficulty High Moderate Although closely related, Cycloastragenol and Astragaloside IV are chemically distinct compounds with different production processes and application characteristics. Why Has Cycloastragenol Attracted Scientific Interest? Over the past decade, Cycloastragenol has become an active topic in natural product and healthy aging research. Published studies have investigated its potential role in: Telomerase-related research Cellular senescence studies Oxidative stress models Immune system research Healthy aging research Skin biology studies Cellular metabolism It is important to note that much of the available evidence comes from laboratory and preclinical research. Product applications should always comply with local regulatory requirements. Potential Applications Dietary Supplements Cycloastragenol is commonly formulated into: Capsules Tablets Powder blends Softgels Functional nutrition products Cosmetic Ingredients Because of its botanical origin and ongoing scientific interest, Cycloastragenol has also attracted attention for cosmetic ingredient development, including: Anti-aging serums Facial creams Premium skincare products Eye care formulations Application suitability should be evaluated according to formulation requirements and local cosmetic regulations. CQHERB Cycloastragenol Specifications Item Specification Botanical Source Astragalus membranaceus Root Appearance White Powder Assay ≥98% HPLC Identification HPLC Loss on Drying ≤2.0% Heavy Metals Complies with Internal Specification Residual Solvents Controlled According to Applicable Standards Storage Store in a Cool, Dry Place Shelf Life 24 Months Quality Control At CQHERB, each production batch undergoes comprehensive quality evaluation to ensure consistency and traceability. Typical quality control procedures include: HPLC Assay Identity Verification Heavy Metal Analysis Residual Solvent Testing Microbiological Testing (where applicable) Stability Evaluation Batch Traceability Supporting documentation may include: Certificate of Analysis (COA) Technical Data Sheet (TDS) Safety Data Sheet (SDS/MSDS) HPLC Chromatogram Production Flow Chart Buyer Checklist: How to Select a Reliable Cycloastragenol Supplier When sourcing Cycloastragenol, buyers should consider several important factors: Is the manufacturing route clearly described? Is the product tested by HPLC? Are chromatograms available? Is batch consistency maintained? Can the supplier provide COA, TDS, and SDS? Does the supplier have experience serving international B2B customers? Is technical support available for formulation and documentation? Selecting a supplier with transparent manufacturing processes and complete quality documentation can help reduce sourcing risks and support long-term product development. Why Choose CQHERB? CQHERB specializes in high-purity botanical active ingredients for the global nutraceutical, cosmetic, and pharmaceutical industries. Our strengths include: Professional botanical extract manufacturing Strict batch quality control HPLC-tested high-purity products Complete export documentation Technical support for international customers Stable production capacity for long-term supply Frequently Asked Questions Is Cycloastragenol naturally extracted? Cycloastragenol naturally occurs in Astragalus species; however, its concentration is extremely low. Most commercial products are manufactured by converting Astragaloside IV through controlled processing. What purity is commonly available? Research-grade Cycloastragenol is typically supplied at purity levels of 98% HPLC or higher. What is the difference between Cycloastragenol and Astragaloside IV? Astragaloside IV is a glycoside, while Cycloastragenol is its corresponding aglycone after sugar groups have been removed. They differ in chemical structure, production process, and formulation characteristics. Which industries use Cycloastragenol? Cycloastragenol is commonly supplied for nutraceutical development, cosmetic ingredient research, and natural product research. What quality documents should a supplier provide? Professional suppliers typically provide a Certificate of Analysis (COA), Technical Data Sheet (TDS), Safety Data Sheet (SDS/MSDS), HPLC chromatograms, and batch traceability documentation. Conclusion Cycloastragenol has become one of the most recognized high-value compounds derived from Astragalus membranaceus. As research into healthy aging, botanical bioactives, and advanced nutraceutical ingredients continues to evolve, demand for high-quality Cycloastragenol is expected to grow across global markets. For manufacturers and product developers, selecting a supplier with robust manufacturing capabilities, transparent quality control, and complete technical documentation is essential for ensuring product consistency and regulatory compliance.   CQHERB is committed to supplying high-purity Cycloastragenol with strict quality management, comprehensive technical support, and reliable global B2B service.